The effect of 6 weeks of continuous aerobic exercise on insulin resistance, nitric oxide and some lipid profiles of diabetic male rats

Document Type : Original Article


1 PhD Student in exercise physiology, Department of exercise physiology, Faculty of Physical Education, Kharazmi University, Tehran, Iran.

2 Professor of Physiology, Department of Physiology, School of Medicine, Ahvaz Jundishapur University of Medical sciences, Ahvaz, Iran.

3 Professor of exercise physiology , Department of exercise physiology, Faculty of Physical Education, Kharazmi University, Tehran, Iran.


Objective: Diabetes mellitus is one of the most important metabolic diseases with endothelial dysfunction. And appropriate physical activity is recommended as a non-pharmacological treatment. Therefore, the purpose of this study was to investigate the effect of continuous aerobic exercise on serum nitric oxide levels, insulin resistance, and some lipid profiles in diabetic male rats.
Methods: We randomly divided 60 male Wistar rats into 6 groups of 10 rats per group - control, sham, aerobic, aerobic+salin, diabet, diabet-aerobic. Diabetes was induced by intra-peritoneal injection of streptozotocin - nicotinamide. The subjects used treadmill training for 6 weeks and 5 sessions per week. The rats were killed 48 h after the last training session and was measured the levels of glucose, insulin, NO, HOMA-IR, LDL, HDL, TG and cholesterol. One-way ANOVA was used for statistical analysis (p<0.05).
Results: Diabetes increased the levels of glucose and HOMA-IR, whereas it significantly reduced insulin and NO levels. After 6 weeks of aerobic training, glucose and insulin resistance decreased and nitric oxide levels increased compared with the diabetes group. But there was no effect on the level of insulin. Also, 6 week aerobic training did not have a significant effect on lipid factors in different groups(p<0.05).
Conclusion: Conclusion: It seems that aerobic exercise can with effect on vascular function have a protective effect on vascular diseases in diabetic patients.


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Volume 17, Issue 4 - Serial Number 115
November and December 2018
Pages 401-413
  • Receive Date: 28 November 2018
  • Revise Date: 09 December 2018
  • Accept Date: 09 December 2018