Jundishapur Scientific Medical Journal

Jundishapur Scientific Medical Journal

Microbial, genetic and trace element factors associated with skin cancer

Document Type : Review

Authors
Negar Dinarvand 1
Fatemeh Torabi 2
Zahra Hasanvand 3
Reza Azizi 4
1 Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
2 Student Research Committee, Khomein University of Medical Sciences, Khomein, Iran.
3 General Office of Education, Education Department of Markazi Province, Markazi Province, Iran.
4 Department of Laboratory Sciences, Khomein University of Medical Sciences, Khomein, Iran
10.32592/JSMJ.23.3.223
Abstract
Skin cancer is one of the most common types of cancer worldwide. In addition to ultraviolet radiation which is a well-known contributing factor, other potential factors have recently been proposed that may contribute to the development of skin cancer. Therefore, the aim of this study is the investigating the role of skin microbiota factors, trace elements and genetic factors in the risk of skin cancer. Scientific articles available in PubMed، Google Scholar, and Web of Science (WOS) databases were utilized for this study. Various studies have shown that microbial dysbiosis in human microbiota is one of the effective factors in the development and treatment of skin cancer. Additionally, research has explored the association between skin cancer and exposure to trace elements such as arsenic, cadmium, chromium, copper, iron, selenium, and zinc. While some studies indicate that exposure to arsenic is associated with an increased risk of keratinocyte cancer, contradictory results have been reported regarding the role of other elements. Furthermore, some diseases and genetic disorders such as basal cell carcinoma and malignant melanoma predispose individuals to skin cancers. Given the substantial prevalence of skin cancer and the paucity of existing research, further investigations into risk factors and preventive measures are imperative.
Keywords
Skin cancer
Microbiota
Trace elements
Genetic disorders
Subjects

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    • Christenson LJ, Borrowman TA, Vachon CM, Tollefson MM, Otley CC, Weaver AL, Roenigk RK. Incidence of basal cell and squamous cell carcinomas in a population younger than 40 years. Jama. 2005 Aug 10;294(6):681-90. [1001/jama.
      294.6.681      ] [PMID]
    • 병호오. Pathogenesis and prevention of skin cancer. Journal of the Korean Medical Association. 2018 Nov 1;61(11):644-8.
    • Ries LA, Eisner MP, Kosary CL, Hankey BF, Miller BA, Clegg L, Mariotto A, Feuer EJ, Edwards BK. SEER cancer statistics review. National Cancer Institute. 1975;2004.
    • Nikolaou V, Stratigos AJ. Emerging trends in the epidemiology of melanoma. British journal of dermatology. 2014 Jan 1;170(1):11-9. [1111/bjd.12492] [PMID]
    • Guy Jr GP, Thomas CC, Thompson T, Watson M, Massetti GM, Richardson LC, Centers for Disease Control and Prevention (CDC). Vital signs: melanoma incidence and mortality trends and projections-United States, 1982-2030. MMWR Morb Mortal Wkly Rep. 2015 Jun 5;64(21):591-6. [PMID]
    • Woo YR, Cho SH, Lee JD, Kim HS. The human microbiota and skin cancer. International Journal of Molecular Sciences. 2022 Feb 5;23(3):1813. [3390/ijms23031813] [PMID]
    • Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI. The human microbiome project. Nature. 2007 Oct 18;449(7164):804-10. [1038/nature06244] [PMID]
    • IARC I. Beryllium, cadmium, mercury, and exposures in the glass manufacturing industry. IARC monographs on the evaluation of carcinogenic risks to humans. 1993;58:41-117. [PMID]
    • Lyon F. IARC monographs on the evaluation of carcinogenic risks to humans. World health organization, International agency for research on cancer. availble at publication@ iarc. fr. 2014.
    • Alam M, Nanda S, Mittal BB, Kim NA, Yoo S. The use of brachytherapy in the treatment of nonmelanoma skin cancer: a review. Journal of the American Academy of Dermatology. 2011 Aug 1;65(2):377-88. [1016/j.jaad.2010.03.027] [PMID]
    • Samarasinghe V, Madan V. Nonmelanoma skin cancer. Journal of cutaneous and aesthetic surgery. 2012 Jan 1;5(1):3-10. [4103/0974-2077.94323] [PMID]
    • Fahradyan A, Howell AC, Wolfswinkel EM, Tsuha M, Sheth P, Wong AK. Updates on the management of non-melanoma skin cancer (NMSC). InHealthcare 2017 Nov 1 (Vol. 5, No. 4, p. 82). MDPI. [3390/healthcare5040082] [PMID]
    • Kullander J, Forslund O, Dillner J. Staphylococcus aureus and squamous cell carcinoma of the skin. Cancer Epidemiology Biomarkers & Prevention. 2009 Feb 1;18(2):472-8. [1158/
      1055-9965.EPI-08-0905      ] [PMID]
    • Madhusudhan N, Pausan MR, Halwachs B, Durdević M, Windisch M, Kehrmann J, Patra V, Wolf P, Boukamp P, Moissl-Eichinger C, Cerroni L. Molecular profiling of keratinocyte skin tumors links Staphylococcus aureus overabundance and increased human β-defensin-2 expression to growth promotion of squamous cell carcinoma. Cancers. 2020 Feb 26;12(3):541. [3390/cancers12030541] [PMID]
    • Wood DL, Lachner N, Tan JM, Tang S, Angel N, Laino A, Linedale R, Lê Cao KA, Morrison M, Frazer IH, Soyer HP. A natural history of actinic keratosis and cutaneous squamous cell carcinoma microbiomes. MBio. 2018 Nov 7;9(5):10-128. [1128/mBio.
      01432-18      ] [PMID]
    • Cogen AL, Yamasaki K, Sanchez KM, Dorschner RA, Lai Y, MacLeod DT, Torpey JW, Otto M, Nizet V, Kim JE, Gallo RL. Selective antimicrobial action is provided by phenol-soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin. Journal of Investigative Dermatology. 2010 Jan 1;130(1):192-200. [1038/jid.2009.243] [PMID]
    • Cogen AL, Yamasaki K, Muto J, Sanchez KM, Crotty Alexander L, Tanios J, Lai Y, Kim JE, Nizet V, Gallo RL. Staphylococcus epidermidis antimicrobial δ-toxin (phenol-soluble modulin-γ) cooperates with host antimicrobial peptides to kill group A Streptococcus. PloS one. 2010 Jan 5;5(1):e8557. [1371/
      journal.pone.0008557      ] [PMID]
    • Laborel-Préneron E, Bianchi P, Boralevi F, Lehours P, Fraysse F, Morice-Picard F, Sugai M, Sato'o Y, Badiou C, Lina G, Schmitt AM. Effects of the Staphylococcus aureus and Staphylococcus epidermidis secretomes isolated from the skin microbiota of atopic children on CD4+ T cell activation. PLoS One. 2015 Oct 28;10(10):e0141067. [1371/journal.pone.0141067] [PMID]
    • Nakatsuji T, Chen TH, Butcher AM, Trzoss LL, Nam SJ, Shirakawa KT, Zhou W, Oh J, Otto M, Fenical W, Gallo RL. A commensal strain of Staphylococcus epidermidis protects against skin neoplasia. Science Advances. 2018 Feb 28;4(2):
      [10.1126/sciadv.aao4502] [PMID]
    • Wang J, Aldabagh B, Yu J, Arron ST. Role of human papillomavirus in cutaneous squamous cell carcinoma: a meta-analysis. Journal of the American Academy of Dermatology. 2014 Apr 1;70(4):621-9. [1016/j.jaad.2014.01.857] [PMID]
    • Rollison DE, Viarisio D, Amorrortu RP, Gheit T, Tommasino M. An emerging issue in oncogenic virology: the role of beta human papillomavirus types in the development of cutaneous squamous cell carcinoma. Journal of virology. 2019 Apr 1;93
      (7):10-128. [1128/JVI.01003-18] [PMID]
    • Mizuhashi S, Kajihara I, Sawamura S, Kanemaru H, Makino K, Aoi J, Makino T, Masuguchi S, Fukushima S, Ihn H. Skin microbiome in acral melanoma: Corynebacterium is associated with advanced melanoma. The Journal of dermatology. 2021 Jan;48(1):e15-6. [1111/1346-8138.15633] [PMID]
    • Wang L, Yi T, Kortylewski M, Pardoll DM, Zeng D, Yu H. IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway. Journal of experimental medicine. 2009 Jul 6;206(7):
      1457-64. [1084/jem.20090207] [PMID]
    • Ridaura VK, Bouladoux N, Claesen J, Chen YE, Byrd AL, Constantinides MG, Merrill ED, Tamoutounour S, Fischbach MA, Belkaid Y. Contextual control of skin immunity and inflammation by Corynebacterium. Journal of Experimental Medicine. 2018 Mar 5;215(3):785-99. [1084/jem.2017
      1079      ] [PMID]
    • Tsuda K, Yamanaka K, Linan W, Miyahara Y, Akeda T, Nakanishi T, Kitagawa H, Kakeda M, Kurokawa I, Shiku H, Gabazza EC. Intratumoral injection of Propionibacterium acnes suppresses malignant melanoma by enhancing Th1 immune responses. PLoS One. 2011 Dec 21;6(12):e29020. [1371/journal.pone.
      0029020      ] [PMID]
    • Wang Z, Choi JE, Wu CC, Di Nardo A. Skin commensal bacteria Staphylococcus epidermidis promote survival of melanocytes bearing UVB‐induced DNA damage, while bacteria Propionibacterium acnes inhibit survival of melanocytes by increasing apoptosis. Photodermatology, photoimmunology & photomedicine. 2018 Nov;34(6):405-14. [1111/phpp.12411] [PMID]
    • Mrázek J, Mekadim C, Kučerová P, Švejstil R, Salmonová H, Vlasáková J, Tarasová R, Čížková J, Červinková M. Melanoma-related changes in skin microbiome. Folia microbiologica. 2019 May 15;64:435-42. [1007/s12223-018-00670-3] [PMID]
    • Zhou Z, Chen J, Yao H, Hu H. Fusobacterium and colorectal cancer. Frontiers in Oncology. 2018 Oct 15;8:371. [3389/
      fonc.2018.00371      ] [PMID]
    • Gur C, Ibrahim Y, Isaacson B, Yamin R, Abed J, Gamliel M, Enk J, Bar-On Y, Stanietsky-Kaynan N, Coppenhagen-Glazer S, Shussman N. Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack. Immunity. 2015 Feb 17;42(2):344-55. [1016/j.immuni.2015.01.010] [PMID]
    • Placa ML, Ambretti S, Bonvicini F, Venturoli S, Bianchi T, Varotti C, Zerbini M, Musiani M. Presence of high‐risk mucosal human papillomavirus genotypes in primary melanoma and in acquired dysplastic melanocytic naevi. British Journal of Dermatology. 2005 May 1;152(5):909-14. [1111/j.1365-2133.2005.06344.x] [PMID]
    • Cun B, Song X, Jia R, Wang H, Zhao X, Liu B, Ge S, Fan X. Cell growth inhibition in HPV 18 positive uveal melanoma cells by E6/E7 siRNA. Tumor Biology. 2013 Jun;34:1801-6. [1007/
      s13277-013-0719-x      ] [PMID]
    • Schanab O, Humer J, Gleiss A, Mikula M, Sturlan S, Grunt S, Okamoto I, Muster T, Pehamberger H, Waltenberger A. Expression of human endogenous retrovirus K is stimulated by ultraviolet radiation in melanoma. Pigment cell & melanoma research. 2011 Aug;24(4):656-65. [1111/j.1755-148X.2011.
      00860.x      ] [PMID]
    • Salava A, Deptula P, Lyyski A, Laine P, Paulin L, Väkevä L, Ranki A, Auvinen P, Lauerma A. Skin microbiome in cutaneous T-cell lymphoma by 16S and whole-genome shotgun sequencing. Journal of Investigative Dermatology. 2020 Nov 1;140(11):
      [ 10.1016/j.jid.2020.03.951] [PMID]
    • Balkwill FR, Capasso M, Hagemann T. The tumor micro-environment at a glance. Journal of cell science. 2012 Dec 1;125(23):5591-6. [1242/jcs.116392] [PMID]
    • Kovács P, Csonka T, Kovács T, Sári Z, Ujlaki G, Sipos A, Karányi Z, Szeőcs D, Hegedűs C, Uray K, Jankó L. Lithocholic acid, a metabolite of the microbiome, increases oxidative stress in breast cancer. Cancers. 2019 Aug 27;11(9):1255. [3390/
      cancers11091255      ] [PMID]
    • Johnson CH, Spilker ME, Goetz L, Peterson SN, Siuzdak G. Metabolite and microbiome interplay in cancer immuno- Cancer research. 2016 Nov 1;76(21):6146-52. [10.1158/0008-5472.CAN-16-0309] [PMID]
    • Yang Y, Misra BB, Liang L, Bi D, Weng W, Wu W, Cai S, Qin H, Goel A, Li X, Ma Y. Integrated microbiome and metabolome analysis reveals a novel interplay between commensal bacteria and metabolites in colorectal cancer. Theranostics. 2019;9(14):
      4101. [7150/thno.35186] [PMID]
    • Yu J, Luo Y, Zhu Z, Zhou Y, Sun L, Gao J, Sun J, Wang G, Yao X, Li W. A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor. Journal of Allergy and Clinical Immunology. 2019 Jun 1;143(6):2108-19. [1016/j.jaci.2018.
      11.036      ] [PMID]
    • González‐Sánchez P, DeNicola GM. The microbiome (s) and cancer: know thy neighbor (s). The Journal of Pathology. 2021 Jul;254(4):332-43. [1002/path.5661] [PMID]
    • Chen D, He J, Li J, Zou Q, Si J, Guo Y, Yu J, Li C, Wang F, Chan T, Shi H. Microbiome and metabolome analyses reveal novel interplay between the skin microbiota and plasma metabolites in psoriasis. Frontiers in Microbiology. 2021 Mar 16;12:
      [10.3389/fmicb.2021.643449] [PMID]
    • Rastelli M, Cani PD, Knauf C. The gut microbiome influences host endocrine functions. Endocrine reviews. 2019 Oct;40(5):
      1271-84. [1210/er.2018-00280] [PMID]
    • Clarke G, Stilling RM, Kennedy PJ, Stanton C, Cryan JF, Dinan TG. Minireview: gut microbiota: the neglected endocrine organ. Molecular endocrinology. 2014 Aug 1;28(8):1221-38. [1210/me.2014-1108] [PMID]
    • Sicard JF, Le Bihan G, Vogeleer P, Jacques M, Harel J. Interactions of intestinal bacteria with components of the intestinal mucus. Frontiers in cellular and infection microbiology. 2017 Sep 5;7:387. [3389/fcimb.2017.00387] [PMID]
    • Vereecke L, Beyaert R, van Loo G. Enterocyte death and intestinal barrier maintenance in homeostasis and disease. Trends in molecular medicine. 2011 Oct 1;17(10):584-93. [1016/j.molmed.2011.05.011] [PMID]
    • Ridlon JM, Devendran S, Alves JM, Doden H, Wolf PG, Pereira GV, Ly L, Volland A, Takei H, Nittono H, Murai T. The ‘in vivo lifestyle’of bile acid 7α-dehydroxylating bacteria: comparative genomics, metatranscriptomic, and bile acid metabolomics analysis of a defined microbial community in gnotobiotic mice. Gut microbes. 2020 May 3;11(3):381-404. [1080/194
      90976.2019.1618173      ] [PMID]
    • Tutka K, Żychowska M, Reich A. Diversity and composition of the skin, blood and gut microbiome in rosacea—a systematic review of the literature. Microorganisms. 2020 Nov 8;8(11):
      [10.3390/microorganisms8111756] [PMID]
    • Yan D, Issa N, Afifi L, Jeon C, Chang HW, Liao W. The role of the skin and gut microbiome in psoriatic disease. Current dermatology reports. 2017 Jun;6:94-103. [1007/s13671-017-0178-5] [PMID]
    • Lee SY, Lee E, Park YM, Hong SJ. Microbiome in the gut-skin axis in atopic dermatitis. Allergy, asthma & immunology research. 2018 Jul;10(4):354-62. [4168/aair.2018.10.4.354] [PMID]
    • Lee YB, Byun EJ, Kim HS. Potential role of the microbiome in acne: a comprehensive review. Journal of clinical medicine. 2019 Jul 7;8(7):987. [3390/jcm8070987] [PMID]
    • Matthews NH, Fitch K, Li WQ, Morris JS, Christiani DC, Qureshi AA, Cho E. Exposure to trace elements and risk of skin cancer: a systematic review of epidemiologic studies. Cancer Epidemiology, Biomarkers & Prevention. 2019 Jan 1;28(1):3-21. [1158/1055-9965.EPI-18-0286] [PMID]
    • Hu G, Wang T, Liu J, Chen Z, Zhong L, Yu S, Zhao Z, Zhai M, Jia G. Serum protein expression profiling and bioinformatics analysis in workers occupationally exposed to chromium (VI). Toxicology letters. 2017 Aug 5;277:76-83. [1016/j.toxlet.
      2017.05.026      ] [PMID]
    • Haby MM, Soares A, Chapman E, Clark R, Korc M, Galvão LA. Interventions that facilitate sustainable development by preventing toxic exposure to chemicals: an overview of systematic reviews. Revista Panamericana de Salud Publica. 2016;39:378-86.[PMID]
    • King KE, Darrah TH, Money E, Meentemeyer R, Maguire RL, Nye MD, Michener L, Murtha AP, Jirtle R, Murphy SK, Mendez MA. Geographic clustering of elevated blood heavy metal levels in pregnant women. BMC public health. 2015 Dec;15:1-2. [1186/s12889-015-2379-9] [PMID]
    • Katner A, Lackovic M, Streva K, Paul V. Evaluation of available data sources to prioritize parishes for arsenic monitoring and outreach related to private well drinking water. Journal of Public Health Management and Practice. 2015 Mar 1;21:S93-101. [1097/PHH.0000000000000177] [PMID]
    • Schierbeck J, Vestergaard T, Bygum A. Skin cancer associated genodermatoses: a literature review. Acta dermato-venereologica. 2019 Apr 1;99(4):360-9. [2340/00015555-3123] [PMID]
    • Larsen AK, Mikkelsen DB, Hertz JM, Bygum A. Manifestations of Gorlin-Goltz syndrome. Dan Med J. 2014 May 1;61(5):
      A4829. [PMID]
    • Abuzahra F, Parren LJ, Frank J. Multiple familial and pigmented basal cell carcinomas in early childhood–Bazex–Dupré–Christol syndrome. Journal of the European Academy of Dermatology and Venereology. 2012 Jan;26(1):117-21. [
      1111/j.1468-3083.2011.04048.x      ] [PMID]
    • Achatz MI, Coloma MC, de Albuquerque Cavalcanti Callegaro E. Risk Factors for Skin Cancer. InOncodermatology: An Evidence-Based, Multidisciplinary Approach to Best Practices 2023 Jul 19 (pp. 37-55). Cham: Springer International Publishing.
    • Lehmann AR, McGibbon D, Stefanini M. Xeroderma pigmentosum. Orphanet journal of rare diseases. 2011 Dec;6:1-6. [1186/1750-1172-6-70] [PMID]
    • Smith JF. A case of multiple primary squamous‐celled carcinomata of the skin in a young man, with spontaneous healing. British Journal of Dermatology. 1934 Jun 1;46(6):267-72.
    • Smith JF. A case of multiple primary squamous‐celled carcinomata of the skin in a young man, with spontaneous healing. British Journal of Dermatology. 1934 Jun 1;46(6):267-72.
    • John AM, Schwartz RA. Muir-Torre syndrome (MTS): an update and approach to diagnosis and management. Journal of the American Academy of Dermatology. 2016 Mar 1;74(3):558-66. [1016/j.jaad.2015.09.074] [PMID]
    • Ferreira FR, Santos LD, Tagliarini FA, Lira ML. Porokeratosis of Mibelli-literature review and a case report. Anais Brasileiros de Dermatologia. 2013;88(6 Suppl 1):179-82. [1590/abd1806-4841.20132721] [PMID]
    • Bygum A, Betz R, Kragballe K, Steiniche T, Peeters N, Wuyts W, Nöthen M. KID Syndrome: Report of a Scandinavian Patient with Connexin‐26 Gene Mutation. Acta dermato-venereologica. 2005 Mar 1;85(2). [1080/00015550410024148] [PMID]
    • Wang LL, Plon SE. GeneReviews®: Rothmund-Thomson Syndrome. GeneReviews®: Seattle, WA, USA. 1993. [PMID]
    • Larizza L, Roversi G, Volpi L. Rothmund-thomson syndrome. Orphanet journal of rare diseases. 2010 Dec;5:1-6. [1186/1750-1172-5-2] [PMID]
    • Arora H, Chacon AH, Choudhary S, McLeod MP, Meshkov L, Nouri K, Izakovic J. Bloom syndrome. International journal of dermatology. 2014 Jul;53(7):798-802. [1111/ijd.12408] [PMID]
    • Burger B, Itin PH. Epidermodysplasia verruciformis. Human Papillomavirus. 2014;45:123-31. [1159/000356068] [PMID]
    • Lynch HT, Krush AJ. Heredity and malignant melanoma: implications for early cancer detection. Canadian Medical Association Journal. 1968 Jul 7;99(1):17. [PMID]
    • Soura E, Eliades PJ, Shannon K, Stratigos AJ, Tsao H. Hereditary melanoma: Update on syndromes and management: Emerging melanoma cancer complexes and genetic counseling. Journal of the American Academy of Dermatology. 2016 Mar 1;74(3):411-20. [1016/j.jaad.2015.08.037] [PMID]
    • Rai K, Pilarski R, Cebulla CM, Abdel‐Rahman MH. Comprehensive review of BAP1 tumor predisposition syndrome with report of two new cases. Clinical genetics. 2016 Mar;89(3):285-94. [1111/
      cge.12630      ] [PMID]
Jundishapur Scientific Medical Journal
Volume 23, Issue 3 - Serial Number 150
July and August 2024
Pages 223-232

  • Receive Date 02 January 2024
  • Revise Date 16 April 2024
  • Accept Date 29 April 2024