Efficacy of Tranexamic Acid in Reducing Blood Loss During Bilateral Mandible Fracture Trauma Surgery Kazem

Document Type : Original Article


1 Assistant Professor of Oral and Maxillofacial Surgery.

2 Assistant Professor of Anesthesiology

3 Assistant Professor of Oral and Maxillofacial Surgery

4 Department of Oral and Maxillofacial Surgery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

5 Department of Oral and Maxillofacial Radiology, Faculty of dentistry, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

6 Department of Physical Therapist , Ahvaz Jundishapur University of Medical Scienc0es, Ahvaz, Iran.


Background and Objectives: Tranexamic acid is effective in reducing the risk of death due to blood loss in trauma cases. The aim of this study was to assess the efficacy of tranexamic acid compared to normal saline in bilateral mandible fracture due to accident
Subjects and Methods: Thirty six patients (both male and female) between the ages of 20-40 yr, with bilateral mandible fractures due to accident were assessed in Imam Khomeini Hospital, Ahvaz, Iran, in 2014.  Eighteen patients received intravenously20 mg/kg tranexamic acid bolus as intervention group and 18 patients received normal saline as control group just before induction of anesthesia. Intra-operative blood loss and pre- and post-operative hemoglobin were recorded for both groups.
Results: Tranexamic acid significantly reduced the volume of blood loss during surgery when compared with control group (360.57±173.52 mL vs 506.96±248.07 mL). The average drop in hemoglobin was 1.08 mg/dl in the tranexamic group and 1.54mg/dl in the saline group.
Conclusion: Prescribing pre-operative tranexamic acid intravenously at 20 mg/kg reduces blood loss compared with placebo during the surgery.


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