The Effect of Aerobic Training and Consumption of Omega-3 on Male Pulmonary Function with Type II Diabetes

Document Type : Original Article


1 MSc in Exercise Physiology.Department of Physical Education and Sports Science, Bu-Ali Sina University, Hamedan, Iran.

2 Endocrinologist and Metabolism Specialist.Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

3 MSc in Exercise Physiology.Department of Physical Education and Sports Science, Shahid Rajaeae Teacher Training University, Tehran, Iran.

4 MSc in Exercise Physiology. Dezful University of Medical Sciences, Dezful, Iran


Background and Objective:  One of the complications of diabetes is respiratory problems and reduced lung function in these patient. There for the aim of this study was to investigate the effect of aerobic exercise and consumption of omega-3 on male pulmonary function with type II diabetes.
Subjects and Methods:  In the present quasi-experimental study, 40 male with type II diabetes with an average 43.5 ± 4.9 y old were selected by purposive sampling method and randomly divided into 4 groups: exercise + placebo, exercise + omega-3, omega-3 and placebo. Training for eight weeks, three times a week and each session includes 45-60 min of aerobic exercise with 50-70% of heart rate reserve. 1000 mg Omega-3 capsules were consumed daily. For statistical analysis t-test and ANOVA were used (P ≤ 0.05).
Results: After regular training for 8 weeks, a significant increase was observed in FVC, FEV1 and VO2max in two groups: exercise + placebo and exercise + omega-3 compared to placebo. VO2max levels significantly increased in exercise + placebo and exercise + omega-3 compared to omega-3. Also significant increase in FVC in exercise + placebo compare to omega-3 group (P < 0.05). However, no significant difference was found between the two groups of exercise + omega-3 and exercise + placebo groups (P > 0.05).
Conclusion: The results showed that the aerobic training were more effective on pulmonary and breathing function than the consumption of omega-3 alone. In addition, consumption of omega-3 and combination aerobic training of FVC were more effective than the consumption of omega-3 alone.


1-Chatterjee S, Khunti K, Davies MJ. Type 2 diabetes. The Lancet. 2017;DOI:
2-Oluwaseyi O, Sunday A, Abraham O, Olajide O. Effect of Progressive Aerobic and Resistance Exercises on the Pulmonary Functions of Individuals with type 2 diabetes in Nigeria. International Journal of Endocrinology and Metabolism. 2012;10(1):411-7.
3-Davis WA, Knuiman M, Kendall P, Grange V, Davis TM. Glycemic exposure is associated with reduced pulmonary function in type 2 diabetes. Diabetes Care. 2004;27(3):752-7.
4-Acharya PR, D’Souza M, Anand R, Kotian SM. Pulmonary Function in Type 2 Diabetes Mellitus: Correlation with Body Mass Index and Glycemic Control. International Journal of Scientific Study. 2016;3(11):18-23.
5-Andersen H, Nielsen S, Mogensen CE, Jakobsen J. Muscle strength in type 2 diabetes. Diabetes. 2004;53(6):1543-8.
6-Kabitz H-J, Sonntag F, Walker D, Schwoerer A, Walterspacher S, Kaufmann S, et al. Diabetic polyneuropathy is associated with respiratory muscle impairment in type 2 diabetes. Diabetologia. 2008;51(1):191-7.
7-Corrêa AP, Ribeiro JP, Balzan FM, Mundstock L, Ferlin EL, Moraes RS. Inspiratory muscle training in type 2 diabetes with inspiratory muscle weakness. Med Sci Sports Exerc. 2011;43(7):1135-41.
8-Malek F, Malek M, Tosi J, Soltabi S, Hashemi H. Comparison of Pulmonary Function in Diabetic Patients with and Without Retinopathy Compared with Control Group. Journal of Endocrinology and Metabolism. 2010;11(2):143-50.
9-Aparna A. Pulmonary function tests in type 2 diabetics and non-diabetic people—a comparative study. J Clin Diagn Res. 2013;7:1606-8.
10-Yu D, Chen T, Qin R, Cai Y, Jiang Z, Zhao Z, et al. Association between lung capacity and abnormal glucose metabolism: findings from China and Australia. Clinical endocrinology. 2016;85(1):37-45.
11-Klein O, Krishnan J, Glick S, Smith L. Systematic review of the association between lung function and Type 2 diabetes mellitus. Diabetic medicine. 2010;27(9):977-87.
12-Anand N, Nayyer P, Rana V, Verma S. Changes in pulmonary functions in type 2 diabetes mellitus. Indian Journal of Medical Specialities. 2017;8(1):3-6.
13-Wilms B, Ernst B, Thurnheer M, Spengler CM, Schultes B. Type 2 Diabetes is Associated with Lower Cardiorespiratory Fitness Independent of Pulmonary Function in Severe Obesity. Experimental and Clinical Endocrinology & Diabetes. 2017.1-10.
14-Ghalavand A, Shakeryan S, Nikbakht M, Mehdipour A, Monazamnezhad A, Delaramnasab M. Effects of aerobic training on cardiorespiratory factors in men with type 2 Diabetes. jurnal of diabetes nursing. 2014;2(2):8-17.
15-Afshonpour M, Ghalavand A, Rezaee R, Habibi A. The Effect of Exercise Training on Pulmonary Function in Type 2 Diabetic Men. Alborz university medical journal. 2015;4(4):255-65.
16-Ghalavand A, Shakeriyan S, Rezaee R, Hojat S, Sarshin A. The Effect of Resistance Training on Cardio Respiratory Factors in Men with Type 2 Diabetes. Alborz University Medical Journal 2015;4(1):59-67.
17-Gold DR, Luttmann-Gibson H, Litonjua AA, Friedenberg G, Gordon D, Lee I-M, et al. Baseline Chronic Obstructive Pulmonary Disease In The Lung Vitamin D And OmegA-3 TriaL. Am Thoracic Soc; 2014. p. A5996-A.
18-Ade CJ, Rosenkranz SK, Harms C. The effects of short-term fish oil supplementation on pulmonary function and airway inflammation following a high-fat meal. European journal of applied physiology. 2014;114(4):675-82.
19-Mickleborough TD, Murray RL, Ionescu AA, Lindley MR. Fish oil supplementation reduces severity of exercise-induced bronchoconstriction in elite athletes. American journal of respiratory and critical care medicine. 2003;168(10):1181-9.
20-Kidd PM. Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids. Alternative medicine review. 2007;12(3):207.
21-Driskell JA. Sports nutrition: fats and proteins: CRC Press; 2007.
22-Tartibian B, Maleki BH, Abbasi A. Omega-3 fatty acids supplementation attenuates inflammatory markers after eccentric exercise in untrained men. Clinical Journal of Sport Medicine. 2011;21(2):131-7.
23-Tartibian B, Maleki BH, Abbasi A. The effects of omega-3 supplementation on pulmonary function of young wrestlers during intensive training. Journal of Science and Medicine in Sport. 2010;13(2):281-6.
24-Nagakura T, Matsuda S, Shichijyo K, Sugimoto H, Hata K. Dietary supplementation with fish oil rich in omega-3 polyunsaturated fatty acids in children with bronchial asthma. European Respiratory Journal. 2000;16(5):861-5.
25-Mickleborough TD, Lindley MR. The Effect of Combining Fish Oil and Vitamin C on Airway Inflammation and Hyperpnea-Induced Bronchoconstriction in Asthma. J Allergy Ther. 2014;5(4):1-10.
26-Sobhani V, Hajizadeh B, Bazgir B, Kazemipour M, Shamsoddini A, Shakibaey A. Effect of 8-week omega-3 supplementation on pulmonary function during classic army ranger training. Feyz. 2014;17(6):553-60.
27-Dehghanianfard M, Ghanbarzadeh M, Habibi A. Effect of Short Term Omega-3 Supplementation on Pulmonary Function after Acute Aerobic Exercise in Athletes with Exercise-Induced Bronchospasm. The Horizon of Medical Sciences. 2017;23(1):69-75.
28-Katz DP, Manner T, Furst P, Askanazi J. The use of an intravenous fish oil emulsion enriched with omega-3 fatty acids in patients with cystic fibrosis. Nutrition. 1996;12(5):334-9.
29-Chudyk A, Petrella RJ. Effects of exercise on cardiovascular risk factors in type 2 diabetes. Diabetes care. 2011;34(5):1228-37.
30-Remuzzi G, Schieppati A, Ruggenenti P. Nephropathy in patients with type 2 diabetes. New England Journal of Medicine. 2002;346(15):1145-51.
31-Group AS, Group AES. Effects of medical therapies on retinopathy progression in type 2 diabetes. N Engl J Med. 2010;2010(363):233-44.
32-Boulton AJ, Vinik AI, Arezzo JC, Bril V, Feldman EL, Freeman R, et al. Diabetic neuropathies. Diabetes care. 2005;28(4):956-62.
33-Abolfathi F, Ranjbar R, Shakerian S, Yazdanpanah. The Effect of Eight Weeks Aerobic Interval Training on Adiponectin Serum Levels, Lipid Profile and HS-CRP in Women With Type II diabetes. 2015;17(4):316-24.
34-Womack CJ, Harris DL, Katzel LI, Hagberg JM, Bleecker ER, Goldberg AP. Weight loss, not aerobic exercise, improves pulmonary function in older obese men. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2000;55(8):M453-M7.
35-Baldi JC, Wilson GA, Wilson LC, Wilkins GT, Lamberts RR. The Type 2 Diabetic Heart: Its Role in Exercise Intolerance and the Challenge to Find Effective Exercise Interventions. Sports Medicine. 2016;46(11):1605-17.