Evaluation of the Effect of Injection of Bupivacaine in Reducing Nausea and Vomiting after Laparoscopic Cholecystectomy Surgery

Document Type : Original Article


1 Department of Anesthesiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

2 Department of Surgery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran


Background and Objectives: Nowadays, using laparoscopic surgery, including   lower risks,is becoming more common. so patients can go home early. However, nausea and vomiting after surgery because of irritation of the diaphragm and  peritoneal  stretch is very annoying.  appropriate method of treatment is necessary to reduce nausea and vomiting after laparoscopic surgery. In this study, effectiveness of intraperitoneal administration of bupivacaine  to reduce nausea and vomiting after laparoscopic cholecystectomy surgery was assessed.
Subjects and Methods: in this randomized , double blind clinical trial 50 patients were enrolled. Patients were randomly divided into two groups. In the normal saline group, 0.5 ml/kg of 0/45% normal saline and in bupivacaine group, 0/5 mg/Kg bupivacaine 0/5% was injected into the peritoneal cavity at the end of surgery. The incidences of nausea and vomiting were compared at 1, 2, 6 and 12 hrs after surgery.
Results: Both groups were compared in terms of nausea and vomiting. Nausea decreased in bupivacaine group in 1 and 2 hours after surgery(p value =0/01). but no changes was observed at 6 and 12. no change was observed in vomiting after surgery . Conclusion:  The results of this study showed that bupivacaine is effective in reducing post-operative nausea.This drug is also easily available.It is recommended that it be used in laparoscopic cholecystectomy


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