مجله علمی پزشکی جندی شاپور

مجله علمی پزشکی جندی شاپور

کاربرد روش‌های پروتئومیکس و ترنسکریپتومیکس در شناسایی ترکیبات غده زهری عقرب‌ها برای توسعه داروهای نوین

نوع مقاله : مروری

نویسنده
مرکز تحقیقات سم شناسی، پژوهشکده علوم پایه پزشکی، دانشگاه علوم پزشکی جندی شاپور اهواز ، اهواز، ایران.
چکیده
غدد زهری عقرب‌ها منبعی غنی و ارزشمند از ترکیبات فعال زیستی است که غالب این ترکیبات را پپتیدها و پروتئینهای متنوع تشکیل می‌‌دهند. قابلیت درمانی بسیاری از این ترکیبات نیز بررسی شده است. بنابراین، شناسایی ترکیبات غده زهری عقرب‌ها می‌تواند کاندیدهای جدید دارویی را برای توسعه داروهای نوین میسر کند. علاوهبر کشف داروهای جدید، یکی دیگر از مهم‌ترین کاربردهای شناسایی ترکیبات غده زهری عقرب، تشخیص عوامل مؤثر در مسمومیت برای تولید پادزهرهای اختصاصی برای درمان عقربزدگی است. به‌کارگیری روش‌های جدید برای شناسایی ترکیبات غده زهری عقرب‌ها می‌تواند دقت، کارایی و بازده را افزایش دهد. روش‌های ترانسکریپتومیکس و پروتئومیکس در سال‌های اخیر امکان شناسایی جامع‌تر این ترکیبات را فراهم کرده است. ترانسکریپتومیکس با تحلیل بیان ژن‌ها در غده زهری، اطلاعات دقیقی درباره پپتیدها و توکسین‌های زهری ارائه می‌دهد، درحالیکه پروتئومیکس با شناسایی مستقیم پروتئین‌ها و بررسی تغییرات پس‌ترجمه‌ای، داده‌های مکمل و تکمیلی فراهم می‌کند. ادغام این دو متد، که با عنوان ونومیکس شناخته شده است، دیدگاهی یکپارچه از ساختار و عملکرد مولکولی سم عقرب به دست می‌دهد و به کشف ترکیبات نوینی منجر شده است که می‌توانند در طراحی داروهای جدید علیه گستره وسیعی از بیماریها، چون سرطانها، عفونت‌های باکتریایی مقاوم و اختلالات عصبی، استفاده شوند. این مقاله مروری نقش کلیدی این فناوری‌ها را در شناسایی ترکیبات غده زهری عقرب‌ها بررسی و درباره چشم‌اندازهای آینده در کاربردهای دارویی و زیست‌فناورانه بحث می‌کند.
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  • تاریخ دریافت 10 مهر 1404
  • تاریخ بازنگری 20 آبان 1404
  • تاریخ پذیرش 24 آبان 1404