بهره گیری از نانوحامل ها در دارورسانی پوستی

نوع مقاله: مروری

نویسندگان

1 گروه فارماسیوتیکس- دانشکده داروسازی

2 رزیدنت داروسازی بالینی،گروه داروسازی بالینی، دانشکده داروسازی، دانشگاه علوم پزشکی شهید بهشتی، تهران، ایران.

3 دانشجوی دکترای مهندسی شیمی.دانشکده مهندسی شیمی، دانشگاه علم و صنعت ایران، تهران، ایران.

10.22118/jsmj.2020.211687.1918

چکیده

زمینه و هدف: عبورپذیری تراپوستی به رساندن دارو به درون بدن از طریق پوست برای درمان موضعی یا عمومی اطلاق می شوند. داروهای جذب شده از راه تراپوستی فاقد اثر اول کبدی بوده و همچنین عاری از عوارض گوارشی هستند. استفاده از جذب افزاهای شیمیایی و همچنین سامانه های جذب افزای فیزیکی امروزه به دلیل گرانی و همچنین تغییرات بر روی پوست کمتر مورد استفاده هستند و نگاه آینده به استفاده از فناوری های نوین است. یکی از مهم ترین فناوری های نوین در حوزه ی دارورسانی تراپوستی بهره گیری از نانوحامل های دارویی است. فرمولاسیون های نانو ذراتی در حدود 10 تا 100 نانومتر داشته و ذرات کوچکتر جذب و عبورپذیری ساده تری از سطح پوست دارند. یافته ها: در پژوهش حاضر ضمن بررسی مطالعات گذشته پیرامون بهره گیری از فناوری نانو در سامانه های تراپوستی به معرفی آن ها و مکانسیم عبورپذیری تراپوستی آنها پرداخت شد. نتیجه گیری: فناوری نانو به شکل های مختلف و فرمولاسیون های متفاوت توانایی افزایش عبورپذیری تراپوستی داروها را دارد که بسته به ویژگی های آن ها، ویژگی های فیزیکوشیمیایی داروها و اهداف درمانی می توان هر یک را برگزید.

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