The Diagnostic Value Non Invasive Tests in Predicting Liver Fibrosis

Document Type : Original Article

Authors

1 Research Institute for Infectious Diseases of Digestive System, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

2 Department of Paramedicine, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

Background and Objectives: Liver biopsy is the gold standard for assessing liver fibrosis.Scoring systems such as BARD and BAAT has been studied in the detection of liver fibrosis. The objective of this is study was to determine the diagnostic value of BARD and BAAT Scoring systems in predicting liver fibrosis.
Subjects and Methods: In this cross-sectional study, the study group was selected among patients whit breast cancer. Those with chronic liver disease were excluded from the study. Finally 60 female patients with breast cancer included and undergone liver elastography. Elastography results were compared with BARD and BAAT.
Results: The clinical data of the patients with liver stiffness degrees F0-F2 and F3-F4 based on transient elastography were compared. The rate of  BARD score 3-4 concordance with the F3-4  degrees of liver stiffness in transient elastography had a  sensitivity, specificity, positive and negative predictive value of 84.6 %, 72.3 %,45.8 %  and 94.4 % respectively with accuracy 75 % and odds ratio of 14.38 (95% CI: 2.8-73.9). The corresponding values for BAAT score were 91.5 % ,  93.6 % , 72.7 % and 89.8 % with an accuracy of 86.66 %  and odds ratio of 23.46  (95% CI:4.56 - 118 ).
Conclusions: In this study, there was a significant association between BAAT and BARD scores with advanced degrees of liver stiffness. In cases where liver elastography or liver biopsy is unavailability or patients are reluctant, the BAAT and BARD scores are useful for determining the severity of liver fibrosis.

Keywords

References

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Jundishapur Scientific Medical Journal
Volume 13, Issue 5 - Serial Number 92
November and December 2017
Pages 533-543

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History

  • Receive Date: 23 June 2014
  • Revise Date: 14 July 2014
  • Accept Date: 21 July 2014

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