Assessment of Genetic Variation of - and -Thalassemia Disorder among Marriage Applicants in Abadan and Khorramshahr

Document Type : Original Article

Authors

1 Department of Health, School of Medical Sciences, Abadan.

2 Research Center of Thalassemia& Hemoglobinopathy, Ahvaz Jondishapur University of Medical Sciences Ahvaz, Iran

3 Fisheries Office of Khuzestan.

4 Department of Medical University of Jondishapur University of Medical Sciences Ahvaz, Iran.

Abstract

Background and Objective: Thalassemia is a hereditary anemia. Two main types are classified as α-and β -Thalassemia..More than 95 % of known cases of α- Thalassemia is due to the deletion of one or two genes, α- globin chains of chromosomes (2).
Subject and Methods: In this cross-sectional study, 17,581persons, blood parameters were measured. subjects having MCV <80, MCH <27, HBA2 ≥ 3/5 of the carriers β- Thalassemia gene were considered, from whom 50 persons were andomly selected and genetic laboratory to identify the mutation was referred(4).
Results: From 17,581, 995 applicant, equivalent (5.6%) of carriers of β-thalassemia trait with frequency variation in mutatiomn gene in IVSІІ-1(25%), IVSІ-110 (16%), CD 36/37(15%), IVSІ-S(8%), CD5(9%), IVSІ-6(7%), IVSІ-1(5%), CD39(5%).While the genotype frequencies for α-thalassemia mutations were αα/med- -with 11percent and -α3.7 /-α3.7 , αα/-α4.2with10% and 7% respectively Eighty of these cases were carrier of deletion mutation genotype αα/αpoly A2α  and 9% α-thalassemia mutation genotype were non-deletion (4).
Conclusions: This study showed that the prevalence of thalassemia minor in Abadan and Khorramshahr 5.6 percent is. The most common mutation was IVSII-I type. The frequency of α- thalassemia is 6.65 percent .The α-gene carriers and the most alpha chain gene disorders group αα /-α3.7with50% frequency(6).
 

Keywords

References

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Jundishapur Scientific Medical Journal
Volume 13, Issue 5 - Serial Number 92
November and December 2017
Pages 589-597

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History

  • Receive Date: 10 March 2014
  • Revise Date: 14 July 2014
  • Accept Date: 03 August 2014

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