The Evaluation of the Relationship between Plasma Levels of Factor VIII with Bleeding Symptoms in Hemophilia a Carriers Referring to Shafa Hospital of Ahvaz, Iran

Document Type : Original Article


1 Professor of Pediatrics, Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz,

2 Medical Student, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


Background and Objective: Hemophilia is an X linked bleeding disorder due to the decreased level of coagulation factors. In this disease bleeding in different parts of the body manifested as bruising and bleeding in gastrointestinal, musculoskeletal, genitourinary and other organs. The aim of this study was to investigate the role of factor VIII as a cause factor for bleeding among hemophilia A carries.
Subjects and Methods: This study was based on a preliminary interview with carriers of hemophilia A to gather information on the occurrence and symptoms of the bleeding experienced along with family records. Then the serum level of factor VIII was measured. A total of 70 patients were selected for the study based on sample size. The data obtained were analyzed using SPSS software.
Results: Lack of factor VIII on its own can increase the risk of bleeding in patients with hemophilia A carriers. Based on the data analysis, factor VIII serum level less than and in the range of 40-45 carries an increased risk of bleeding. Bleeding from different sits such as gums, mouth, and menorrhagia alone are not dependent on the level of factor VIII, however, it is level is contributing factor in bleeding tendency
Discussion: Due to the increased risk of bleeding in patients with lower levels of factor VIII, it is necessary to fully scrutinize these patients by assessing serum level of factor VIII and in terms of the development of bleeding. In addition, in order to prevent further complications, increase in awareness among these patients of their condition can be helpful.
Key words: Hemophilia A, Bleeding, Factor VIII.


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