Evaluation of Thyroid Functional Disorders in Preeclampsia Patients

Document Type : Original Article

Authors

1 Associate Professor of Obstetrics and Gynecology.Department of Obstet and Gynecol, Obstetrics and Gynecology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

2 Assistant Professor of Obstetrics and Gynecology.Department of Obstetrics and Gynecology, Member of the Student Research Committee, Fetus Fertility and Infertility Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

3 Associate Professor of Diabetes and Endocrinology.Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

4 Resident of Obstetrics and Gynecology,Department of Obstetrics and Gynecology, Member of the Student Research Committee, Fetus Fertility and Fertility Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Abstract

Background and Objective: Preeclampsia is a multiple system disorder characterized by blood pressure and protein deficiency in the second half of pregnancy. Several factors, such as genetic and environmental factors, are involved in the onset of this disorder. Considering the results from a survey conducted and the possibility of increased risk of thyroid disorders in mothers with preeclampsia, this study evaluated the level of thyroid dysfunction in patients with preeclampsia.
Subjects and Methods: This study was a cross-sectional study which was conducted on 79 pregnant women with pre-eclampsia and 79 healthy pregnant women admitted to Imam Khomeini Hospital, Ahvaz. Sampling was performed using a sequential non-probability sampling method. At the end of the study, data were analyzed using descriptive statistics (mean and percentage) and analytical statistics (independent T-test) or its nonparametric equivalent methods.
Results: The mean age of the patient group was 28.4 ± 6.5 y and in the healthy group was 29.3 ±6 y. The mean of gestational age in the patient group was 258.8 ± 22.3 y and 254.5 ± 22.7 y in the healthy group. Analysis shows that there was no significant difference between the levels of thyroid hormones in both groups. Statistical analysis showed patients with normal pregnancy and pre-eclampsia had significantly higher anti-TPO than healthy group (P<0.001).
Conclusion: According to these results, the incidence of preeclampsia can exacerbate the level of thyroid disorders, but this does not seem to be statistically significant. Therefore, mothers who are at risk for preeclampsia should be monitored for thyroid function and should be treated appropriately if necessary, to prevent the exacerbation of this dangerous condition.

Keywords

References

 
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Jundishapur Scientific Medical Journal
Volume 16, Issue 5 - Serial Number 110
November and December 2017
Pages 565-573

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History

  • Receive Date: 19 November 2016
  • Revise Date: 28 July 2017
  • Accept Date: 05 August 2017

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