Effect of hydrotherapy on brain-derived neurotrophic factor in children with an Autism Spectrum disorders

Document Type : Original Article

Authors

1 Department of Physical Education and Sport Sciences, Faculty of Humanities, Rasht Branch, Islamic Azad University, Rasht, Iran

2 Institute of Nursing and Health Research, Ulster University, N. Ireland

3 Department of Physical Education and Sport Sciences, Faculty of Humanities, Islamic Azad University, Rasht Branch, Rasht, Iran

Abstract

Hydrotherapy has positive effects on the behavior of people with autism. Studies have shown that BDNF plays an important role in autism neurobiology. The aim of this study was to determine the effect of hydrotherapy on the BDNF level in children with autism spectrum disorders. In this semi-experimental study, a pretest-posttest, control-group design was applied. A total of 32 participants were randomly assigned to the control (n, 16) and experimental (n, 16) groups. The Halliwick intervention continued for eight weeks, three sessions per week for 60 minutes. Blood samples were collected to measure the BDNF level before and after eight weeks of intervention. There was no significant difference between BDNF in pre-test and post-test in control group and experimental groups. There was no significant difference between BDNF levels the control and experimental groups in the pre-test and post-test. (P≤0.05) According to the results, Hydrotherapy on serum BDNF level does not have a significant effect on children with autism spectrum disorders.

Keywords


1-Association AP. Diagnostic and statistical manual of mental disorders (DSM-5®): American Psychiatric Pub; 2013.
2-Baio J. Prevalence of autism spectrum disorder among children aged 8 years-autism and developmental disabilities monitoring network, 11 sites, United States, 2010. 2014;2(63):1-21.
3-Samadi SA, Mohammad MP, Ghanimi F, McConkey R. The challenges of screening pre-school children for autism spectrum disorders in Iran. Disability and rehabilitation. 2016;38(17):1739-47.
4-Raznahan A, Toro R, Proitsi P, Powell J, Paus T, P FB, et al. A functional polymorphism of the brain derived neurotrophic factor gene and cortical anatomy in autism spectrum disorder. Journal of neurodevelopmental disorders. 2009;1(3):215-23.
5-Chapleau CA, Larimore JL, Theibert A, Pozzo-Miller L. Modulation of dendritic spine development and plasticity by BDNF and vesicular trafficking: fundamental roles in neurodevelopmental disorders associated with mental retardation and autism. Journal of neurodevelopmental disorders. 2009;1(3):185-96.
6-Binder DK, Scharfman HE. Brain-derived neurotrophic factor. Growth factors (Chur, Switzerland). 2004;22(3):123.
7-Bamji SX, Rico B, Kimes N, Reichardt LF. BDNF mobilizes synaptic vesicles and enhances synapse formation by disrupting cadherin–β-catenin interactions. J Cell Biol. 2006;174(2):289-99.
8-Lu B, Chow A. Neurotrophins and hippocampal synaptic transmission and plasticity. Journal of neuroscience research. 1999;58(1):76-87.
9-Yamamoto H, Gurney ME. Human platelets contain brain-derived neurotrophic factor. Journal of Neuroscience. 1990;10(11):3469-78.
10-Hyman C, Hofer M, Barde Y-A, Juhasz M, Yancopoulos GD, Squinto SP, et al. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature. 1991;350(6315):230.
11-Anderson GM, Lombroso PJ. Genetics of childhood disorders: XLV. Autism, part 4: serotonin in autism. Journal of the American Academy of Child & Adolescent Psychiatry. 2002;41(12):1513-6.
12-Hashimoto K, Shimizu E, Iyo M. Critical role of brain-derived neurotrophic factor in mood disorders. Brain research reviews. 2004;45(2):104-14.
13-Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ. Transport of brain-derived neurotrophic factor across the blood–brain barrier. Neuropharmacology. 1998;37(12):1553-61.
14-Karege F, Schwald M, Cisse M. Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neuroscience letters. 2002;328(3):261-4.
15-Hashimoto K, Iwata Y, Nakamura K, Tsujii M, Tsuchiya KJ, Sekine Y, et al. Reduced serum levels of brain-derived neurotrophic factor in adult male patients with autism. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2006;30(8):1529-31.
16-Katoh-Semba R, Wakako R, Komori T, Shigemi H, Miyazaki N, Ito H, et al. Age-related changes in BDNF protein levels in human serum: differences between autism cases and normal controls. International Journal of Developmental Neuroscience. 2007;25(6):367-72.
17-Das UN. Nutritional factors in the pathobiology of autism. Nutrition. 2013;29(7/8):1066.
18-Griffin ÉW, Mullally S, Foley C, Warmington SA, O'Mara SM, Kelly ÁM. Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males. Physiology & behavior. 2011;104(5):934-41.
19-Gould E, McEwen BS, Tanapat P, Galea LA, Fuchs E. Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. Journal of Neuroscience. 1997;17(7):2492-8.
20-Ruscheweyh R, Willemer C, Krüger K, Duning T, Warnecke T, Sommer J, et al. Physical activity and memory functions: an interventional study. Neurobiology of aging. 2011;32(7):1304-19.
21-Zoladz J, Pilc A, Majerczak J, Grandys M, Zapart-Bukowska J, Duda K. Endurance training increases plasma brain-derived neurotrophic factor concentration in young healthy men. J Physiol Pharmacol. 2008;59(Suppl 7):119-32.
22-Rimmer JA, Rowland JL. Physical activity for youth with disabilities: a critical need in an underserved population. Developmental Neurorehabilitation. 2008;11(2):141-8.
23-C-Y. Effects of water exercise swimming program on aquatic skills and social behaviors in children with autism spectrum disorders. Autism. 2010;14(1):9-28.
24-J. M. The Halliwick Method. Physiotherapy. 1981 67(10):288-91.
25-Rojas Vega S, Struder HK, Vera Wahrmann B, Schmidt A, Bloch W, Hollmann W. Acute BDNF and cortisol response to low intensity exercise and following ramp incremental exercise to exhaustion in humans. Brain research. 2006;1121(1):59-65.
26-Bansi J, Bloch W, Gamper U, Riedel S, Kesselring J. Endurance training in MS: short-term immune responses and their relation to cardiorespiratory fitness, health-related quality of life, and fatigue. Journal of neurology. 2013;260(12):2993-3001.
27-Briken S, Rosenkranz SC, Keminer O, Patra S, Ketels G, Heesen C, et al. Effects of exercise on Irisin, BDNF and IL-6 serum levels in patients with progressive multiple sclerosis. Journal of neuroimmunology. 2016;299:53-8.
28-Angelucci F, Piermaria J, Gelfo F, Shofany J, Tramontano M, Fiore M, et al. The effects of motor rehabilitation training on clinical symptoms and serum BDNF levels in Parkinson's disease subjects. Canadian journal of physiology and pharmacology. 2016;94(4):455-61.
29-Castellano V, White LJ. Serum brain-derived neurotrophic factor response to aerobic exercise in multiple sclerosis. Journal of the neurological sciences. 2008;269(1):85-91.
30-Schulz K-H, Gold SM, Witte J, Bartsch K, Lang UE, Hellweg R, et al. Impact of aerobic training on immune-endocrine parameters, neurotrophic factors, quality of life and coordinative function in multiple sclerosis. Journal of the neurological sciences. 2004;225(1-2):11-8.
31-Mohammadi ZF, Talebi V, mojtaba Hosseini S, Mohammadi HF, Patel DI. Pretreatment Effect of a 6-week Swimming Training protocol along with Vitamin D administration on the brain levels of BDNF, TNF-α and IL-10 in Rats Model of EAE. International Journal of Applied Exercise Physiology. 2019;8(1):51-8.
32-Knaepen K, Goekint M, Heyman EM, Meeusen R. Neuroplasticity—exercise-induced response of peripheral brain-derived neurotrophic factor. Sports medicine. 2010;40(9):765-801.
33-Szuhany KL, Bugatti M, Otto MW. A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor. Journal of psychiatric research. 2015;60:56-64.
34-Lommatzsch M, Zingler D, Schuhbaeck K, Schloetcke K, Zingler C, Schuff-Werner P, et al. The impact of age, weight and gender on BDNF levels in human platelets and plasma. Neurobiology of aging. 2005;26(1):115-23.
35-Mang CS, Campbell KL, Ross CJ, Boyd LA. Promoting neuroplasticity for motor rehabilitation after stroke: considering the effects of aerobic exercise and genetic variation on brain-derived neurotrophic factor. Physical therapy. 2013;93(12):1707-16
36-Persson N, Lavebratt C, Wahlin Å. Synergy effects of HbA1c and variants of APOE and BDNFVal66Met explains individual differences in memory performance. Neurobiology of learning and memory. 2013;106:274-82