اثر داروی اتورواستاتین و تمرین هوازی تداومی بر بیان ژن فاکتور رشد اندوتلیال عروقی بتا در بافت کبد موشهای صحرایی دیابتی

نوع مقاله : مقاله پژوهشی

نویسندگان

1 گروه فیزیولوژی ورزشی، واحد آیت الله آملی، دانشگاه آزاد اسلامی، آمل، ایران

2 گروه فیزیولوژی ورزشی، واحد ساری، دانشگاه آزاد اسلامی، ساری، ایران.

10.61186/jsmj.22.3.9

چکیده

زمینه و هدف فاکتور رشد اندوتلیال عروقی بتا ) β-VEGF ( برخلاف نقش ضعیف در رگزایی در متابولیسم لیپید نقش دارد. هدف
تحقیق حاضر تعیین اثر تمرین و مصرف آتورواستاتین بر بیان ژن VEGF-β در بافت کبد موشهای صحرایی دیابتی بود.
روش بررسی در تحقیق حاضر 25 موش صحرایی نر نژاد ویستار در گروههای سالم کنترل، دیابت کنترل، دیابت + تمرین، دیابت
+ اتورواستاتین و دیابت + اتورواستاتین + تمرین تقسیم شدند. مداخلات شامل هشت هفته تمرین هوازی دویدن روی تریدمیل
و مصرف 10 میلی گرم اتورواستاتین بهصورت گاواژ بود. پس از مداخلات موشهای صحرایی قربانی شدند و بافت کبدی مورد
تجزیه و تحلیل قرار گرفت. تجزیه و تحلیل آماری با استفاده از روش آماری تحلیل واریانس یک طرفه و آزمون تعقیبی LSD انجام
شد.
یافته ها نتایج نشان داد که القای دیابت منجر به کاهش معنادار بیان ژن β-VEGF کبدی و افزایش گلوکز و کلسترول تام سرمی
نسبت به گروه سالم کنترل شد. در گروههای دیابت + تمرین و دیابت + اتورواستاتین + تمرین افزایش VEGF-β و کاهش گلوکز
و کلسترول نسبت به گروههای دیابت کنترل و دیابت + اتورواستاتین معنادار بود.
نتیجه گیری با توجه به نتایج میتوان گفت که تمرین هوازی تداومی میتواند با افزایش بیان ژن β-VEGF از عوارض کبدی ناشی
از دیابت جلوگیری کند، همچنین مصرف اتورواستاتین با وجود اثرات مثبت بر گلوکز و کلسترول تام سرمی، اثر معناداری بر بیان
ژن VEGF-β کبدی در موشهای صحرایی دیابتی ندارد.

تازه های تحقیق

Samaneh Ahmedpour [Google Scholar ]

AliReza Barari [PumMed] [Google Scholar ]

 Parvin Farzangi  [Google Scholar ]

کلیدواژه‌ها

موضوعات


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