رابطة سطح سرمی کورتیزول و ویتامین C با چاقی

نوع مقاله: مقاله پژوهشی

نویسندگان

1 کارشناس‌ارشد علوم تغذیه. گروه تغذیه، دانشکدة علوم تغذیه و صنایع غذایی، دانشگاه علوم پزشکی شهید بهشتی تهران، ایران.

2 دکترای علوم تغذیه.گروه تغذیه بالینی و رژیم درمانی، دانشکدة علوم تغذیه و صنایع غذایی، دانشگاه علوم پزشکی شهید بهشتی تهران، ایران.

چکیده

زمینه و هدف: افزایش سطح کورتیزول بدنبال استرس، در پرخوری استرسی و نهایتا چاقی، نقش دارد. از سویی دیگر، افراد دارای سطح سرمی بالای ویتامین C، نشانه­های استرس بدنی و ذهنی کمتری نشان می­دهند و سطح کورتیزول پایین­تری دارند. هدف مطالعه حاضر تعیین رابطه بین سطح سرمی کورتیزول و ویتامین C با چاقی است.                                                                                                                                                                                                   
روش بررسی: در این مطالعة مورد- شاهدی، 140 زن سالم (46 زن چاق و 94 زن دارای وزن طبیعی) 17 تا 44 ساله به روش نمونه­گیری متوالی و آسان انتخاب شد. چاقی به صورت Kg/m2 30 ≤ BMI و چاقی شکمی به صورت دور کمر 88  ≥سانتی­متر تعریف شد. سطح سرمی ویتامین C به روش شیمیایی و سطح کورتیزول با روش الایزا اندازه­گیری شد. از آنجایی که افسردگی، اضطراب و نگرش غذایی منجر به افزایش ترشح کورتیزول می­شوند، نقش آنها به­عنوان فاکتورهای مخدوش­کننده در این مطالعه در نظر گرفته شد. داده­ها با استفاده از آزمون t و رگرسیون لجستیک مورد تجزیه و تحلیل قرار گرفت.  
یافته­ها: ارتباط معناداری بین سطح سرمی ویتامینC با BMI مشاهده نشد (07/0=P). بعد از تعدیل اثر عوامل مخدوش­گر، زنانی که در بالاترین سهک سطح سرمی کورتیزول قرار داشتند، احتمال کمتری برای چاقی عمومی (نسبت شانس: 2/0، 05/0=P) و چاقی شکمی (نسبت شانس:2/0، 02/0=P) داشتند.
نتیجه­گیری: در مطالعة حاضر ارتباط معکوسی بین سطح سرمی کورتیزول صبحگاهی با چاقی عمومی و شکمی وجود داشت، در حالی­که رابطه­ای بین سطح سرمی ویتامین C با چاقی مشاهده نشد. تا جایی که ما می­دانیم، این نوع مطالعه برای اولین بار در زنان ایرانی انجام شده است و مطالعات بیشتری برای تعیین ماهیت این رابطه نیاز است. 

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