Comparing the Effect of Adding Olanzapine Versus Perphenazine on Maintenance Treatment of Bipolar Type 1

Document Type : Original Article

Authors

1 Assistant Professor of Psychiatry,Department of Psychiatry, School of Medicine , Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

2 Assistant Professor of Psychiarty. Department of Psychiatry, School of Medicine , Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

3 MSc. Student of Education and Psychology. Department of Psychology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Abstract

Background and Objective: Bipolar disorder is one of the most common psychiatric disorder in community. bipolar is an important disorder because of its prevalence and serious complications such as suicide, substance abuse, loss of well being and function, this study was investigated to determine the efficacy of adding perphenazine versus olanzapin in maintenance treatment of bipolar.
Subjects and Methods: this study is an interventional study on 40 bipolar patients (16-50 years old) referred to Golestan hospital psychiatric clinic in 2011. Duration of the study was 8 weeks. Severity of mania was assessed with YMRS at 0,3,6 weeks. The data was analized by using SPSS.
Results: In both groups symptoms were significantly improved at the end of study (p=0.000, p=0.001).
Young mania rating scale between two groups was not significantly different (p=0.2).
Conclusion: Because of small sample size, short duration of study and adding anti psychotic drugs on mood stabilizer, further future works shoude be considered.
 
 

Keywords

References

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Jundishapur Scientific Medical Journal
Volume 11, Issue 1 - Serial Number 76
July and August 2002
Pages 49-56

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History

  • Receive Date: 02 January 2012
  • Revise Date: 09 February 2012
  • Accept Date: 14 February 2012

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