Effect of 6 weeks aerobic training on peripheral neuropathic pain to inhibition of expression of Notch-1 receptor and JAK/STAT signaling pathway in posterior spinal cord of diabetic male rats

Document Type : Original Article


1 Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran

2 Assistant Professor of Sport Physiology.Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran.

3 Associate Professor of Sport Physiology.Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran.


Introduction:The peripheral Neuropathic pain is one of the largely untreated pains which physical activity is consider of the main streams as a treatment for it . The purpose of this study was the effect of six weeks aerobic training on peripheral neuropathic pain and expression of the NOTCH1 receptor and JAK/STAT pathway in the spinal cord of diabetic male rats.

Methods:40 male Wistar rats (age: 8 weeks old; weight 220±10/2g) were randomly divided into 4 groups: diabetic neuropathy training (DNT), diabetic neuropathy control (DNC), healthy training (HT) and healthy control (HC). two weeks after induction of diabetes, behavioral pain tests were administered and endurance training protocol was performed for 6 weeks To evaluate the expression of NOTCH1 ,IL6,TNF-a and STAT3 was used Real Time PCR technique. And used one-way ANOVA and significant level was P <0.05

Results: After 6 weeks of aerobic training, the expression of NOTCH1 ,IL6,TNF-a and STAT3 genes in diabetic training group was significantly lower than the diabetic neuropathy control group. The mean weight of the diabetic training group was more than the diabetic control group. Also, exercise significantly decreased blood glucose levels in the diabetic group.

Conclusion: It seems that aerobic exercise on rats with diabetic can effect on pain sensation and the levels of NOTCH1 ,IL6,TNF-a and STAT3 factors, and aerobic exercise is a suitable method for preventing, controlling and treating pain associated with diabetes.


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