Jundishapur Scientific Medical Journal

Jundishapur Scientific Medical Journal

Increasing the Expression of Nlrp3 Gene in the Liver Tissue of Non-alcoholic Fatty Liver Disease Model Rats in the Interaction of Soy Supplementation and Aerobic Training During Fasting

Document Type : Original Article

Authors
Elham Shojarazavi 1
Habib Asgharpour 2
Neda Aghaii bahmanbeghloo 2
1 PhD Student in Exercise Physiology, Department of Physical Education & Sports Sciences, AK.C., Islamic Azad University, Aliabad Katoul, Iran
2 Assistant Professor, Department of Physical Education & Sports Sciences, AK.C., Islamic Azad University, Aliabad Katoul, Iran
10.22118/jsmj.2025.464741.3580
Abstract
Background and Objectives NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) is a cytosolic sensor that modulates inflammatory responses in nucleated cells by detecting various danger signals. The aim of the present study was to determine the effect of continuous aerobic exercise, starvation, and soy protein consumption on NLRP3 expression in liver tissue of a model of nonalcoholic fatty liver disease (NAFLD).
Subjects and Methods In the present experimental study, 60 NAFLD model rats were randomly divided into 12 groups of 5, including control, fasting, 3 days of exercise, 5 days of exercise, fasting + 3 days of exercise, fasting + 5 days of exercise, supplement, supplement + 3 days of exercise, supplement + fasting + 5 days of exercise, supplement + fasting + 3 days of exercise, supplement + fasting + 5 days of exercise, and supplement + fasting. The expression of the NLRP3 gene in liver tissue was measured by real-time method.
Results A significant decrease in NLRP3 expression was observed in the supplement + fasting + 5 days of exercise group compared to the control and 3 days of exercise groups (P <0.05). Also, the reduction of NLRP3 expression in the supplement + fasting + 3 days of exercise group was significant compared to the control group (P <0.05).
Conclusion  Based on the findings of the present study, reducing NLRP3 expression requires a combination of interventions, especially exercise in fasting conditions along with soy consumption.
Keywords
Non-alcoholic fatty liver disease
Fasting
Soy protein
NOD-
LRR- and pyrin domain-containing protein 3
Subjects
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Published by ahvaz jundishapur university of medical science. This article is an open access article licensed under the Creative Commons Attribution-NonCommercial 4.0 (https://creativecommons.org/licenses/by-nc/4.0/).
 
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  • Receive Date 25 June 2024
  • Revise Date 17 January 2025
  • Accept Date 25 January 2025