A study on the pathological indices reports of neuroendocrine tumors registered in Shahid Sadoughi Hospital, Yazd from 2011 to 2015 and comparing it with standard pathological indices

Document Type : Original Article


1 Resident of Ophthalmology, Kermanshah University of Medical Sciences, Kermanshah, Iran

2 Department of Pathology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

3 School of Medicine, Shahid Sadoughi university of medical sciences, Yazd, Iran

4 Medical Student, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

5 Medical Student, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran


Introduction: Neuroendocrine tumors (NETs) originate from peptide and amine producing cells of neuroendocrine system. Data presented in pathology reports, determine the prognosis and therapeutic approach of patients. The aim of this study was to investigate that how these indicators are reported in Shahid Sadoughi Hoaspital.
Methods: In this cross-sectional and descriptive study, all neuroendocrine tumors reported by pathology department of Shahid Sadoughi Hospital, were studied by census method from 2011 to 2015. Finally, 73 cases were studied regarding pathologic standard indices including pathology diagnosis, anatomic origin of the tumor, amount of mitosis, immunohistochemical staining, immunohistochemical staining type, determination of Ki67 index, the status of necrosis, vascular and perineural invasion.
Findings: Among 73 investigated pathology reports, small cell carcinoma was the most common pathologic diagnosis with 46.6% of cases. The most common anatomic site was respiratory system with 49.3% of cases. Amount of mitosis, Ki67 index, the status of necrosis and vascular, perineural invasion were mentioned in 31.5%, 28.8%, 34.2% and 15.1% of pathology reports respectively.
Discussion: According to the results, most pathologic reports of neuroendocrine tumors lack one or more factors that is necessary for reporting. However, these factors are pivotal for determination of prognosis and therapeutic approach in patients.


1-Demir R, Pohl J, Agaimy A, Peros G, et al.Necrosis and angioinvasion predict adverse outcome in pancreatic neuroendocrine tumors after curative surgical resection: results of a single-center series. See comment in PubMed Commons below2011;35(12):2764-72.
2-Tirgary F, Jahanzad I, Yazdani F. Neuroendocrine carcinoma tumors of immunohistochemistry department of “Cancer institute” in 1996-2000. Tehran University Medical Journal (TUMJ) 2003; 61(2): 90-94.
3-Klimstra DS, Modlin IR, Coppola D et al. The pathologic classification of neuroendocrine tumors: A review of nomenclature, grading, and staging systems. Pancreas 2010; 39: 707–712 .
4-Sadighi S, Roshanaee GH,Vahedi S, Jahanzad E, MohagheghiMA,  Jarahi A.   Neuroendocrine  tumors  in  Iran  Cancer  Institute: Predictive factors of patient survival.  Asian Pac J Cancer 2014;15:7835-8.
5-Alsina, Maria; Marcos-Gragera, Rafa ; et al el .Neuroendocrine tumors: A population-based study of incidence and survival in Girona province, 1994-2004. Cancer Epidemiology 35.6  (2011): e49-54 .
6-Alsina M, Marcos-Gragera R, Capdevila J, Buxó M, Ortiz RM, Barretina P, et al. Neuroendocrine tumors: a population-based study of incidence and survival in Girona Province, 1994–2004. Cancer epidemiology. 2011;35(6):e49-e54.
8-Rindi G, Klersy C, Inzani F, Fellegara et al . Grading the neuroendocrine tumors of the lung: an evidence-based proposal. Endocrine Related Cancer 2013 Dec 16;21(1):1-16.
9-Koji Ikeda ,Motohiro Kojima, Norio Saito et al. Current status of the histopathological assessment, diagnosis, and reporting of colorectal neuroendocrine tumors: A Web survey from the Japanese Society for Cancer of Colon and Rectum .international pathology  2016 Íž  66(2) : 94-101.