Vitamin E Reduces Kidney Damage Caused by Ecstasy in Mice

Document Type : Original Article

Authors

1 Assistant Professor, Department of Anatomical sciences, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

2 Nephrology and kidney transplant Research Center, Clinical Research Institute, Urmia University of Medical Sciences, Urmia, Iran.

3 Medical student of Urmia University of medical sciences, school of medicine, Urmia, Iran.

4 Associated Professor, Department of anatomical sciences, school of medicine, Urmia University of Medical Sciences. Urmia, Iran.

Abstract

Background and Objectives Ecstasy is one of the most famous derivatives of amphetamine. The aim of the present study was to evaluate the effects of vitamin E on ecstasy-induced kidney histological damage in mice. Subjects and Methods This study included five weeks of intervention on 28 male albino mice that were divided into four groups: control, ecstasy (10 mg/kg ecstasy intraperitoneally), ecstasy + vitamin E 150 mg/kg through gavage), vitamin E solvent (olive oil). Kidney tissues were evaluated histologically by H&E and Masson’s trichrom staining methods. Serum urea and creatinine levels were also measured. Results Tissue changes were indicative of kidney tissue disorder in the ecstasy group. Evaluation of renal fibrosis showed that in the ecstasy group, large areas of fibrosis were seen in the kidney tissue, and in the glomerular structure and renal tubules. On the other hand, the degree of fibrosis in the group receiving vitamin E was significantly lower compared with the ecstasy group. Also, taking ecstasy caused a significant increase in serum creatinine and urea compared to the control group. However, vitamin E improved these conditions. Conclusion Ecstasy consumption can lead to glomerular infiltration, Bowman capsule injury, and renal fibrosis. In contrast, the use of vitamin E treatment after taking ecstasy can significantly inhibit the progression of injury.

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Main Subjects


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