اثر بازتوانی با تمرینات ترکیبی منتخب بر بیان ترومبوسپوندین- 1 و اینترلوکین- 1 بتا در سلولهای تک هست های خون در بیماران مرد پس از جراحی بایپس عروق کرونر

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری، گروه فیزیولوژی ورزشی، واحد آیت الله آملی، دانشگاه آزاد اسلامی، آمل، ایران

2 دانشیار، گروه فیزیولوژی ورزشی، واحد آیت الله آملی، دانشگاه آزاد اسلامی، آمل، ایران

3 استادیار، گروه فیزیولوژی ورزشی، واحد آیت الله آملی، دانشگاه آزاد اسلامی، آمل، ایران

10.61186/jsmj.22.5.12

چکیده

مقدمه و هدف‌: پیوند بای پس عروق کرونر (CABG) مداخله درمانی متداولی است که در بیماران مبتلا به بیماری های عروق کرونر قلب انجام می گیرد. هدف این پژوهش تعیین اثر تمرینات بازتوانی ترکیبی منتخب بر بیان ژن‌های ترومبوسپوندین-1 (TSP-1) و اینترلوکین-1 بتا (IL-1β) در بیماران پس از جراحی بای پس عروق کرونری بود.
روش کار: در این مطالعه نیمه تجربی، 20 بیمار مرد از بیمارستان افشار (شهر یزد) پس از جراحی عروق کرونری به‌صورت هدفمند و در دسترس انتخاب و به‌طورتصادفی به دو گروه تمرینات ترکیبی و کنترل تقسیم ‌شدند. گروه برنامه تمرین ترکیبی شامل تمرین هوازی (به مدت 15 تا 20 دقیقه و با شدت 50 تا 60 درصد حداکثر ضربان قلب) و مقاومتی (به مدت 10 -20 دقیقه شامل سه حرکت اندام فوقانی و دو حرکت اندام تحتانی، هر حرکت شامل سه ست و هر ست با 10 تکرار و 30 تا 60 در صد یک تکرار بیشینه) به مدت 10 هفته (30 جلسه) و سه جلسه در هفته را انجام دادند. بیان ژن‌ یه روش Real Time PCR اندازه‌گیری شد. داده‌ها به روش آزمون تی زوجی و تحلیل کوواریانس در سطح معنی‌داری P<0.05 تجزیه و تحلیل شدند.
یافته‌ها: پس از دوره مداخله کاهش معنی داری در بیان IL-1β مشاهده شد ولی تفاوت معنی داری در بیان TSP-1 مشاهده نشد.
نتیجهگیری: تمرینات ترکیبی به‌عنوان یک مداخله غیردارویی توانبخشی، با کاهش التهاب سیستمیک می تواند در بیمارانی باشد که تحت CABG قرار گرفته‌اند، مفید باشد.

تازه های تحقیق

Maryam Monjezi [PumMed] [Google Scholar]

Alireza Barari [PumMed] [Google Scholar]

Ahmad Abdi [PumMed] [Google Scholar]

کلیدواژه‌ها

موضوعات


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