Ovulation induction in patients with resistant polycystic ovarian syndrome: Comparative study of the efficacy of metformin and inofolic

Document Type : Original Article


1 Department of Obstetrics and Gynecology, School of medicine, Ahvaz Jundishapur university of Medical sciences, Iran

2 Department of Obstetrics and Gynecology, School of medicine Fertility Infertility and perinatology Research Center Imam Khomeini Hospital, Jundishapur University of Medical Sciences, Ahvaz, Iran.

3 Fertility Infertility and perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.



Background and purpose: Medicines that reduce insulin levels along with increasing insulin sensitivity have created great hope for the treatment of polycystic ovary syndrome. The aim of this study is to compare the effectiveness of metformin and inofolic in inducing ovulation in patients with resistant polycystic ovary syndrome.
Methodology: This randomized clinical trial study was conducted on 40 patients referred to the infertility clinic with PCOS. Patients were randomly divided into two groups: metformin (receive 1 tablet of 500 mg twice a day) and inofolic (receive 1 sachet twice a day, half an hour before breakfast and half an hour before dinner). The treatment continued for 3 months. During the treatment period, both groups underwent ovulation stimulation (received 5 days of oral administration (clomiphene citrate tablet 100 mg daily or letrozole tablet 5 mg daily)) as well as injectable gonadotropin.
Results: The presence of at least one mature follicle in both groups was completely similar, and the number of mature follicles in both groups had a relatively similar pattern (P = 0.26). The pregnancy rate in the group receiving inofolic and metformin was 25% and 15%, respectively.
Conclusion: The findings of the present study showed that the effectiveness of inositol in terms of improving ovarian function and the occurrence of pregnancy in PCOS patients is similar to metformin.


Main Subjects

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6]Commented [M : : Reference 27 and 28 are the same.