Prevalence of Metabolic Syndrome and its Predicting Factors in Type 2 Diabetic Patients in Ahvaz

Document Type : Original Article

Authors

1 Assistant Professor of Endocrinology.Department of Endocrinology, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

2 Resident of Internal medicine.Department of Endocrinology, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

3 Associate Professor of Endocrinology.Department of Endocrinology, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

4 Lecturer of Epidemiology and Biostatistics.Department of Epidemiology and Biostatistics, Diabetes Research Center, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

5 Associate Professor of Nutrition. Department of Nutrition, Faculty of Paramedicine, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Abstract

Background and Objective: Metabolic syndrome (MetS) is one of the most important risk factors of Type 2 Diabetes Mellitus (T2DM) and Ischemic heart disease. The aim of this study was to survey the prevalence of MetS among in T2DM patients and to compare the value of its predicting factors according to ATP III and IDF criteria.
Subjects and Methods: In this was a cross-sectional study on 350 adult T2DM patients selected with simple random sampling from Ahvaz Diabetic Research Center Clinic in 2010, were selected by simple random sampling. Data were collected by a questionnaire and measurement of HDL, cholesterol, triglyceride and detection of mircoalbuminuria.  The data were analyzed by independent t-test, chi-score, and multivariate logistic regression with SPSS 18.
Results: Prevalence of MetS according to ATP III and IDF criteria was 73.1% and 64.9% respectively (κ=0.675). With regard to both criteria, the peak prevalence of MetS was in the age group 50-59 year. HDL cholesterol had higher prevalence and odds ratio than other factors. Female gender, physical activity, microalbuminuria, triglyceride and HDL cholesterol had higher value of prediction for MetS than others.
Conclusion: Prevalenceof MetS in T2DM is high and female gender, physical activity, microalbuminuria, triglyceride and HDL were the predicting factors of MetS.

Keywords


1-Chen K, Lindsey JB, Khera A, De Lemos JA, Ayers CR, Goyal A, et al. Independent associations between metabolic syndrome, diabetes mellitus and atherosclerosis: observations from the Dallas Heart Study. Dia Vasc Dis Res 2008;5:96–101.
2-Liu SJ, Guo ZR, Hu XS, WU M, Chen FM, Kang GD, et al. Risks for type-2 diabetes associated with the metabolic syndrome and the interaction between impaired fasting glucose and other components of metabolic syndrome the study from Jiangsu, China of 5 years follow-up. Diabetes Res Clin Pract 2008;81: 117-23.
3-Song SH, Hardisty CA. Diagnosing metabolic syndrome in type 2 diabetes: does it matter? QJM 2008;101:487 -91.
4-Janghorbani M, Amini M. Metabolic syndrome in type 2 diabetes mellitus in isfahan, Iran: prevalence and risk factors. Metab Syndr Relat Disord 2007; 5: 243-54.
5-Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2005; 365:1415-28.
6-Cameron AJ, Shaw JE, Zimmet PZ. The metabolic syndrome: prevalence in worldwide populations. Endocrinol Metab Clin North Am 2004;33: 351-75.
7-Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001;285:2486–97.
8-Alberti KG, Zimmet P, Shaw J. The metabolic syndrome--a new worldwide definition. Lancet 2005;366:1059-62.
9-Kim WY, Kim JE, Choi YJ, Huh KB. Nutritional risk and metabolic syndrome in Korean type 2 diabetes mellitus. Asia Pac J Clin Nutr 2008;17:47-51.
10-Ford ES. Prevalence of the metabolic syndrome in US populations. Endocrinol Metab Clin North Am 2004;33: 333-50.
11-Targher G, Bertolini L, Tessari R, Zenari L, Araco G. The International Diabetes Federation definition of the metabolic syndrome independently predicts future cardiovascular events in Type 2 diabetic patients. The Valpolicella Heart Diabetes Study. Diabet Med 2006;23: 1270-1.
 
12-Monami M,Marchionni N, Masotti G, Mannucci E. IDF and ATP-III definitions of metabolic syndrome in the prediction of all-cause mortality in type 2 diabetic patients. Diabetes Obes Metab 2007;9:350-3.
13-Sone H, Tanaka S, Ishibashi S, Yamasaki Y, Oikawa S, Ito H, et al. The new worldwide definition of metabolic syndrome is not a better diagnostic predictor of cardiovascular disease in Japanese diabetic patients than the existing definitions: additional analysis from the Japan Diabetes Complications Study. Diabetes Care 2006;29:145-7.
14-Jalali R, Vasheghani M, Dabbaghmanesh MH, Ranjbar Omrani Gh. Prevalence of metabolic syndrome among adults in a rural area. Iranian J Endocrin Metab 2009;11:405-14.