Role of High-intensity Interval Training in Developing Healthy Metabolic Obesity by Reducing the Serum Levels of Asprosin, Leptin, and Insulin among Inactive Obese Women

Document Type : Original Article


1 PhD Student of Exercise Physiology, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Isfahan, Isfahan, Iran

2 Assistant Professor, Department of Sports Physiology, Faculty of Physical Education and Sport Sciences, University of Isfahan, Isfahan, Iran.

3 Assistant Professor, Department of Laboratory Sciences, Faculty of Paramedical Sciences, Aja University of Medical Sciences, Tehran, Iran.



Background and Objectives Obesity-induced metabolic disorders are related to the metabolic syndrome. The present study aimed to assess the effect of high-intensity interval training on body mass index (BMI) and serum levels of leptin, asprosin, insulin, and fasting glucose in inactive obese women. Subjects and Methods In this quasi-experimental research, 24 sedentary obese women were purposefully selected and randomly assigned to two groups of exercise and control(n=12 in each group). The intervention involved three sessions of high-intensity weekly interval training per week for 10 weeks. The control group did not receive any exercise intervention. Fasting blood samples were obtained 24 hours before the commencement of the intervention and 72 hours after the last training session. Statistical analysis involved paired sample t-tests and covariance analysis. Results Based on the results, after the intervention, there was a significant decrease in asprosin (η2=0.352; F=0.390; P=0.003), leptin (η2=0.478; F=19.229; P< 0.001) and insulin (η2=0.681; F=44.828; P<0.001) levels in the intervention group compared to the control group. Nonetheless, no significant difference was observed in BMI and fasting blood glucose (P>0.05). Conclusion As evidenced by the results of this research, high-intensity interval training had positive effects on cytokines related to energy homeostasis and hyperinsulinemia in obese women without causing any weight change.


Maryam Salehi [PumMed] [Google Scholar]

Fahimeh Esfarjani [PumMed] [Google Scholar]

 Sattar Gorgani Firoozjaei [PumMed] [Google Scholar]



Main Subjects

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