Comparison of alterations in thyroid hormones in severe head injury patients undergoing craniotomy with those who did not

Document Type : Original Article


1 Department of Neurosurgery, School of Medicine, Ahvaz Jundishapur University of Medical Siences, Ahvaz, Iran.

2 Department of Neurosurgery, School of Medicine, Ahvaz Jundishapur University of Medical Siences, Ahvaz, Iran

3 Department of Nursing, Birjand University of Medical Sciences, Birjand, Iran.

4 School of Medicine, Ahvaz Jundishapur University of Medicalsiences,Ahvaz, Iran.


Background and Objective: Different hormonal responses may appear in severe head injured patients. These changes can also be seen during recovery and rehabilitation periods influencing the outcome. The aim of this study was to compare changes in thyroid hormones among severe head injury patients undergone craniotomy with those who did not undergo similar intervention.
Subjects and Methods: In this descriptive cross-sectional study, 59 severe focal brain lesions patients admitted to Ahwaz Golestan Hospital neurosurgery service, having the criteria of inclusion, were selected. The patients were divided into two groups (n=27 each). The first group who underwent brain surgery craniotomy and the second group did not undergo craniotomy. Two serum samples, one was taken after 24 hours and a second was taken on day 5 of admission. Using ELISA tests for T3, T4 and TSH serum levels were measured. Data were analyzed by independent T, and Pearson correlation tests.
Results: Mean serum T4 on the fifth day in patients with severe head injury who had craniotomy was significantly greater than patients who had no craniotomy. The mean serum T4 levels in patients with severe head injury in the first group on the fifth day of the second group of patients had higher and  There was a statistically significant difference between them and the recovery of serum T4 in both groups, there was a correlation (p <0.05).There were relationships between recovery and T4 levels in both groups. Mean serum T3 and TSH serum levels on the fifth day in patients undergone craniotomy were not statistically significant different with patients did not undergo craniotomy.
Conclusion: The results of this study showed that, craniotomy surgery was effective in improving patients with severe head trauma. Furthermore, T4 serum level can be used as a prognostic factor in these patients.


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