Effect of 12 Weeks of Resistance Training on the Serum Levels of Interleukin-10 and Interleukin-15 in Middle-aged Women

Document Type : Original Article


Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khorramabad, Iran.



Background:Aging is generally associated with a progressive decrease in physical activity, which can affect the quality of life and lead to negative structural and functional changes in different body tissues and reduce their efficiency.High levels of interleukin-10 and interleukin-15 cytokines are related to longevity. The aim of this study is the effect of 12 weeks of resistance training on the serum levels of interleukin-10 and interleukin-15 in middle-aged women.
Subjects and Methods:40 middle-aged women (40-59 years old) were selected and randomly divided into2 equal experimental and control groups. The experimental group performed a resistance training program with a training load of 65% to 80%1RM for 12 weeks.Finally,48 hours after the last exercise, the levels of interleukin-10 and interleukin-15 were measured by ELISA method. The Kolmogorov Smirnov test was used to compare the data, and the independent t-test was used for the effectiveness of the exercise at a significance level of P<0.05.
Results:The findings showed that there is no difference in weight and BMI between the experimental and control groups before the start of the research (P<0.05). But after training, it was statistically significant (P< 0.05).Also, a significant increase was observed in the levels of interleukin-10 and interleukin-15 after training(P=0.001).
Conclusion:It seems that the increased regulation of anti-inflammatory cytokines can have a positive effect on the improvement of physiological conditions caused by resistance training in middle-aged women. Therefore, it is recommended to use strength training to improve the levels of cytokines to increase the strength and performance of muscle mass.



Shabnam Mohammadinejad [PumMed] [Google Scholar]

Masoud Rahmati [PumMed] [Google Scholar]

Rahim Mirnasouri [PumMed] [Google Scholar]


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