A Study On The Relationship between Total Salivary Antioxidant Level and Periodontal Disease

Document Type : Original Article

Authors

1 Assistant Professor of Periodontics.Department of Periodontal Dentistry, School of Dentistry, Ahvaz University of Medical Sciences, Iran.

2 Assistant Professor of Restorative.Department of Operative Dentistry, School of Dentistry, Ahvaz University of Medical Sciences, Iran.

3 Resident of Restorative. Resident of Restorative Dentistry, School of Dentistry, Ahvaz University of Medical Sciences, Iran.

4 Dentist.

Abstract

Background and Objective: Increase in free radicals leads to oxidative stress which is implicated in the pathogenesis of many systemic and oral diseases such as periodontal disease. The aim of this study was to find the relationship between the salivary total antioxidant level and periodontal disease. 
Subjects and Methods: This case control study included 15 patients with periodontitis, 15 patients with gingivitis and 15 controls were recruited from patients referring to Ahwaz Dental School in 1390-1391. The levels of salivary total antioxidants were evaluated using Spectrophotometry method.
Results: Control group had significantly higher total salivary antioxidant level compared with patients with gingivitis and periodontitis (P<0.001).The difference between total salivary antioxidant level in patients with gingivitis and periodontitis was not significant (P>0.05).
Conclusion: The findings demonstrate an inverse relationship between total antioxidant level with development of periodontitis and gingivitis.

Keywords

References

1-Thomas JA, Shills ME, Olson JA, Shike M, Roos AC. Modern nutrition in health and disease. J Nutr 2006; 1: 685-69
2-Micheal GN, Herry HT, Perry RK. Text book of clinical periodontology.10th ed. Newyork; Saunders Elsevier 2006: 172-160
3-Iain IC Chapple, Mike R, Milward DR, Thomas DR. The prevalence of inflammatory periodontitis is negatively Assosiated with serum antioxidant. J Nutr 2007; 13(7): 657-646
4-Chapple IL, Matthews JB. The role of reactive oxygen & antioxidant species in periodontal tissue destruction. perio2000.2007; 43:160-232.
5-Krajcovicova – Kudlackova  M, Valachovicova  M, Paukova V, Dusinska M. Effects of diet and age on oxidative damage products in healthy subjects. Physiol Res 2008; 57: 647-651.
6-Kim Sc, Kim Os. Kim Oj, Kim Yj, Chung Hj. Antioxidant profile of whole saliva after scaling and root planning in periodontal disease. J Periodontal Impl Sci 2010; 40(4):164-171.
7-Battino M, Ferreiro MS, Gallordo I, Newman HN, Bullon P. The antioxidant capacity of saliva. J clin perio2002 mar; 29(3):189-194
8-Nagler RM, Klein I, Zarzhevsky N, Drigues N, Rezinck A. Characterization of the differentiated antioxidant profile of human saliva. Free Rad Bio&Med2002; 32(3): 268-277.
9-Brock GR, Butterworth CJ, Mattews JB, Chapple IL. Local and systemic total antioxidant capacity in periodontitis and health. J clin periodontal 2004; 31(7) 515- 521.
10-Dean VS, Simon CL. Periodontal disease is associated with lower antioxidant capacity in whole saliva and evidence of increased protein oxidation. J Clin Sci (lond) 2003; 105(2): 167-72.
11-Ulku B, Hikmet GL, Emine C, Evin A, Funda Y. Plasma and salivary total antioxidant capacity in healthy controls compared with aggressive and chronic periodontitis patients. Saudi Med J2015 Jul; 36(7): 856-861.
12-Moore S, Cader KAC, Millar NJ, Rice-evans CA. Antioxidant activity of saliva and periodontal disease. Free radical Res1994; 21: 417-425.
13-Nuttall NM, Steele JG, Pine CM, White D, Pitts NB. The impact of oral health on people in the UK. British Dental journal2001; 190:121-126.
14-Diab-Ladki R, Pellat B, Chahine R. Decrease in the total antioxidant activity of saliva in patient with periodontal diseases. Clin Oral Invest 2003; (2), 103-107.
15-Chapple IL, Mason GI, Garner I, Matthew JB, Thrope GH, Maxwell SRJ, Whitehead TP. Enhanced chemiluminescent assay for measuring the total antioxidant capacity of serum ,saliva and crevicular fluid. Ann clin Biochem1997; 34: 412-421.
16-Esra B, Pinar Y, Guren A, Ahmet A. Lipid peroxidation levels and total oxidant/antioxidant status in serum and saliva from patients with chronic and aggressive periodontitis. J of Periodontology 2014; 85(10); 1432-1441.
17-Daniela M, Alexandra T, Bogdan C, Brandusa M. Salivary biomarkers: relationship between oxidative stress and alveolar boneloss in chronic periodontitis. Acta Odont Scandinavica 2014; 72(1): 42-47.
Jundishapur Scientific Medical Journal
Volume 17, Issue 3 - Serial Number 114
September and October 2018
Pages 277-283

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History

  • Receive Date: 05 May 2018
  • Revise Date: 17 August 2018
  • Accept Date: 20 August 2018

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