Preparation of Yogurt Lyophilized Powder to Achieve a Complementary Tablet

Document Type : Original Article

Authors

1 Department of Pharmaceutics, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

2 Department of Clinical Pharmacy, School of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran

Abstract

Background and Objective: Instability and deterioration of some drugs, vitamins and fatty dairy products in a liquid phase is one of the difficulties in the long-term storage, especially in the case of bulk products. Besides, some of these powder materials do have no enough compressibility to change them in a tablet dosage form and may need technological modification. In present study yogurt was used as a suitable model for the evaluation.
Subjects and Methods: The liquid fresh yogurt was lyophilized at -40  and 0.03 Tor pressure. The dry powder was homogenized by a 12 mesh size sieve. Carr’s compressibility index, Hausner ratio and the angle of repose tests were applied to evaluate porosity, density and therefore the flowability of yogurt powder. Study of deformation of particles during forcing was done by calculation of elastic recovery index.
Results: Carr’s compressibility index and Hausner ratio were 15% and 0.94, respectively. The range of repose angle was between 19-20 . The elastic recovery was obtained 60%. Hardness of tablets increased by decreasing compression velocity, therefore yogurt powder might have a plastic deformation. Tablets with low fat yogurt showed very good compressibility with 6-12 Strong-Cab hardness units.
Conclusion: With respect to selection of the conditions and proper drying method (Liyophilization process), and also to rely on measurable indexes such as: density, porosity and finally compressibility of the powder, preparation of a solid tablet from liquid yogurt for therapeutic and nutritious uses, is possible.   
 

Keywords

References

1-Kolars Jc, Levitt MD, Aouji M, Savaiano DA. Yogurt- an auto-digesting source of lactose. New Engl J Med 1984;310:1-3.
2-Beniwal RS, Arena VC, Thomas L, Narla S, Imperiale TF, Chaudhry RA, et al. A randomized trial of yogurt for prevention of antibiotic-associated diarrhea. Dig Dis Sci 2003;48(10):2077-82.
3-Ingrediants-Yogurt. Available at: URL:http://www.drgourmet.com/ingredients/yogurt.shtml.Retrieved. Accessed Aug 27, 2011.
4-Zeml MB, Richards J, Mathis S, Milstead A, Gebhardt L, Silva E. Dairy augmentation of total and central fat loss in obese subjects. Int J Obes (Lond) 2005;29(4):391-7.
5-Bagda MJ. Tablet compression, Encyclopedia of pharmaceutical technology. New York: Marcel Dekker; 2002. P. 2669.
6-Duberg M, Nystrom C. Studies on direct compression of tablets. XVII. Porosity–pressure curves for the characterization of volume reduction mechanisms in powder compression. Powder Technol 1986;46(1):67–75.
7-Tory DB. Remington: The science and practice of pharmacy. 21st ed. Philadelphia: Lippincott William & Wilkins; 2006.
8-Carr RL. Evaluation of flow properties of solids. Chem Eng (1965);72:163-8.
9-Moghbel A, Abbaspour H. A study on the factors affecting the compressibility of green tea leaves powder to make a herbal tablet. Med Res J Ahvaz Jundishapur Univ Med Sci 2010;8(4):463-78.
10-De Boer AH, Bolhuis GK, Lerk CF. Bonding characteristics by scanning electron microscopy of powders mixed with magnesium stearate. Powder Technol 1978;20(1):75–82.
11-Alderborn G, Pasanen K, Nystrom C. Studies on direct compression of tablets. XI. Characterisation of particle fragmentation during compaction by permeametry measurements of tablets. Int J Pharm 1985;23:79–86.
12-Karehill PG, Glazer M, Nystrom C. Studies on direct compression of tablets. XXIII. The importance of surface roughness for the compactibility of some directly compressible materials with different bonding and volume reduction properties. Int J Pharm 1990;64:35–43.
13-Lachman L, Lieberman HA, Kanig JL. The theory & practice of industrial pharmacy. 3rd ed. Philadelphia: Lea & Febiger; 1986. P. 204.
14-Luangta-Anna M, Fall JT. Bonding mechanisms in tabletting. Int J Pharm 1990;60:197–202.
15-Adolfsson A, Olsson H, Nystr¨om C. Effect of particle size and compaction load on interparticulate bonding structure for some pharmaceutical materials studied by compaction and strength characterization in butanol. Eur J Pharm Biophar 1997;44:243–51.
16-Shotton E, Ganderton D. The strength of compressed tablets. III. The relation of parcticle size, bonding and capping in tablets of sodium chloride, aspirin and hexamine. J Pharm Pharmacol 1961;13(Suppl 1):144–52.
17-McKenna A, McCafferty DF. Effect of particle size on the compaction mechanism and tensile strength of tablets. J Pharm Pharmacol 1982;34(6):347–51.
18-Alderborn G, Nyström C. Studies on direct compression of tablets. III. The effect on tablet strength of changes in particle shape and texture obtained by milling. Acta Pharm Suec 1982;19(2):147–56.
19-Ritter A, Sucker HB. Studies of variables that affect tablet capping. Pharm Tech 1980;3:57–62.
20-von Eggelkraut-Gottanka SG, Abed SA, Müller W, Schmidt PC. Roller compaction and tabletting of St. John's wort plant dry extract using a gap width and force controlled roller compactor. I. Granulation and tabletting of eight different extract batches. Pharm Dev Technol 2002;7(4):433–45.
21-Soares LA, González Ortega G, Petrovick PR, Schmidt PC. Dry granulation and compression of spray-dried plant extracts. AAPS PharmSci Tech 2005;3:359-66.
22-Freitag F, Reincke K, Runge J, Grellmann W, Kleinebudde P. How do roll compaction/dry granulation affect the tableting behaviour of inorganic materials? Microhardness of ribbons and mercury porosimetry measurements of tablets. Eur J Pharm Sci 2004;22(4):325–33.
23-Heckel RW. Institute of Metals Division- Density-Pressure Relationships in Powder Compaction. Trans Metall Soc AIME 1961;221:671–5.
24-Ilkka J, Paronen P. Prediction of the compression behaviour of powder mixtures by the Heckel equation. Int J Pharm 1993;94(1-3):181–7.
25-Kochhar SK, Rubinstein MH, Barnes D. The effects of slugging and recompression on pharmaceutical excipients. Int J Pharm 1995;115(1):35–43.
26-Rue PJ, Rees JE. Limitations of the Heckel relation for predicting powder compaction mechanisms. J Pharm Pharmacol 1978;30(10):642–3.
27-York P. A consideration of experimental variables in the analysis of powder compaction behaviour. J Pharm Pharmacol 1979;31(4):244–6.
28-Sonnergaard JM. A critical evaluation of the Heckel equation. Int J Pharm 1999;193(1):63–71.
29-Pedersen S, Kristensen HG. Change in crystal density of acetylsalicylic acid during compaction. STP Pharm Sci 1994;4(3):201–6.
30-Roberts RJ, Rowe RC. Brittle/ductile behaviour in pharmaceutical materials used in tabletting. Int J Pharm 1987;36(2-3):205–9.
31-Wikberg M, Alderborn G. Compression characteristics of granulated materials II. Evaluation of granule fragmentation during compression by tablet permeability and porosity measurements. Int J Pharm 1990;62:214–29.
32-Ragnarsson G, Sjögren J. Force-displacement measurements in tableting. J Pharm Pharmacol 1985;37(3):145–50.
33-Duberg M, Nyström C. Studies on direct compression of tablets. VI. Evaluation of methods for the estimation of particle fragmentation during compaction. Acta Pharm Suec 1982;19(6):421–36.
Jundishapur Scientific Medical Journal
Volume 12, Issue 1 - Serial Number 82
July and August 2013
Pages 1-12

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History

  • Receive Date: 03 July 2012
  • Revise Date: 06 October 2012
  • Accept Date: 10 November 2012

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