The effect of six weeks aerobic training on Serum and muscle levels of ascorbic acid and SVCT2 of soleus muscle tissue in Wistar rats

Document Type : Original Article


1 Faculty of Physical Education and Sport Sciences, Kharazmi University, Tehran, Iran.

2 Department of Exercise Physiology, Faculty of Sport Sciences, University of Kharazmi, Tehran, Iran

3 Department of Sport Physiology, Kharazmi University, Tehran, Iran


Introduction: Sodium-dependent vitamin C transporter 2 (SVCT2) plays an important role in the transfer of ascorbic acid to slow-twitch fiber. Due to the importance of ascorbic acid in muscle fibers and the role of SVCT2 in the transmission of this vitamin, the purpose of this study was to investigate the effect of aerobic training on serum and tissue ascorbic acid levels and SVCT2 levels in Soleus muscle in experimental rats.
Methods: In this experimental study, 10 male Wistar rats were randomly divided into two groups: aerobic training and control. Aerobic group, training for 6 weeks of aerobic running on Treadmill, 5 sessions per week and each training session for 20-40 minutes were performed for 10-20 meter per minutes . Homogeneous tissue of soleus muscle and serum were analyzed to evaluate the effect of exercise training on ascorbic acid metabolism. Data were analyzed by independent t-test and covariance analysis (P ≤ 0.05).
Results: The results showed that there was no significant difference between the level of SVCT2 of Soleus muscle and also the levels of serum and muscle ascorbic acid when compared with control group (P> 0.05).
Discussion and Conclusion: Regarding the results of this study, it can be concluded that 6 weeks of aerobic exercise have no significant effect on serum and muscle ascorbic acid levels and muscle levels of SVCT2 in experimental rats. And slow-twitch muscle in healthy rats does not have any limits on the production of ascorbic acid and the supply of ascorbic acid.


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