The Use of Nano-carriers in Transdermal Drug delivery

Document Type : Review


1 department of pharmaceutics, faculty of pharmacy, AJUMS, IRAN

2 Resident of Clinical Pharmacy.Department of Clinical Pharmacy, Faculty of Pharmacy, Shahid Beheshti University of Medical, Tehran, Iran.

3 PhD Student in chemical Engineering.Petroleum Research Laboratory, School of Chemical Engineering, Iran University of Science and Technology, Tehran, Iran.


Objective: Transdermal permeability refers to the delivery of medication to the body through the skin for local or systemic treatment. Transdermal drug delivery systems have not liver first pass effect and gastrointestinal adverse reaction. The use of chemical penetration enhancers and physical absorption systems are obsolete because there are expensive and changes of the skin structure, and the future look at the use of novel drug delivery systems. Nano-carriers is one of the most important new technologies in the field of novel drug delivery. Nanoparticle formulations have about 10 to 100 nanometers. Smaller particles are absorbing more easily than the surface of the skin. Methods: In the present study, a review of previous studies on the use of Nano technology in transdermal drug delivery systems introduced them and their transdermal permeability was paid. Conclusion: Nanotechnology in different routes and formulations has the ability to increase the permeability of therapeutic drugs depending on their characteristics, the physicochemical characteristics of the drugs, and the therapeutic goals one can choose.


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