Comparison of 12 Weeks Aerobic with Resistance Exercise Training on Serum Levels of Resistin and Glycemic Indices in Obese Postmenopausal Women with Type 2 Diabetes (Comparison of Two Exercise Protocols)

Document Type : Original Article


Departmet of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Urmia University, Iran.


Background and Objective:  Resistin, as an adipokine is associated with obesity and insulin resistance, but the effects of different exercise trainings on the levels of this hormone is unknown. The aim of the present study was to compare the effects of aerobic with resistance exercise training on change in serum resistin level in obese postmenopausal women with type 2 diabetes.
Subjects and Methods: In a quasi-experimental study 40 women with type 2 diabetes were selected as available and by purposive sampling and were randomly assigned into 3 groups of aerobic training (n = 14), resistance training (n = 13) and control (n = 13) groups. Aerobic group accomplished (12 weeks of aerobic training, 3 times a week, for 20-50 minutes at 50-70% of maximum heart rate), the resistance group received (resistance training 3 times a week in 3 sets of 10 repetitions with 40-60% of a repetition maximum). The control group was sedentary during the same period. Blood samples were collected for measurement of the levels of resistin, insulin, HbA1c and glucose. Insulin resistance was calculated with HOMA-IR equation.
Results: Resistin serum level was increased in both exercise training groups (P<0.05), anthropometric measurements decreased in aerobic group only (P<0.05), while insulin resistance was decreased in resistance group (P<0.05). Glycated hemoglobin and glucose decreased in both training groups (P ˂0.05).
Conclusion: It seems that during12 weeks, both types of aerobic and resistance exercise training have beneficial effects, through different mechanisms, in patients with type 2 diabetes.


1-Fox CS, Pencina MJ, Meigs JB, Vasan RS, Levitzky YS, D'Agostino RB Sr. Trends in the incidence of type 2 diabetes mellitus from the 1970s to the 1990s: the Framingham Heart Study. Circulation 2006;113(25):2914–18.
2-Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR,Wright CM, et al. The hormone resistin links obesity to diabetes. Nature 2001;409(6818):307–12.
3- Shehab AK. Aerobic versus resistance exercise training in modulation of insulin resistance, adipocytokines and inflammatory cytokine levels in obese type 2 diabetic patients. Journal of Advanced Research 2011; 2(2): 179–83.
4-Stejskal D, Adamovska S, Bartek J, Jurakova R, Proskova J. Resistin – concentrations in persons with type 2 diabetes mellitus and in individuals with acute inflammatory disease. Biomed Pap Med Fac Univ palacky Olomouc Czech Repub 2003;147(1):63-9.
5-Perseghin G, Burska A, Lattuada G, Alberti  G, Costantino F, Ragogna F, et al. Increased serum resistin in elite endurance athletes with high insulin sensitivity. Diabetologia 2006;49(8):1893-900.
6-Kim KH, Lee k, Moon YS, Sul HS. A cysteine – rich adipose tissue – specific secretory factor inhibits adipocyte differentiation. J Biol Chem 2001;276(14):11252 –6.
7-Kopff B, Jegier A. [Adipokines: adiponectin, leptin, resistin and coronary heart disease risk]. Przegl lek 2005;62 Suppl 3:69-72. [In Polish]
8-Hoefle G, Saely CH, Risch L, Koch L, Schmid F, Roin P, et al. Relationship between the adipose-tissue hormone resistin and coronary artery disease. Clin Chim Acta 2007;386(1-2):1-6.
9-Kadoglou NP, Perrea D, Iliadis F, Angelopoulou N, Liapis C, Alevizos M. Exercise reduces resistin and inflammatory cytokines in patients with type 2 diabetes. Diabetes care 2007;3(30):719-21.
10-Jorge ML, de Oliveira VN, Resende N, Paraiso LF, Calixto A, Diniz AL, et al. The effects of aerobic, resistance and combined exercise on metabolic control, inflammatory markers, adipocytokines and muscle insulin signaling in patients with type 2 diabetes mellitus. Metabolism 2011;60(9):1244-52.
11-Bacchi E, Negari C, Zanelin ME, Milanese C, Faccioli N, Trombetta M, et al. Metabolic effects of aerobic training and resistance training in type 2 diabetic subjects: a randomized controlled trial (the RAED2 study). Diabetes care 2012; 35(4):676-82.
12- Dixon JB. The effects of obesity on health outcomes. Moll Cell Endocrinol 2010; 316(2):104–8.
13-Yavari A, Najafipoor E, Aliasgarzadeh A, Niafar M, Mobasseri M. Effects of aerobic exercise, resistance training on Glysaemic control and cardiovascular risk factors in patients with type 2 diabetes. Biology of Sport 2012; 29 (2):135- 43.
14-Giannopoulou I, Fernhall B, Carhart R, Weinstock R, Baynard T, Figueroa A, et al. Effects of diet and/ or exercise on the adipocytokine and in flammatory cytokine levels of postmenopausal women with type 2 diabetes. Metabolism 2005;54:866 –75.
15-Jones TE, Basilio JL, Brophy PM, McCammon MR, Hickner RC. Long–term exercise training in overweight adolescents improves plasma Peptide YY and resistin. Obesity 2009;17(6):1189- 95.
16- Prestes J, Shiguemoto G, Botero JP, Frollini A, Dias R, Leite R, et al. Effects of resistance training on resistin, leptin, cytokines, and muscle force in elderly post–menopausal women. J Sports Sci 2009;27(14):1607-15.
17-Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 1998;15(7):539-53.
18-Thomas S, Reading J, Shephard RJ. Revision of the Physical Activity Readiness Questionnaire (PAR – Q). Can J Sport Sci 1992;17(4):338-45.
 19-Jackson AS, Pollock ML, Ward A. Generalized equations for predicting body density of women. Med Sci Sports Exerc 1980;12(3):175- 82.
20- Robergs RA, Landwehr R. The surprising history of the ‘HR max = 220 – age’ equation. Official Journal of       American Society of Exercise Physiologists (ASEP)  2002; 5(2):1-16.
21-Nikander R, Sievanen H, Ojala K, Oivanen T, Kellokumpu-Lehitnen PL, Saarto T. Effect of a vigorous aerobic regimen on physical performance in breast cancer patients – a randomized controlled pilot trial. Acta Oncol 2007;46(2):181-6.
22-Maud PJ, Foster C. Physiological assessment of human fitness. 2nd ed. Champaign: Human Kinetics; 2006. P. 119-50.
23-Kraemer WJ, Ratamess NA. Fundumentals of resistance training: progression and exercise prescription. Med Sci Sports Exerc 2004;36(4):674-88.
24-Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta–cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28(7):412 –9.
25-Marwick TH, Hordem MD, Miller T, Chyun DA, Bertoni AG, Blumenthal LS, et al. Exercise training for type 2 diabetes mellitus: impact on cardiovascular risk: a scientific statement from the American Heart Association. Circulation 2009;119(25):3244-62.
26-Boule NG, Haddad E, Kenny GP, Wells GA, Sigal RJ. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta- analysis of controlled clinical trails. JAMA 2001;286(10):1218-27.
27-Goldhaber- Fiebert JD, Goldhaber- Fiebert SN, Tristan ML, Nathan DM. Randomized controlled community-based nutrition and exercise intervention improves glycemic and cardiovascular risk factors in type 2 diabetic patients in rural Costa Rica. Diabetes Care 2003;26(1):24-9.
28-Reid RD, Tulloch HE, Sigal RJ, Kenny GP, Fortier M, McDonnell L, et al. Effects of aerobic exercise, resistance exercise or both, on patient–reported health status and well-being in type 2 diabetes mellitus: a randomized trial. Diabetologia 2010;53(4):632-40.
29-Sigal RJ, Kenny GP, Boule NG, Wells GA, Prud'homme D, Fortier M, et al. Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial. Ann Intern Med 2007;147(6):357-69
30-Arora E, Shenoy S, Sandhu JS. Effects of resistance training on metabolic profile of adults with type 2 diabetes. Indian J Med Res 2009;129(5):515-9.
31- Shenoy S, Arora E, Jaspal S. Effects of progressive resistance training and aerobic exercise on type 2 diabetics  in Indian Population. Int J Diabetes Metab 2009;17:27-30.
32-Ryan AS, Pratley RE , Elahi D, Goldberg AP. Changes in plasma leptin and insulin action with resistive training in postmenopausal women. Int J Obes Rlat Metab Disord 2000;24(1):27-32.
33-Miller JP, Pratley RE, Elahi D, Goldberg AP, Gordon P, Rubin M, Treuth MS, et al. Strength training increases insulin action in healthy 50- to 65-yr- old men. J Appl Physiol 1994;77(3):1122-7.
34-Zachwieja JJ, Toffolo G, Cobelli C, Bier DM, Yarasheski KE. Resistance exercise and growth hormone administration in older men: effects of insulin sensitivity and secretion during a stable–lable intravenous glucose tolerance test. Metabolism 1996;45(2):254-60.
35- Qi Q, Wang J, Li H, Yu Z, Ye X, Hu FB, et al. Associations of resistin with inflammatory and fibrinolytic markers, insulin resistance, and metabolic syndrome in middle–aged and older Chinese. Eur J Endocrinol 2008;159(5):585- 93.
36-Azuma K, Katsukawa F, Oguchi S, Murata M, Yamazaki H, Shimada A, et al. Correlation between serum resistin level and adiposity in obese individuals. Obes Res 2003;11(8):997-1001.