The Comparison Effect of Different Cardiac Rehabilitation Protocols on Renin-Angiotensin Enzymes System in Patients after Coronary Artery Bypass Graft Surgery

Document Type : Original Article


1 PhD Student in Exercise Physiology.Department of Exercise Physiology, University of martyr Rajai Teacher Training, Tehran, Iran.

2 Associate Professor of Exercise Physiology.Department of Exercise Physiology, University of martyr Rajai Teacher Training, Tehran, Iran.

3 Associate Professor of Exercise Physiology,Department of Exercise Physiology, Faculty of Physical Education and Sport Science, Kharazmi University, Tehran, Iran.

4 Associate Professor of Cardiology.Department of Cardiology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.


Background and Objective: Exercise training based on cardiac rehabilitation can lead to improvement of cardiac function and regulatory hormones involved in blood pressure homeostasis. The aim of this study was to compare the effects of different protocols of cardiac rehabilitation on plasma levels of rennin-angiotensin enzyme system in cardiovascular patients after CABG operation.
Subjects and Methods: In present semi-experimental research forty patients after CABG operation were selected targetly, and divided randomly in four groups: control (n=10), aerobic-continuous (n=10), aerobic interval–resistant (n=10), and aerobic continuous–resistant (n=10). Plasma levels of angiotensin I, angiotensin II, and ACE-2 were measured by ELIZA method before and after cardiac rehabilitation protocols. Two way ANOVA used for statistical analysis (P<0.05).
Results: Following implementation of cardiac rehabilitation protocols, a significant decrease in angiotensin II and a significant increase in angiotensin I were found in comparison with control group (P<0.05). But there were no significant differences between intervention groups (P>0.05). After cardiac rehabilitation periods there were no significant differences between ACE-2 levels among control and intervention groups (P>0.05).
Conclusion: Cardiac rehabilitation programs with consumption of AT1R Inhibitors drugs such as: Losartan, are important way for improvement in cardiovascular function and blood pressure reduction.


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