52
Apr, May 2022. Volume 21. Number 1
[14] Sadoughi SD. [Comparing the effect of safranal and crocin
on serum levels of adiponectin, lipid profile and glucose in
healthy and type one diabetic rats (Persian)]. Pars J Med Sci.
2017; 15(3):49-59. [DOI:10.52547/jmj.15.3.8]
[15] Froutan B, Malzami S, Heratipour H, Malzami SH, Bolbol
haghighi N, Alam al-Hoda FS, et al. [Evaluation of palmatine effects
on cutaneous wound healing in normal and diabeticrats
(Persian)]. Iran J Diabetes Metab. 2014; 13(5):393-9. [Link]
[16] Moratalla-López N, Bagur MJ, Lorenzo C, Salinas MEMR,
Alonso GL. Bioactivity and bioavailability of the major metabolites
of Crocus sativus L. Flower. Molecules. 2019; 24(15):2827.
[DOI:10.3390/molecules24152827] [PMID] [PMCID]
[17] Vakili A, Eianali MR, Bandagi AR. [The protective effects of
Saffron against the oxidative damage in a transient model of
focal cerebral ischemia in rats (Persian)]. Tehran Univ Med J.
2011; 69(7):405-12. [Link]
[18] Milajerdi A, Mahmoudi M. [Review on the effects of saffron
extract and its constituents on factors related to nervous system,
cardiovascular and gastrointestinal diseases (Persian)].
Clin Exell. 2014; 3(1):108-27. [Link]
[19] Khorasani A, Hosseinimehr SJ, Zamani P, Ghasemi M, Ahmadi
A. The effect of saffron (Crocus sativus) extract for healing
of second-degree burn wounds in rats. Keio J Med. 2008;
57(4):190-5. [DOI:10.2302/kjm.57.190] [PMID]
[20] Kianbakht S. [A systematic review on pharmacology of saffron
and its active constituents (Persian)]. J Med Plants. 2008;
7(28):1-27. [DOI:20.1001.1.2717204.2008.7.28.1.3]
[21] Ali Rajabi A , Siah Kohian M , Akbarnejad A. Adaptation of irisin
serum levels, lipid profile and insulin resistance to a period
of aerobic exercise and oral consumption of saffron head and
its durability in obese women with type 2 diabetes. Basic and
clinical research journal 2018 ; 26(1): 9-26. [Link]
[22] Aktar N, Khan HMS, Ashraf S, Mohammad IS, Ali A. Skin depigmentation
activity of Crocus sativus extract cream. Trop J
Pharm Res. 2014; 13(11):1803-8. [DOI:10.4314/tjpr.v13i11.5]
[23] Vaghardoost R, Ghavami Y, Sobouti B. The effect of mentha
pulegium on healing of burn wound injuries in rat. World
J Plast Surg. 2019; 8(1):43-50. [DOI:10.29252/wjps.8.1.43]
[PMID] [PMCID]
[24] Florin L, Knebel J, Zigrino P, Vonderstrass B, Mauch C,
Schorpp-Kistner M, et al. Delayed wound healing and epidermal
hyperproliferation in mice lacking JunB in the skin. J Invest
Dermatol. 2006; 126(4):902-11. [DOI:10.1038/sj.jid.5700123]
[PMID]
[25] Mehrabi S, Shokrpoor M, Jamilian M, Sakhi H. [Evaluation of
the effect of saffron 20% cream on the level of infection and
episiotomy dehiscence (Persian)]. J Arak Univ Med Sci. 2015;
18(7):75-84. [Link]
[26] Yaghmayei P, Moshrefjavadi F, Nilforooshzade MA, Mardani
H, Kakanjadian P. [The effect of 2% alcohol green tea extract
on healing process of open wound in male mice (Persian)]. J
Isfahan Med Sch. 2009; 27(96):325-36. [Link]
[1] Bathaei Z, Makarizadeh N, Shirali D. A review of the mechanisms
of action of herbal active ingredients in the treatment
of diabetes mellitus.Journal of Medicinal Plants. 2013; 11(44):
1-24. [Link]
[2] Ashraf H, Heydari R, Nejati W, Ilkhanipour M. [Preventive effect
of berberis integerrima on the serum levels of glucose
and lipids in streptozotocin (stz)-induced diabetes in rats (Persian)].
J Adv Biomed Sci. 2012; 2(3):148-54. [Link]
[3] Ranjbar Heidari A, Khayyat-Zadeh J, Keshtahgar M. [Study of
root aqueous extract of Prosopis farcta effect on wound healing
of diabetic adult male rats (Persian)]. J Birjand Univ Med
Sci. 2012; 19(3):245-54. [Link]
[4] Nabiuni M, Oryan SH, Ayyobipor M, Bagheri A. [Histochemical
study of Verbascum speciocum extract's effects on the
wound healing in rats (Persian)]. J Cell Tissue. 2011; 2(1):67-
75. [DOI:10.29252/JCT.2.1.67]
[5] Nabiuni M, Azarnia M, Mousavi R, Ramezani T. [The effect
of Myrtus Communism leave extract cream on wound healing
process in Wistar rats (Persian)]. J Complement Med Res.
2014; 4(3):854-64. [Link]
[6] Miroliaei, M, Cheloongar, R, Aminjafari, A, Ghias, M. Histopathological
evaluation of non-infectious skin deep wound
healing activity of Melissa officinalis, Zizyphus spina-christi,
Althaea officinalis, Satureja bachtiarica extract. Cell Mol Res.
2017; 30(2):212-22.[DOR:20.1001.1.23832738.1396.30.2.9.0]
[7] Hoveizi E. [The effects of wharton's jelly mesenchymal stem
cells associated with gum of pistacia atlanticafor burn wound
healing (Persian)]. J Anim Physiol Dev. 2020; 13(3):85-96. [Link]
[8] Jaffary F, Nilforoushzadeh M A, Sharifian H, Mollabashi Z.
[Wound healing in animal models: Review article (Persian)].
Tehran Univ Med J. 2017; 75(7):471-9. [Link]
[9] Santos TS, Dos Santos IDD, Pereira-Filho RN, Gomes SVF, Lima-
Verde IB, Marques MN, et al. Histological evidence of wound
healing improvement in rats treated with oral administration
of hydroalcoholic extract of vitis labrusca. Curr Issues Mol Biol.
2021; 43(1):335-52. [DOI:10.3390/cimb43010028] [PMID]
[10] Shirvi H, Al-Buwayh M, Hojjati W, Akbari H. [The Effect of
Extract of Henna Leaves (Lawsonia inermis) on Skin Wound
Healing in Wistar Rats (Persian)]. J Anim Biol. 2011; 3(4):45-
52. [Link]
[11] Murshedi H, Ghaibi N, Safari, Ziaee A. [Effect of low-power
laser on wound healing and blood sugar in diabetic rats (Persian)].
J Isfahan Med School. 2014; 32(287): 756-67. [Link]
[12] Moodi H, Akbari A, Ghiasi F, Mahmoudzadeh H, Heidari Z,
Rashidi H. [The effect of Vacuum-Compression Therapy (VCT)
on the diabetic foot ulcer healing (Persian)]. J Adv Med Biomed
Res. 2006; 14(57):15-22. [Link]
[13] Samadi H, Javadi SH, Asri S. [Evaluation of the effects of
crocin on the serum levels of glucose, insulin, urea, creatinine
and β2m in healthy and streptozotocin-induced diabetic rats
(Persian)]. Stud Med Sci. 2015; 26(9):802-12. [Link]
Goli M, et al. The Effect of Crocin and Safranal on Skin Wound Healing . JSMJ. 2022; 21(1):42-53
53
Apr, May 2022. Volume 21. Number 1
[27] Ghorbani Z, Khadem E. Therapeutic applications of turmeric
and its principle constituent curcumin in wound healing and
skin regeneration from the perspective of conventional medicine
and iranian traditional medicine (ITM). J Med Plants.
2017; 16(64):12-21. [Link]
[28] Zarei L, Gheibi P, Karimipour M. [The effect of vitamin e on
histopathology of experimental burn wound healing in rats
(Persian)]. Qom Univ Med Sci J. 2015; 9(4):49-54. [Link]
[29] Abdullahzadeh A, Zarifkar A, Dehghan GA, Ay J. [Effects of
systemic administration of estrogen on the process of wound
healing in excisional wounds in diabetic rat (Persian)]. Stud
Med Sci. 2009; 20(1):26-33. [Link]
[30] Hadizadeh M, Malzami S, Bagheri M, Aminiyan M. [Effect of
alcohol extract of nigella sativa on wound healing in streptozotocin-
induced diabetic rat (Persian)]. J Diabetes Metab Disord.
2015; 16(2):77-84. [Link]
[31] Hajebrahimi Z, Naderi MS, Tabaie SM. [Study of gene expression
and nanotechnology in wound healing process (Persian)].
J Lasers Med. 2016; 13(2-3):50-63. [Link]
[32] Liu W, Sun Y, Cheng Z, Guo Y, Liu P, Wen Y. Crocin exerts antiinflammatory
and anti-arthritic effects on type II collagen-induced
arthritis in rats. Pharm Biol. 2018; 56(1):209-16. [DOI:1
0.1080/13880209.2018.1448874] [PMID] [PMCID]
[33] Afshar M, Sattari Fard H, Shadi M, Qaderi R. [Repairing effects
of Iran flora on wound healing (Persian)]. J Birjand Univ Med
Sci. 2015; 22(1):1-18. [Link]
[34] Thangavel P, Ramachandran B, Chakraborty S, Kannan
R, Lonchin S, Muthuvijayan V. Accelerated healing of diabetic
wounds treated with L-glutamic acid loaded hydrogels
through enhanced collagen deposition and angiogenesis: An
in vivo study. Sci Rep. 2017; 7(1):10701. [DOI:10.1038/s41598-
017-10882-1] [PMID] [PMCID]
[35] Bukhari SI, Manzoor M, Dhar MK. A comprehensive review of
the pharmacological potential of Crocus sativus and its bioactive
apocarotenoids. Biomed Pharmacother. 2018; 98:733-45.
[DOI:10.1016/j.biopha.2017.12.090] [PMID]
[36] Ataei G, Rahbarian R. [Investigating the effect of safranal
on Bax and Bcl2 and oxidative stress levels in testis tissue of
streptozotocin-induced diabetic rats (Persian)]. Feyz. 2020;
24(1):10-20. [Link]
[37] Deldar N, Monsefi M, Salmanpour M, Ostovar M, Heydari M.
Wound healing potential of crocin and safranal, main saffron
(Crocus sativus L.), the active constituents in excision wound
model in rats. Galen Medical J. 2021; 10:1-6. [DOI:10.31661/
gmj.v10i0.1900]
[38] Lahmass I, El Khoudri M, Ouahhoud S, Lahmass M, Khoulati
A, Benyoussef S, et al. Biological effects and pharmacological
activities of saffron of Crocus sativus. Arabian J Med Aromat
Plants. 2021; 7(2):254-68. [DOI:10.48347/IMIST.PRSM/ajmapv7i2.22962]
[39] Cai L, Xie L, Dong Q. Crocin enhances the viability of random
pattern skin flaps: Involvement of enhancing angiogenesis and
inhibiting oxidative stress. Am J Transl Res. 2020; 12(6):2929-
38. [PMID] [PMCID]
[40] Okonkwo UA, DiPietro LA. Diabetes and wound angiogenesis.
Int J Mol Sci. 2017; 18(7):1419. [DOI:10.3390/ijms18071419]
[PMID] [PMCID]
[41] Thanabalasuriar A, Chiang AJ, Morehouse C, Camara M,
Hawkins S, Keller AE, et al. PD-L1+ neutrophils contribute
to injury-induced infection susceptibility. Sci Adv. 2021;
7(10):eabd9436. [DOI:10.1126/sciadv.abd9436] [PMID] [PMCID]
[42] Mzabri I, Addi M, Berrichi A. Traditional and modern
uses of saffron (crocus sativus). Cosmetics. 2019; 6(4):63.
[DOI:10.3390/cosmetics6040063]
[43] Smith A, Watkins T, Theocharidis G, Lang I, Leschinsky M,
Maione A, et al. A novel three-dimensional skin disease
model to assess macrophage function in diabetes. Tissue
Eng Part C Methods. 2021; 27(2):49-58. [DOI:10.1089/ten.
tec.2020.0263] [PMID] [PMCID]
[44] Krzyszczyk P, Schloss R, Palmer A, Berthiaume F. The role of
macrophages in acute and chronic wound healing and interventions
to promote pro-wound healing phenotypes. Front
Physiol. 2018; 9:419. [DOI:10.3389/fphys.2018.00419] [PMID]
[PMCID]
[45] Lotfollahi Z, Dawson J, Fitridge R, Bursill C. The anti-inflammatory
and pro-angiogenic properties of high-density lipoproteins
(HDL): An emerging role in diabetic wound healing.
Adv Wound Care (New Rochelle). 2021; 10(7):370-86.
[DOI:10.1089/wound.2020.1308] [PMID]
[46] Limandjaja GC, van den Broek LJ, Waaijman T, van Veen HA,
Everts V, Monstrey S, et al. Increased epidermal thickness and
abnormal epidermal differentiation in keloid scars. Br J Dermatol.
2017; 176(1):116-26. [DOI:10.1111/bjd.14844] [PMID]