The Prevalence of Vitamin D Deficiency in Patients Referred to the Clinical Diagnostic Laboratories in Khuzestan Province in 2014

Document Type : Original Article

Authors

1 MSC Student of Biochemistry Graduate.Department of Biochemistry Graduate, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

2 Assistant Professor of Biochemistry Graduate.Department of Clinical Biochemistry, Cellular and Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Abstract

Background and Objective: Throughout the world, measuring serum 25-hydroxyvitamin D is used to assess serum vitamin D levels. According to this criterion, many epidemiological studies show that vitamin D deficiency is a worldwide health problem and is associated with many chronic diseases. The aim of this study was to evaluate serum levels of vitamin D in Khuzestan province and remark on the need for its treating.    
Subjects and Methods: This cross-sectional study was carried out on 4574 participants of men and women referred to some diagnostic laboratories of Khuzestan Province in 1393. Serum level of 25(OH) vitamin D, as the most important metabolites of vitamin D, was measured by chemiluminescence method and vitamin D deficiency was defined at 25-hydroxy vitamin D level of less than 30 ng / ml.
Results: Based on the statistic analysis the mean serum level of 25(OH)VitD was 21.40 ± 18.36  ng/mL 77.8% of  participants  were assessed  as the severe to mild VitD deficiency.  The VitD average for male and female were 21.45 ± 16.03 and 21.38 ± 19.00  ng / ml respectively and it was in insuficiency range for both sexes.
Conclusion: In this study, it was found that despite the sunny climate of Khuzestan, the serum level of  vit D is low in study parcipitants and the mean reasons for this deficiency can be due to very low intake of vitamin D through foods, fear of exposure to the sun ray, or incorrect assessments of the normal values of Vit D.

Keywords


1-Garcion E, Wion-Barbot N, Montero-Menei CN, Berger F, Wion D. New clues about vitamin D functions in the nervous system. Trends Endocrin Metab 2002; 13(3): 100-5.
2-Heaney RP. Vitamin D in health and disease. Clin J Ame Soci Nephrol 2008Sep; 3(5): 1535-41.
3-Holick MF. Vitamin D deficiency. New England J Med 2007; 357(3): 266-81.
4-Prüfer K, Veenstra TD, Jirikowski GF, Kumar R. Distribution of 1, 25-dihydroxyvitamin D3 receptor immunoreactivity in the rat brain and spinal cord. J chem neuroana1999 Feb;16(2):135-45.
5-Nataf S, Garcion E, Darcy F, Chabannes D, Muller J, Brachet P. 1, 25 Dihydroxyvitamin D3 exerts regional effects in the central nervous system during experimental allergic encephalomyelitis. J Neuropathol Exp Neurol 1996Aug; 55(8): 904-14.
6-Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Ame j Clin Nutr 2004Mar;79(3): 362-71.
7-Targher G, Bertolini L, Padovani R, Zenari L, Scala L, Cigolini M, "et al". Serum 25‐hydroxyvitamin D3 concentrations and carotid artery intima‐media thickness among type 2 diabetic patients. Clin Endocrinol(OXF) 2006Nov; 65(5): 593-7.
8-Takiishi T, Van Belle T, Gysemans C, Mathieu C. Effects of vitamin D on antigen‐specific and non‐antigen‐specific immune modulation: relevance for type 1 diabetes. Pediatr Diabetes 2013Mar; 14(2): 81-9.
9-Amital H, Szekanecz Z, Szücs G, Danko K, Nagy E, Csepany T, "et al". Serum concentrations of 25-OH vitamin D in patients with systemic lupus erythematosus (SLE) are inversely related to disease activity: is it time to routinely supplement patients with SLE with vitamin D? Ann Rheumatic Dis 2010Jun; 69(6):1155-7.
10-Harandi AA, Harandi AA, Pakdaman H, Sahraian MA. Vitamin D and multiple sclerosis. Iranian J Neurol 2014; 13(1):1.
11-Feldman D, Krishnan AV, Swami S, Giovannucci E, Feldman BJ. The role of vitamin D in reducing cancer risk and progression. Nat Rev Cancer 2014May; 14(5): 342-57.
12-Kaur H, Donaghue KC, Chan AK, Benitez-Aguirre P, Hing S, "et al". Vitamin D deficiency is associated with retinopathy in children and adolescents with type 1 diabetes. Diabetes Care 2011Jun; 34(6):1400-2.
13-Tai K, Need AG, Horowitz M, Chapman IM. Vitamin D, glucose, insulin, and insulin sensitivity. Nutrition 2008; 24(3): 279-85.
14-Ginde AA, Liu MC, Camargo CA. Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004. Archives Internal Med 2009; 169(6): 626-32.
15-Ferder M, Inserra F, Manucha W, Ferder L. The world pandemic of vitamin D deficiency could possibly be explained by cellular inflammatory response activity induced by the renin-angiotensin system. Am J Physiol-Cell Physiol 2013Jun; 304(11): C1027-C39.
16-Vieth R, Bischoff-Ferrari H, Boucher BJ, Dawson-Hughes B, Garland CF, Heaney RP, "et al". The urgent need to recommend an intake of vitamin D that is effective. Ame J Clin Nutr 2007; 85(3): 649-50.
17-Oberhelrnan S, Thacher T. Vitamin D deficiency in the 21 “century: an overview. Handbook of Vitamin D in Human Health: Prevention, Treatment and Toxicity. USA: Wageningen Academic Publishers; 2013.
18-Yetley EA. Assessing the vitamin D status of the US population. Ame J Clin Nutr 2008Aug; 88(2): 558S-64S.
19-Keane E, Rochfort A, Cox J, McGovern D, Coakley D, Walsh J. Vitamin-D-fortified liquid milk–a highly effective method of vitamin D administration for house-bound and institutionalised elderly. Gerontol1992; 38(5): 280-4.
20-Raiten DJ, Picciano MF. Vitamin D and health in the 21st century: bone and beyond. Executive summary. Ame J Clin Nutr 2004; 80(6):1673S-7S.
21-Neyestani TR, Hajifaraji M, Omidvar N, Eshraghian MR, Shariatzadeh N, Kalayi A, "et al". High prevalence of vitamin D deficiency in school-age children in Tehran, 2008: a red alert. Pub Health Nutr 2012Feb; 15(02): 324-30.
22-MoradZadeh K LB, Keshtkar AA, Hossein Nezhad A, Rajabian R, Nabi Poor I, "et al". Normal values of vitamin D and prevalence of vitamin D deficiency among Iranian population. Kurdistan U Med Sci 2006; 10: 33-43.
23-Shakiba M  RP. Prevalence of Vitamin D Deficiency Among Medical Staff in  Shahid Sadoughi Hospital in Yazd, Iran. Tolloo-E-Behasht 2007; 7(25): 22-30.
24-Rabbani A, Alavian S-M, Motlagh ME, Ashtiani MT, Ardalan G, Salavati A, "et al". Vitamin D insufficiency among children and adolescents living in Tehran, Iran. J Tropical Pediatr 2009; 55(3):189-91.
25-Razzaghy-Azar M, Shakiba M. Assessment of vitamin D status in healthy children and adolescents living in Tehran and its relation to iPTH, gender, weight and height. Ann Hum Biol 2010; 37(5): 692-701.
26-Talaei A, Yadegari N, Rafee M, Rezvanfar MR, Moini A. Prevalence and cut-off point of vitamin D deficiency among secondary students of Arak, Iran in 2010. Indian J Endocrinol Metab 2012; 16(5):786.
27-Moussavi M, Heidarpour R, Aminorroaya A, Pournaghshband Z, Amini M. Prevalence of vitamin D deficiency in Isfahani high school students in 2004. Horm Res 2005; 64: 144-8.
28-Rahimi AO, Zarghami N, Sadighi A. Relationship between vitamin D and nutritional status in healthy reproductive age women. Inter J Endocrinol Metabolism 2006Jan; 4(1): 1-7.
29-Sadat-Ali M, AlElq A, Al-Turki H, Al-Mulhim F, Al-Ali A. Vitamin D levels in healthy men in eastern Saudi Arabia. Ann Saudi Med 2009; 29(5): 378.

30-Holick MF. Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol 2009; 19(2):73-8. PubMed PMID: PMC2665033.