Evaluation of Serum Selenium Level in Hospitalized Children with Acute Gastroenteritis

Document Type : Original Article

Authors

1 Department of Pediatric Pediatric Gasteroenterohepatology Pediatric Gastroentrology, Hepatology and Nutrition Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

2 Resident of Pediatric.Department of Pediatric, Mofid Children's Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

3 Assiatant professor of pediatric gastroenterohepatology Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Mofid Children's Hospital Shahid Beheshti University of Medical Sciences Tehran, Iran.

4 MSc of Neonatal Intensive Care.Department of Neonatal Health Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

5 Assiatant Professor of Pediatric Gastroenterohepatology Pediatric Gastroentrology.

Abstract

Background and Objectives: Diarrhea refers to the passage of three or more loose of watery stools per more than 15ml/kg/day in infant or >200 gr/day in older children and adolescence. Selenium (Se) is suggested, like other trace mineral and anti-oxidant enzymes, is one of the important immune factor that neutralized free oxygen radicals. Selenium deficiency leads to occurrence of bacterial infections, hair fall, loss of skin elasticity, or disease progression of some viral infections. Recent research has suggested that selenium deficiency has role in gastroenteritis therefore we designed a study for relation between serum selenium level and acute gastroenteritis.
Subjects and Methods: This is a case-control study which performed on 80 infants and children in the range of 6-36 month of age. In case group were 35 children with acute gastroenteritis and in control group were 45 healthy children. We measured serum selenium level by atomic absorption via spectrophotometer method. In control group performed once and in the case group twice during admission and recovery phase 7-10 days after treatment.
Results: The mean serum selenium level in the acute phase was 80.8±18.2 µg/L and after 7-10 days in recovery phase was 105.6±18.4 µg/L. Mean serum selenium in control group was 94.5±15.3 µg/L. Serum selenium level decreased significantly in severe dehydration than mild and moderate dehydration (P<0.001). There was no relationship between selenium level with age, weight, sex, breastfeeding, socioeconomic and underlying disease.
Conclusion: The results of this study indicate that decrease selenium level in acute phase of gastroenteritis compared to control group and significantly lower than in recovery phase. We suggest during treatment of gastroenteritis, attention to selenium deficiency need to be made.
 

Keywords

References

1-Bryce J, Boschi-Pinto C, Shibuya K, et al. WHO estimates of the causes of death in children. Lancet 2005; 365:1147.
2-Jozanov-Stankov O, Demajo M, Djujic I, Mandic M. Selenium intake as a modulator of responsiveness to oxidative stress. J Environ PatholToxicolOncol. 1998; 17:251–7.
3-King CK, Glass R, Bresee JS, et al. Managing acute gastroenteritis among children: oral rehydration, maintenance, and nutritional therapy. MMWR Recomm Rep 2003; 52:1.
4-Finkelstein JA, Schwartz JS, Torrey S, Fleisher GR. Common clinical features as predictors of bacterial diarrhea in infants. Am J Emerg Med 1989; 7:469.
5-Denno DM, Shaikh N, Stapp JR, et al. Diarrhea etiology in a pediatric emergency department: a case control study. Clin Infect Dis 2012; 55:897.
6-Turck D, Bernet JP, Marx J, et al. Incidence and risk factors of oral antibiotic-associated diarrhea in an outpatient pediatric population. J PediatrGastroenterolNutr 2003; 37:22.
7-Surawicz CM. Antibiotic-associated diarrhea in children: how many dirty diapers? J PediatrGastroenterolNutr 2003; 37:2.
8-Hemming M, Räsänen S, Huhti L, Paloniemi M, Salminen M, Vesikari T. Major reduction of rotavirus, but not norovirus, gastroenteritis in children seen in hospital after the introduction of RotaTeq vaccine into the National Immunization Programme in Finland.Eur J Pediatr. 2013 Jun; 172(6):739-46.
9-Subekti D, Lesmana M, Tjaniadi P, et al. Incidence of Norwalk-like viruses, rotavirus and adenovirus infection in patients with acute gastroenteritis in Jakarta, Indonesia. FEMS Immunol Med Microbiol 2002; 33:27.
10-Oh DY, Gaedicke G, Schreier E. Viral agents of acute gastroenteritis in German children: prevalence and molecular diversity. J Med Virol 2003; 71:82.
11-Staat MA, Azimi PH, Berke T, et al. Clinical presentations of rotavirus infection among hospitalized children. Pediatr Infect Dis J 2002; 21:221.
12-Doan LT, Okitsu S, Nishio O, et al. Epidemiological features of rotavirus infection among hospitalized children with gastroenteristis in Ho Chi Minh City, Vietnam. J Med Virol 2003; 69:588.
13-Uhnoo I, Olding-Stenkvist E, Kreuger A. Clinical features of acute gastroenteritis associated with rotavirus, enteric adenoviruses, and bacteria. Arch Dis Child 1986; 61:732.
14-Ho MS, Glass RI, Pinsky PF, et al. Diarrheal deaths in American children. Are they preventable? JAMA 1988; 260:3281.
15-Schwartz K, Foltz CM. Selenium as an integral part of factor 3 against dietary necrotic liver degeneration. J Am ChemSoc 1957; 79:3293.
16-Rayman MP. Selenium and human health. Lancet 2012; 379:1256.
17-Levander OA, Burk RF. Selenium. In: Present knowledge in nutrition, Ziegler EE, Filer LJ Jr (Eds), ILSI Press, Washington, DC 1996: 320.
18-Subcommittee on the Tenth Edition of the RDAs. Selenium. In: Recommended dietary allowances, 10th, National Academy Press, Washington, DC 1989:.217.
19-Thomson C, Robinson M. Selenium. In: Encyclopedia of food science, food technology, and nutrition, Macrae R, Robinson RK, Sadler MJ (Eds), Academic Press, London 1993: 4014.
20-Holben DH, Smith AM. The diverse role of selenium within selenoproteins: a review. J Am Diet Assoc 1999; 99:836.
21-Finley JW, Penland JG. Adequacy or deprivation of dietary selenium in healthy men: Clinical and psychologica findings. J Trace Elem Exp Med 1998; 11:11.
22-Observations on effect of sodium selenite in prevention of Keshan disease. Chin Med J (Engl) 1979; 92:471.
23-vanRij AM, Thomson CD, McKenzie JM, Robinson MF. Selenium deficiency in total parenteral nutrition. Am J ClinNutr 1979; 32:2076.
24-Look MP, Rockstroh JK, Rao GS, et al. Serum selenium versus lymphocyte subsets and markers of disease progression and inflammatory response in human immunodeficiency virus-1 infection. Biol Trace Elem Res 1997; 56:31.
25-Mazokopakis EE, Papadakis JA, Papadomanolaki MG, et al. Effects of 12 months treatment with L-selenomethionine on serum anti-TPO Levels in Patients with Hashimoto's thyroiditis. Thyroid 2007; 17:609.
26-Vogt TM, Ziegler RG, Patterson BH, Graubard BI. Racial differences in serum selenium concentration: analysis of US population data from the Third National Health and Nutrition Examination Survey. Am J Epidemiol 2007; 166:280.
27-Nève J. Selenium as a risk factor for cardiovascular diseases. J Cardiovasc Risk 1996; 3:42.
28-Yang GQ, Wang SZ, Zhou RH, Sun SZ. Endemic selenium intoxication of humans in China. Am J ClinNutr 1983; 37:872.
29-Centers for Disease Control (CDC). Selenium intoxication--New York. MMWR Morb Mortal Wkly Rep 1984; 33:157.
30-Olmez A, Yalçin S, Yurdakök K, Coşkun T. Serum selenium levels in acute gastroenteritis of possible viral origin. J Trop Pediatr. 2004 Apr;50(2):78-81.
31-Sempértegui F, Estrella B, Vallejo W, Tapia L, Herrera D, Moscoso F, Cerón G, Griffiths JK, Hamer DH. Selenium serum concentrations in malnourished Ecuadorian children: a case-control study. Int J VitamNutr Res. 2003 May; 73(3):181-6.
32-Hincal F, Başaran N, Yetgin S, Gökmen O. Selenium status in Turkey. II. Serum selenium concentration in healthy residents of different ages in Ankara. J Trace Elem Electrolytes Health Dis. 1994 Mar;8(1):9-12.
33-Kim YJ1, Galindev O, Sei JH, Bae SM, Im H, Wen L, Seo YR, Ahn WS. Serum selenium level in healthy Koreans. Biol Trace Elem Res. 2009 Nov;131(2):103-9.
34-NouriaDennouni-Medjati&YahiaHarek& Attar Tarik&LarabiLahcene. Whole Blood Selenium Levels in Healthy Adults from the West of Algeria. Biol Trace Elem Res2012; 147:44–48.
35-Safaralizadeh R, Kardar GA, Pourpak Z, Moin M, Zare A, Teimourian S. Serum concentration of selenium in healthy individuals living in Tehran. Biofactors. 2007;31(2):127-31.
36-Pourpak Z, Ranjbar A, Farhoodi A, Movahedi M, Koohkan A. Oral Selenium In The Treatment Of Refractory Severe Atopic Dermatitis: Report Of 4 Cases.
37-Esalatmanesh K, Jamshidi AR, Shahram F, Davachi F, Soleimani Z, Movahedi S. Assessment of correlation of serum selenium level and Behcet disease. KAUMS Journal (FEYZ). 2008 Apr 15;12(1):39-43.
38-Kharrazi H, Heidari R, Kiani A, Sahebjamie F. The Study of Serum Selenium in Myocardial Infarction Patients in Kermanshah (2002). Scientific Journal of Hamadan University of Medical Sciences.2005 Jan 1;12(2):10-6.
39-Davaryari N, Razavi Panah R, Homayoon Mehr S, Oskouiyan H, Mohajeri M, Ghomian N, Ghasemi SM. A Comparison of Serum Level of Selenium in Women with Preeclampsia and Normal Pregnant Women. medical journal of mashhad university of medical sciences. 2011;54(2):80-5.
Jundishapur Scientific Medical Journal
Volume 17, Issue 3 - Serial Number 114
September and October 2018
Pages 235-243

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History

  • Receive Date: 04 August 2018
  • Revise Date: 05 September 2018
  • Accept Date: 08 September 2018

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