Background and Objective: Migraine is a recurring headache that its severity varies from moderate to high. Preventive treatments are recommended to treat migraine headaches. Among drugs used for prevention include sodium valproate and magnesium sulfate.
Subjects and Methods: In this study, 65 patients aged 18 to 50 years with a history of acute migraine migraine attacks were enrolled and divided into two groups. Prescribing and administering medicine was done by one person and evaluation of symptoms and visual analog scale (VAS) was performed by a second person without the knowledge of the prescribed medicine. Then, the effect of these drugs in terms of VAS reduction was evaluated half hour after injection and after 1 and 2 hours later and recorded in the checklist. The data were analyzed with SPSS.v11 statistical software.
Results: The mean age of patients was 36.11 SD=10.97. About 60% of patients had a positive family history of migraine disease. Results revealed that 97.1% of patients had nausea and 49.3% had vomiting. Also, magnesium sulfate and sodium valproate groups were not significantly different at half, one and two hours after injection and before injection (P=0.999, 0.788 =0.783 respectively).
Conclusion: This study showed that there is no significant difference in the severity of pain reduction in acute migraine attacks between sodium valproate and magnesium sulfate groups. Therefore, the use of either of these two drugs does not differ in the improvement of pain in the patient
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