Virus-Like Particle: Structure, Characteristics and Application in Vaccine

Document Type : Review

Authors

1 ph.D student of Nanobiotechnology at I.H.University, Tehran, Iran

2 Assistant Professor of Biochemistry.Department of Biology, Faculty of Basic Science, Imam Hossein University, Tehran, Iran.

3 Professor of Biology.Department of Biology, Faculty of Basic Science, Imam Hossein University, Tehran, Iran.

4 Ms.c Student in Cell and Molecular Biology.Department of Biology Research Center, Faculty of Basic Science, Imam Hossein University, Tehran, Iran.

Abstract

Virus-like particles (VLPs) are a group of subunit vaccines, which due to a stronger protective immunogenicity, are distinguished from soluble recombinant antigens. Like native viruses, virus-like particles can be both enveloped and non-enveloped. They are formed from the expression of one or more viral structural proteins in a heterologous system. Depending on the complexity of the VLP, the proteins can be produced in prokaryotic or eukaryotic expression systems, or in certain cases, they can be manufactured and assembled in the cell-free conditions. Virus-like particles can be produced in a range of cell culture systems, including mammalian cell lines, insect cells, yeast, plant cells and cell-free conditions. To date, a wide range of VLP-based vaccine candidates against viral, bacterial, parasitic, and fungal pathogens, as well as non-infectious diseases, have been produced in various expression systems. Some of VLPs have entered clinical development and few of them have licensed and commercialized.

Keywords

References

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Jundishapur Scientific Medical Journal
Volume 16, Issue 5 - Serial Number 110
November and December 2017
Pages 575-589

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History

  • Receive Date: 16 May 2016
  • Revise Date: 09 August 2017
  • Accept Date: 12 August 2017

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