The Effect of Twelve Weeks Combined Training (Aerobic + Resistance) on the Irisine and Insulin Resistance in Obese Sedentary Women


1 MS in Exercise Physiology. Abadan Azad University, Abadan, Iran.

2 of Physical Education and Sport Sciences. Department of Physical Education and Sport Sciences, Urmia University of Technology, Band Road, Urmia, West Azerbaijan, Iran.


Background and Objective: Irisine can lead to weight loss, improvement of insulin sensitivity and glucose tolerance through changes in the phenotype of white fat cells into brown fat cells and increase in thermogenesis. The aim of this study, therefore, was to investigate the effect of 12 weeks combined training on the irisine and insulin resistance index among sedentary obese women.
Subjects and Methods:In this quasi-experimental study 32 obese women (48± 14 years) were selected and divided into two group of control and experimental (n=16 each). Twelve weeks training, 3 sessions per week included continuous aerobic exercises (20 min, 65-75% of HRR), and circular resistance training (10 stations with 70%  1RM). The aerobic training included 20 min duration with 65-75% HRR per session and the resistance training program included 10 stationary exercise as did circular with 70% 1RM. Blood samples were collected 24 hr before start the training and 48 hr after the last training session. In the present study the analysis of covariance was used (P≤0.05).
Results: The results showed a significant increase in levels of irisine (P=<0.0001) and a significant decrease in insulin resistance (P=<0.0001), weight (P=0.013), Body Mass Index (P=0.031) and fat mass (P=0.045).
Conclusion: The results of this study showed that combining exercise (aerobic + resistive) in addition to weight loss and decrease body fat mass it leads to improvement in insulin function and is therefore a sueful method for improving body composition and promoting women's health.


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