Epidermal Growth Factor Receptor in Lung Adenocarcinoma Patients: A Retrospective Cross-sectional Study to Clarify the Discrepancy

Document Type : Original Article


1 Full Professor, Department of Pathology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

2 General Practitioner, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

3 Associate Professor, Department of Hematology-oncology, Shahvali Hospital, Azad University of Medical Sciences, Yazd, Iran.

4 Internal medicine resident, Shahid Sadoughi Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran



Epidermal growth factor receptor prognostic role in lung adenocarcinoma patients

Background and objectives: It seems that EGFR tyrosine kinase inhibitors can be used to increase survival in non-small cell cancers. In this study, we intend to investigate the relationship between the occurrence of EGFR factor with other demographic variables and see if its occurrence or non-occurrence has an effect on patient survival or not.
Materials and methods: In the current cross-sectional analytical study, 54 patients with lung adenocarcinoma referred to Shahid Sadoughi and Mortaz hospitals in Yazd during 2015-2016 were included in the study. Data were analyzed using SPSS version 20 software.
Results: The average age of the patients (32 men and 22 women) was 59.64 ± 14.79 years. 13 (24.1%) patients were EGFR positive. There was no significant relationship between EGFR status and survival rate (P>0.05). Also, no significant relationship was found between tumor location, tumor grade, and survival rate (P>0.6, 0.7). However, a significant relationship was observed between the survival rate and the age and gender of the patients (p<0.01, p<0.02).
Conclusion: According to these data, the elderly and male gender have a reduced chance of survival in individuals with lung adenocarcinoma. Furthermore, EGFR might not be a strong prognostic predictor, according to our findings.


Shokouh Taghipour zahir [PumMed] [Google Scholar]

 Sajad Sadeghinejad-Alamabadi [PumMed] [Google Scholar]

 Seyed Mohammadreza Mortazavizadeh [PumMed] [Google Scholar]

Farzan SafiDaha [PumMed] [Google Scholar]


Main Subjects

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