A Case Report of Pemphigus Vulgaris with Clinically Presentation Similar to Chicken Pox

Document Type : Original Article


Dermatology Department, School of Medicine, Ahwaz Jundishapur University of Medical Sciences, Ahwaz, Iran.


Pemphigus vulgaris is a potentially fatal autoimmune disease that appears with diffuse and large blisters all over the body and if not treated, most patients will die within five years. The disease usually occurs in the fifth or sixth decade of life. In this case-report, we present a seventeen-year old girl  with pemphigus, but clinical presentation  were quite similar to chickenpox. Because of the extreme rarity of cases in which pemphigus vulgaris presents itself as chickenpox and the clinical differentiation and treatment interventions between them is very important (corticosteroid versus antiviral and supportive care respectively), as a result biopsy is recommended in unusual  cases of chickenpox.


1-Amagai M, Pemphigus, Bolognia J, Jorizzo j, Schaffer j. Dermatology. 3th ed. USA: ELSEVIER sunders; 2012, P. 416-473.
2-Jesse P. Houghton, lonosi-lrimie M, Stacey B, Trooskin, "et al". Unusual Presentation of pemphigus vulgaris. Gastroenterol Hepatol (N Y)  2008 Jan; 4(1): 68-70.
3- javali M A, Heena Z. Pemphigus vulgaris presenting as gingival involvement. Indian Dermatol Online J 2012 ; 3(3): 202-4.
4- Adriano AR, Gomes Neto A, Hamester G A, Nunes D H,  Di Giunta G. Pemphigus vegetans induced by use of enalapril. An Bras Dermatol 2011 Nov-Dec; 86(6): 1197-200.
5-HH Tan,YK Tay. An unusual case of pemphigus vulgaris presenting as bilateral foot ulcers. Clin Eep Dermatol 2000; 25: 224-6.
6- Milgraum SS, Kanzler MH, Waldinger TP, Wong RC. an unusual presentation of pemphigus vulgaris. Arch Dermatol 1985; 121(10): 1328-9.
7- Daneshpazhooh M, Davachi C, Ramezani A, Moinedin F, Rezaei Hemami M.  LAbortive aphtous-like oral lesions :an underreported initial presentation of pemphigus vulgaris. J Eur Acad Dermatol Venereol 2009; 23:157-9.
8-Erlich KS. Varicella-Zoster Virus and HIV, 2011. Available at: URL: http//hivinsite. ucsf.edu/InSite?page=kb-05-03-01. Accesed Oct 17, 2014.
9-Hong wu, hea ther A. Brandling – Bennet, and Tere nce j. harris. Non infactious vesiculobullous and vesicaulopustular Disease. Elder E, Elenitsas Rosaliem Johnson Berhttl, Murphy Georg F,  and Xuxiawei. Lever’s histopathology of the skin. 10th  ed. USA: 2009:247.
 10-Goon AT, Tay YK, Tan SH. Pemphigus vulgaris following  varicella infection. Clin Exp Dermatol 2001; 26: 661-3.