Jundishapur Journal of Medical Sciences

Jundishapur Journal of Medical Sciences

Evaluation of Typical Antipsychotic Augmentation with Sertraline in Reduction of Negative Symptoms in Patients with Schizophrenia in Ahvaz Golestan Hospital

Document Type : Original Article

Authors
1 Department of Psychiatry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
2 Department of Psychiatry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Abstract
Background and Objective: The aim of this study was to evaluate the efficacy of sertraline added to typical antipsychotics for the treatment of negative symptoms of patients with schizophrenia disorder.
Subjects and Methods: This study is a randomized double blind clinical trial. Thirty patients suffering from schizophrenia disorder (DSM-IV-TR) were selected randomly and devided into two groups. Depression was ruled out by Hamilton Depression Questionnaire. A group was given sertraline (50 mg/day) and the other group received placebo . The efficacy of sertraline and placebo in reduction of social withdrawal‚ emotional withdrawal‚ blunted affect and other negative symptoms was assessed weekly with PANSS scale during 6 weeks.
Results: Sertraline did not improve social withdrawal‚ emotional withdrawal‚ blunted affect and other negative symptoms in schizophrenia patients compared with placebo.
Conclusion: Adding sertraline on typical antipsychotic treatment does not seem to improve negative symptoms in patients with schizophrenia disorder.
 
Keywords

1-Sadock BJ, Sadock VA, Ruiz P, eds. Kaplan & Sadock's comprehensive textbook of psychiatry. 9th ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins; 2009. P. 1432-556.
2-Sadock  BG, Sadock VA, eds. Kaplan & Sadock's synopsis of psychiatry: behavioral science/clinical psychiatry. 10th ed. Philadelphia: Wolter Kluwer/Lippincott, Williams & Wilkins; 2007. P. 123-6 .
3-Goff DC, Midha KK, Sarid-Segal O, Hubbard JW, Amico E. A placebo-controlled trial of fluoxetine added to neuroleptic in patients with schizophrenia. Psychopharmacology (Berl) 1995;117(4):417-23.
4-Shoja-Shafti S. [Effectiveness of citalopram alprazolam, clomipramine in amelioration of negative symptoms in schizopherenia]. J Rehabilitation 2003;3(12):42-9. [In Persian]
5-Melle I, Johannesen J, friis S, Haahr U, Joa I, Larsen TK, et al. Early detection of the first episode of schizophrenia and suicidal behavior. Am J Psychiatry 2006;163(5):800-4.
6-Gelder MG, Harrison PJ, Cowen Ph. Shorter oxford textbook of Psychiatry. 5th ed. Oxford: Oxford University Press; 2006. P. 267-306.
7-Silver H, Aharon N, Kaplan A. Add-on Fluvoxamine improves primary negative symptoms evidence for specificity from response analysis of individual symptoms. Schizophr  Bull 2003;29(3):541-6.
8-Erhart SM, Marder SR, Carpenter WT. Treatment of Schizophrenia Negative Symptoms: Future Prospects. Schizophr Bull 2006;32(2):234-7.
9-Shoja-Shafti S, Bakhtiari M. [Evaluation of prevalance of negetive symptoms in1% inpatients Schizophrenic ]. J Rehabilitation 2003;3(10):38-47. [In Persian]
10-Siris SG, Mason SE, Bermanzohn  PC, Alvir JM, McCorry TA. Adjunctive imipramine maintenance in post-psychotic depression/negative symptoms. Psychopharmacol Bull 1990;26(1):91-4.
11-Raedler TJ, Jahn H, Arlt J, Kiefer F, Schick M, Naber D, et al. Adjunctive use of reboxetine  in  schizophrenia. Eur Psychiatry 2004;19(6):366-9.
12-Salokangas RK, Saarijarvi S, Taiminen T, Kallioniemi H, Lehto H, Niemi H, et al. Citalopram as an adjuvant in chronic schizophrenia: a double-blind placebo-controlled study. Acta Psychiatr Scand 1996;94(3):175-80.
13-Taiminen TJ1, Syvälahti E, Saarijärvi S, Niemi H, Lehto H, Ahola V, et al. Citalopram as an adjuvant in   schizophrenia: Furthur evidence for a serotonergic dimension in schizophrenia. Int Clin Psychopharmacol1997;12(1):31-5.
14-Thakore JH, Berti C, Dinan TG. An open trial of adjunctive sertraline in the treatment of chronic schizophrenia. Acta Pychiatr Scand 1996;94(3):194-7.
15-Lee MS, Kim YK, Lee SK, Suh KY. A double-blind study of adjunctive sertraline in haloperidol-stabilized patients with chronic schizophrenia. J Clin Psychopharmacol 1998;18(5):399-403 .
16-Sardarpur Sh, Arbabi M. Efficacy of naltroxan in treatment of  schizophrenia.A double- blind, placebo-controlled clinical trial. Iran Clin Psychiatr J 2006;12(1):49-54.[In Persian]
17-Phayezi B. Efficacy of selgilin in schizophrenia negative symptoms.A double- blind study. Iran Clin Psychiatr 2008;14(2):131-139. [In Persian]
18-Maleki M, Javidi Z, Kiafar B, Saadatian V, Saremi AK. Depression in vitiligo patients. Q J Fundamentals Mental Health 2005;7(25-26):5-11. [In Persian]
19-Sepehri AA, Potvin S, Elie R, Stip E. Selective serotonin reuptake inhibitor (SSRI) add-on therapy for the negative symptoms of schizophrenia: a meta- analysis. J Clin Psychiatr 2007;68(4):604-10.
20-Takahashi H, Sugita T, Higuchi H, Shimizu T. Fluvoxamine augmentation in risperidone-resistant schizophrenia: an open trial. Hum Psychopharmacol 2002;17(2):95-8.
21-Silver H, Shmugliakov N. Augmentation with fluvoxamine but not maprotiline improves negative  symptoms in treated schizophrenia: evidence for a specific serotonergic effect from a double-blind study. J Clin Psychopharmacol 1998;18(3):208-11.
22-Lee MS, Han CS, You YW, Kim SH. Co-adminstration of sertraline and haloperidol. Psychiatry Clin Neurosci 1998;52:S193-8.
23-Singh SP, Singh V, Kar N, Chan K. Efficacy of antidepressants in treating the negative symptoms of chronic schizophrenia: meta- analysis. Br J Psychiatry 2010;197(3):174-9.
24-Erhart SM, Marder SR, Carpenter WT. Treatment of schizophrenia negative symptoms: Future prospects. Schizophr Bull 2006;32(2):234-7.
25-Silver H. Selective serotonin reuptake inhibitor augmentation in the treatment  of  negative symptoms of schizophrenia. Int Clin Psychopharmacol 2003;18(6):305-313. 
26-Nazari Nasab M, Khajeddin N, Shanesaz AA, Pezeshki A. [Evaluation of typical antipsychotic augmentation  with citalopram in reduction of negative symptoms in inpatient  schizophrenia in Ahvaz  Golestan Hospital]. Jundishapur Sci Med J 2012;11(4):439-48. [In Persian]
Volume 13, Issue 3 - Serial Number 90
September and October 2014
Pages 335-345

  • Receive Date 22 April 2013
  • Revise Date 14 January 2014
  • Accept Date 01 March 2014