Risk Factors Associated with Diabetic Neuropathy in Type 2 C Patients Referred to Diabetic Clinic of Golestan Hospital, Ahvaz, Iran

Document Type : Original Article

Authors

1 Department of Neurology, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.

2 Department of Endocrinology, Diabetes Research Center, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran.

3 Department of Neurology, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran

4 General Practitioner

Abstract

Background and Objective: Diabetes mellitus is one of the most common endocrine diseases. It affects 5-8% of Iranian population and nearly 177 million people worldwide. The disease predisposes to multiple microvascular complications such as neuropathy; retinopathy and nephropathy. Of these; neuropathy is the most common complication.7% at the time of diagnosis and 50% in the patients with 25 years history of disease suffer from neuropathy. Neuropathy can lead to sensory disturbances; foot ulceration; cellulitis; steomyelitis; gangren and amputation. Some people with diabetes experience painful neuropathy leading to impairment of daily function. Autonomic dysfunction is another debilitating complication of the diabetic neuropathy. In this study the relationship between diabetic neuropathy and a number of risk factors was evaluated.
Subjects and Methods: 150 patients with type 2 diabetes randomly          referred to diabetic clinic of Golestan hospital; Ahvaz, based on Michigan Neuropathic Diabetic Scoring and the nerve conduction study were divided into two groups with and without neuropathy and their relationship with risk factors was evaluated.
Result: From 150 patients with diabetes;39 patients experienced neuropathy and prevalence of neuropathy was 26%.in the study of neuropathy and various risk factors; significant correlation between neuropathy and Age(p<o.oo6); duration of disease(p<0.001); BMI(p<0.05)and MNDS(p<0.001) was ststistically remarkable.
Conclusion: the study reports concluded statistically significant relationship between age;MNDS;duration of disease;retinopathy; hypertention and BMI;thus controlling of blood pressure and weight control;resulting in wheight loss and subsequent better control of glucose;can be causative in delation of diabetic neuropathy

Keywords


cui A, Braunwald O, Kasper D, Hauser S, Longo D, Jameson J, et al, eds. Principles of internal medicine. 17th ed. New York: McGraw-Hill; 2008. P. 2274.
 2-Larijani BZ, Zahedi F. [Epidemiology of diabetes mellitus in Iran]. Iraninan Journal of diabetes and lipid disorders 2002;1:1-8. [In Persian]
3-Tesfaye s, Stevens  LK, Stephenson JM, Fuller JH, Plater M, Ionescu-Tirgoviste C, et al. Prevalence of diabetic peripheral neuropathy and its reation to glycaemic control and potential risk factors: the EURODIAB IDDN Complications Study. Diabetologia 1996;39(11):1377-84.
4-Knuiman MW, Welborn TA, McCann VJ, Stanton KG, Constable IJ. Prevalence of diabetic complications in relation to risk factors. Diabetes 1986;35(12):1332-9.
5-Tesfaye S, Chaturvedi N, Eaton SEM, Ward JD, Manes C, Ionescu-Tirgoviste C, et al. Vascul risk factors and diabetic neuropathy. New Engl J Med 2005;352:341-50.
6-Booya F, Bandarian F, Larijani B, Pajouhi M, Nooraei M, Lotfi J. Potential rik factors for diabetic neuropathy: a case control study. BMC Neurol 2005;5:24.
 
7-Janghorbani  M,Rezvanian H,Kachooei A,Ghorbani A,Chitsaz A,Isadi F,Amin M.peripheral neuropathy in type 2 diabetes mellitus in Isfahan,Iran:prevalence and risk factors.Acta Neurol scand 2006 Dec,114(6):384-91.
8-Valensi P, Giroux C, Seeboth-Ghalayini B, Attali JR. Diabetic peripheral neuropathy: effects of age, duration of diabetes, glycemic control, and Vascular factors. J Diabetes Complications 1997;11(1):27-34.
9-Akbar DH, Mira SA, Zawawi TH, Malibary HM. Subclinical diabetic neuropathy: a common complication in Saudi diabetics. Saudi Med J 2000;21(5):433-7.
10-Yadollah Harati and E. Peter Bosch in chapter 80 ; Walter G. Bradley in neurology in clinical practice; 2008, fifth edition.