Association Between Maternal Age with Maternal hematological indices and Anthropometric status in Neonatal: A Case-Control Study

Document Type : Original Article


1 jundishapoor university of medical science

2 PhD of Nutrition,Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Khozestan, Iran.

3 PhD of Nutrition.Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Khozestan, Iran.

4 Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Khozestan, Iran.


Background and Objective: This study was conducted to determine the relationship between maternal age during pregnancy and maternal hematological parameters and anthropometric status in neonatal.
Methods: In this study, 32 mothers aged 35 years and older (case group) and 292 mothers aged 20-35 years (control group) were examined. Maternal age and hematologic parameters were evaluated before delivery. The weight, height and head circumference were measured in infants. The relationship between prenatal age of mothers and infant’s anthropometric indices were calculated using the Pearson correlation coefficient.
Results: The comparison between the two groups showed no significant difference in the type of delivery, history of abortion, systolic and diastolic blood pressure and hematological parameters. In addition, there was no significant difference between the two groups in the sex, weight, head circumference and height of the infants. A significant negative correlation was observed between prenatal age of mothers with the number of monocyte (Mid) cells (P <0.05), number of red blood cells (P<0.05), number of white blood cells, and granulocytes (P<0.001) in mothers. Also, a significant correlation was observed between the prenatal age of mothers with number of low birth weight (LBW) (Positively, P<0.01), weight (Negatively, P<0.01), head circumference (Negatively, P<0.001) of infants.
Conclusion: The results of this study showed that the number of infants with LBW increases with increasing mother's age. Also, maternal age can significantly associate with some maternal hematological parameters and the anthropometric indices of infant.


1-Pariente G, Wainstock T, Walfisch A, Sheiner E, Harlev AJFd, therapy. Advanced Maternal Age and the Future Health of the Offspring. 2019;46(2):139-46.
2-Sydsjö G, Pettersson ML, Bladh M, Svanberg AS, Lampic C, Nedstrand EJBp, et al. Evaluation of risk factors’ importance on adverse pregnancy and neonatal outcomes in women aged 40 years or older. 2019;19(1):92.
3-Sauer MVJF, sterility. Reproduction at an advanced maternal age and maternal health. 2015;103(5):1136-43.
4-Yerebasmaz N, AKDAĞ DC, Özdemirci Ş, ERTÜRK S, KAYIKÇIOĞLU F. Does Advanced Maternal Age Increase the Risk of Adverse Perinatal Outcomes? Acta Medica. 2017;46(1).
5-Jahromi BN, Husseini Z. Pregnancy outcome at maternal age 40 and older. Taiwanese journal of obstetrics and gynecology. 2008;47(3):318-21.
6-Smith GC, Cordeaux Y, White IR, Pasupathy D, Missfelder-Lobos H, Pell JP, et al. The effect of delaying childbirth on primary cesarean section rates. PLoS medicine. 2008;5(7):e144.
7-Smith C, Ryckman K, Barnabei VM, Howard B, Isasi CR, Sarto G, et al. The impact of birth weight on cardiovascular disease risk in the Women's Health Initiative. 2016;26(3):239-45.
8-Organization WH. 2012-2013 biennium report: Department of Nutrition for Health and Development: evidence and programme guidance. World Health Organization; 2014.
9-Johnson C, Jones S, Paranjothy S, Wales N. Low Birth Weight. 2014.
10-Gedefaw L, Ayele A, Asres Y, Mossie AJEjohs. Anaemia and associated factors among pregnant women attending antenatal care clinic in Walayita Sodo town, Southern Ethiopia. 2015;25(2):155-64.
11-Nair M, Gireesh S, Yakoob R, Cheriyan N. Effect of maternal anaemia on birth weight of term babies. International Journal of Contemporary Pediatrics. 2018;5(3):1019-22.
12-Osonuga I, Osonuga O, Onadeko A, Osonuga A, Osonuga A. Hematological profile of pregnant women in southwest of Nigeria. Asian Pacific Journal of Tropical Disease. 2011;1(3):232-4.
13-Shaw J, Dey S, Critchley H, Horne A. Current knowledge of the aetiology of human tubal ectopic pregnancy. Human reproduction update. 2010;16(4):432-44.
14-James TR, Reid HL, Mullings AM. Are published standards for haematological indices in pregnancy applicable across populations: an evaluation in healthy pregnant Jamaican women. BMC pregnancy and childbirth. 2008;8(1):8.
15-Elgari MM. Evaluation of hematological parameters of sudanese pregnant women attending at Omdurman Al Saudi Maternity Hospital. Egypt Acad J Biolog Sci. 2013;5(1):37-42.
16-Jensen JD, Wiedmeier SE, Henry E, Silver RM, Christensen RD. Linking maternal platelet counts with neonatal platelet counts and outcomes using the data repositories of a multihospital health care system. American journal of perinatology. 2011;28(08):597-604.
17-Akbarzadeh M, Zare NJSJoIBTO. Relationship between maternal hematologic concentration and BMI in primiparous women on some physiological parameters in neonates. 2013;10(1):77-85.
18-Kenny LC, Lavender T, McNamee R, O’Neill SM, Mills T, Khashan AS. Advanced maternal age and adverse pregnancy outcome: evidence from a large contemporary cohort. PloS one. 2013;8(2):e56583.
19-Wennberg AL, Opdahl S, Bergh C, Henningsen A-KA, Gissler M, Romundstad LB, et al. Effect of maternal age on maternal and neonatal outcomes after assisted reproductive technology. Fertility and sterility. 2016;106(5):1142-9. e14.
20-Delpisheh A, Brabin L, Attia E, Brabin BJ. Pregnancy late in life: a hospital-based study of birth outcomes. Journal of women's health. 2008;17(6):965-70.
21-Başer E, Seçkin KD, Erkılınç S, Karslı MF, Yeral IM, Kaymak O, et al. The impact of parity on perinatal outcomes in pregnancies complicated by advanced maternal age. Journal of the Turkish German Gynecological Association. 2013;14(4):205.
22-Guimarães AM, Bettiol H, Souza LD, Gurgel RQ, Almeida MLD, Ribeiro ERDO, et al. Is adolescent pregnancy a risk factor for low birth weight? Revista de saude publica. 2013;47:11-9.
23-Strobino DM, Ensminger ME, Kim YJ, Nanda JJAJoE. Mechanisms for maternal age differences in birth weight. 1995;142(5):504-14.
24-Allen LH. Anemia and iron deficiency: effects on pregnancy outcome–. The American journal of clinical nutrition. 2000;71(5):1280S-4S.
25-Benoist Bd, McLean E, Egll I, Cogswell M. Worldwide prevalence of anaemia 1993-2005: WHO global database on anaemia. Worldwide prevalence of anaemia 1993-2005: WHO global database on anaemia. 2008.
26-Mularz A, Gutkin R. Maternal age and successful induction of labor in the United States, 2006–2010. Obstetrics & Gynecology. 2014;123:73S.
27-Lamminpää R, Vehviläinen-Julkunen K, Gissler M, Heinonen S. Preeclampsia complicated by advanced maternal age: a registry-based study on primiparous women in Finland 1997–2008. BMC pregnancy and childbirth. 2012;12(1):47.
28-Joseph KS, Allen AC, Dodds L, Turner LA, Scott H, Liston R. The perinatal effects of delayed childbearing. Obstetrics & Gynecology. 2005;105(6):1410-8.