A Study of the Effect of Apium graveolens Hydroalcoholic Extract on Formalin-induced Inflammation in Male Rat Hind Paw

Document Type : Original Article

Authors

1 Department of Pharmacology, Toxicology, School of Pharmacy, Physiology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

2 School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

3 Deparment of

Abstract

Background and Objectives: The aim of this study was to compare the inflammatory effect of hydroalcoholic extract of Apium graveolens with aspirin.
Subject and Methods:  The plant was collected from Dezful gardens. Hydroalcoholic extract of Apium graveolens powder was macetrated in ethanol 70% (v/v). Animals were divided into 6 groups (10 for each). Negative group received 5ml/kg normal saline, the positive group received 300 mg/kg aspirin and extract-treated groups received 100, 200, 400, 600 mg/kg of hydroalcoholic extract of Apium graveolens (IP) respectively. Thirty minutes later all groups received 100 µl formalin 2.5% (SC, in hind paw). Hid paw vulome was measured for five hours in intervals of one hour using plethysmometer.
Results: All extract-treated groups showed dose-dependent anti-inflammatory effect. There were no significant differences between the groups that received 400 and 600 mg/kg extract with those received aspirin.
Conclusion: The hydroalcoholic extract of Apium graveolensshowed anti-inflammatory effect that was dose-dependent.
 

Keywords

References

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Jundishapur Scientific Medical Journal
Volume 13, Issue 2 - Serial Number 89
July and August 2014
Pages 225-232

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History

  • Receive Date: 03 July 2013
  • Revise Date: 24 November 2013
  • Accept Date: 15 December 2013

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