Evaluation of Typical Antipsychotic Augmentation with Sertraline in Reduction of Negative Symptoms in Patients with Schizophrenia in Ahvaz Golestan Hospital

Document Type : Original Article

Authors

1 Department of Psychiatry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

2 Department of Psychiatry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Abstract

Background and Objective: The aim of this study was to evaluate the efficacy of sertraline added to typical antipsychotics for the treatment of negative symptoms of patients with schizophrenia disorder.
Subjects and Methods: This study is a randomized double blind clinical trial. Thirty patients suffering from schizophrenia disorder (DSM-IV-TR) were selected randomly and devided into two groups. Depression was ruled out by Hamilton Depression Questionnaire. A group was given sertraline (50 mg/day) and the other group received placebo . The efficacy of sertraline and placebo in reduction of social withdrawal‚ emotional withdrawal‚ blunted affect and other negative symptoms was assessed weekly with PANSS scale during 6 weeks.
Results: Sertraline did not improve social withdrawal‚ emotional withdrawal‚ blunted affect and other negative symptoms in schizophrenia patients compared with placebo.
Conclusion: Adding sertraline on typical antipsychotic treatment does not seem to improve negative symptoms in patients with schizophrenia disorder.
 

Keywords

References

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Jundishapur Scientific Medical Journal
Volume 13, Issue 3 - Serial Number 90
September and October 2014
Pages 335-345

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History

  • Receive Date: 22 April 2013
  • Revise Date: 14 January 2014
  • Accept Date: 01 March 2014

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