Effects of midazolam and dexmedetomidine on sedation levels, hemodynamics and, complications under brain stereotaxic surgery.

Document Type : Original Article


1 Assistant professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

2 Department of Anesthesiology and Critical Care, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

3 School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran


Background: Sedation in critical surgeries such as brain stereotaxic surgeries is an important issue due to the need for hemodynamic stability of the patients. Midazolam and dexmedetomidine account as important sedative drugs in clinic. Their role as sedatives are well proven in different studies but there has been no previous study, comparing their influence on hemodynamic and post operation complication in brain stereotaxic surgery.
Methods: In this clinical trial, 64 patients candidate for brain stereotaxic surgery went under sedation with midazolam and dexmedetomidine and hemodynamic values such as systolic and diastolic blood pressure, heart rate, respiratory rate, sedation level, patient and surgeon satisfaction, recovery time after surgery and post operation complications were evaluated and collected and data were analyzed.
Results: In both groups (midazolam and dexmedetomidine) mean systolic and diastolic blood pressure and heart rate had no differences but respiratory rate in midazolam group was lower than dexmedetomidine group and they also experienced more frequent apnea episodes and decreased O2 saturation.
Conclusion: Dexmedetomidine is safer drug in comparison to midazolam and use of this drug is suggested in those critical surgeries such as brain stereotaxic surgeries in which hemodynamic stabilities are important. And dexmedetomidine causes fewer respiratory complications than midazolam.


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