The Effect of Six Weeks Consumption of Pomegranate Juice and Aerobic Training on Paraoxonase-1 and Plasma Lipid Profile in Adult Women with Diabetes Type II

Document Type : Original Article


1 Associate Professor of Sport Physiology. Department of sport Physiology, Ayatollah Amoli Branch, Islamic Azad University ,amol, amol, Iran.

2 Assistant Professor of Laboratory Medicine.Department of Laboratory Medicine, Research Center Hyperlipidemia, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

3 Assistant Professor of Sport Physiology. Department of sport Physiology, Ayatollah Amoli Branch, Islamic Azad University ,amol, amol, Iran.


Background and Objective:  Diabetes increases oxidative stress in different tissues and leads to increased levels of oxidation of DNA, proteins and lipids. Paraoxonase is an esterase enzyme that is carried along with HDL-C. This enzyme prevents of the peroxidation of LDL-C and therefore effective in reducing the risk of atherosclerosis.
Subjects and Methods: In this clinical trial study the subjects of this research included diabetic postmenopausal women in the city of Babol with the age range between 50 and 60 years old.   Who were selected with coordination of Diabetes Association. The statistical sample included 33 subjects who were randomly divided into four groups (n=7 to 9). These groups were randomely divided into: control, pomegranate juice, exercise and exercise-pomegranate juice. Program of aerobic training groups was for six weeks, three times in a week and for 45-65 minutes/day and in four afternoon was carried out. Subjects consume 150 ml of pomegranate juice daily at eight o'clock every morning.. For the analysis data from the Dependent t-test and  analysis of variance one way ANOVA was used.
Results: There was a highly significant increase in the paraoxonase-1 (P<0/05) and HDL, as well as a significant decrease in levels of TG, TC and LDL (P<0/05) before and after the experimental period in the group of subjects.
Conclusion: activity of paraoxonase enzyme and Plasma lipid profile can be influenced by dietary factors and lifestyle.


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