Effect of Kiwifruit Extract (Actinidia deliciosa) on Body Weight, Thyroid Hormones, Pain and Memory in Hypothyroidism Male Rats

Authors

1 Department of Biology, Sciences Faculty, Fars Islamic Azad University, Shiraz, Iran. 2-Department of Biology, Faculty of Basic Sciences, Payamenoor University, Tehran East Division, Tehran, Iran.

2 Department of Biology, Faculty of Basic Sciences, Payamenoor University, Tehran East Division, Tehran, Iran.

3 Ahvaz Physiology Research Center, Jundishpur University of Medical Sciences, Ahvaz,Iran.

4 Department of Physiology, Medicine Faculty, Jundishpur University of Medical Sciences, Ahvaz, Iran.

Abstract

Background and Objectives: Oxidative stress due to hypothyroidism causes behavioral deficits. Kiwifruit contains various vitamins and antioxidants. In this study the effect of kiwifruit extract on body weight, memory, pain and serum T4 and T3 in hypothyroidism male rats was evaluated.
Subjects and Methods: Wistar male rats(200-250g)were dividedinto 8 groups (n=8) randomely as following: 1) Control, the remaining groups were hypothyroidism that received methimazole (500mg/L in drinking water) for 3 weeks. 2-7) Treated groups received orally either different doses of Kiwifruit extract (50,100,150, 200, 400 mg/kg/5ml or the same volume of normal saline for 14 days. 8) Positive control group receiving 1 mg/L of levothyroxine in drinking water. Serum thyroid hormones (with radioimmunoassay), body weight, pain (by tail-flick test), and memory (by shutle box) were measured for all groups. Data were analyzed with one-way ANOVA followed by Tukey’s post hoc and PResults: Serum T4 and T3, body weight and memory and pain reflex latency were decreased significantly after induction of hypothyroidism (P<0.01). Treatment with 150 and 200 mg/kg doses, without affecting the thyroid hormone serum level, improved memory and pain significantly (P<0.001) Higher doses of extract had no effect on above parameters.
Conclusion: Treatment with kiwifruit extract didn’t change thyroid hormones; therefore, had no effect on hypothalamus-pituitary-thyroid axis.
Improving effects of Kiwifruit extract on behavioral deficits following hypothyroidism might be related to its antioxidant property in brain.
 

Keywords

References

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Jundishapur Scientific Medical Journal
Volume 14, Issue 2 - Serial Number 95
May and June 2015
Pages 128-139

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History

  • Receive Date: 26 August 2014
  • Revise Date: 21 January 2015
  • Accept Date: 04 March 2015

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