Comparison of Hyaluronic Acid with Vitamin E Vaginal Pessaries on Maturation of Vaginal Epithelium in Postmenopausal Women

Document Type : Original Article

Authors

1 Lecturer of Midwifery.Department of Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

2 Assistant Professor of Pharmaciotix. Department of Pharmaciotix, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

3 Lecturer of Vital Statistics.Faculty of Health , Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

4 Department of Patology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Abstract

Background and Objective: Following hot flashes, the second, most common and bothersome menopausal complaint is vaginal atrophy. This symptoms causes vaginal or vulvar dryness, dyspareunia, vaginismus or itching that can significantly affect quality of life. The aim of this study was to compare the effectiveness of vaginal perssaried containing sodium hyaloronate or vitamin E for the treatment of atrophic vaginitis.
Subjects and Methods: This randomized, double-blind clinical trial study was carried out at 17 Shahrivar health center (an educational center in Ahvaz, Iran) from August to December 2010. Forty postmenopausal women with  symptoms  of  vaginal  atrophy were randomized in two groups to administer vaginal  perssaries  of  5  mg  sodium hyaloronate (n=20) or 1mg vitamin E (n=20) for 8 weeks. Vaginal maturation was measured and compared in both groups. The data were analyzed using independent t-test and Paired t test, in SPSS version 16.0. P-values less than 0.05 were considered statistically significant.
Results:The results showed that the vaginal maturation values were significantly improved at both treatment groups (P<0.001). However, the mean maturation value in sodium hyaluronate group was significantly higher when compared with vitamin E group (P<0.001).
Conclusion: Sodium hyaluronate and vitamin E increased  maturation of vaginal epithelium, but improvement was  greater in sodium hyaluronate group. Therefore, sodium hyaluronate vaginal  pessary  is  suggested as an ulternative in women who  do not want  to or cannot  use estrogen  treatment of vaginal  atrophy.

Keywords

References

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Jundishapur Scientific Medical Journal
Volume 11, Issue 4 - Serial Number 79
July and August 2017
Pages 393-401

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History

  • Receive Date: 26 December 2011
  • Revise Date: 04 January 2012
  • Accept Date: 13 March 2012

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