The Effect of 12 Weeks High Intensity Interval Training and Resistance Training on Liver Fat, Liver Enzymes and Insulin Resistance in Men with Nonalcoholic Fatty Liver

Document Type : Original Article

Authors

1 Department of exercise physiology, faculty of humanities, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran.

2 Lecturer ofExercise Physiology.Department of Exercise Physiology, Faculty of Humanities, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran.

Abstract

Background and Objective: Nonalcoholic fatty liver disease is the most prevalent liver disease in the world. Life style modification particularly physical activity is the most important treatment strategy. The purpose of the present study was to examine effect of resistance training and high intensity interval training on fatty liver biochemical indices, insulin resistance and liver fat.
Subjects and Methods: A total 22 with nonalcoholic fatty liver men enrolled and randomized to resistance training or high intensity interval training. The resistance training group performed six multi joint exercises at 65-70 % 1RM. Interval training group performed 6-12 × 60 s intervals at 80-85 % HRmax, each interval separated with 2 min active rest. Both training groups performed training three times per week. The plasma concentration of liver amino transferase enzymes, lipid profile, insulin resistance index and liver fat measured pre- and 72-h after the last training session. The paired sample T test and independent sample T test used for analysis of changes within group and between group differences, respectively.
Results: The plasma ALT concentration significantly decreased in resistance (P= 0.046) and interval (P= 0.011) training groups. The fasting insulin and insulin resistance index in both groups (P≤ 0.001). The liver fat decreased in both groups. The lipid profile significantly improved in both groups. No significant differences observed between groups in any parameter.
Conclusion: It seems that both resistance and interval training are appropriate training strategy for non-alcoholic fatty liver patent and can improve plasma ALT, lipid profile, insulin resistance and liver fat.
 

Keywords

References

1-Balducci S, Cardelli P, Pugliese L, D’Errico V, Haxhi J, Alessi E, et al. Volume-dependent effect of supervised exercise training on fatty liver and visceral adiposity index in subjects with type 2 diabetes The Italian Diabetes Exercise Study (IDES). Diabetes research and clinical practice. 2015;109(2):355-63.
2-Freidoony L, Kong ID. Practical approaches to the nutritional management of nonalcoholic fatty liver disease. Integrative Medicine Research. 2014;3(4):192-7.
3-Skrypnik D, Ratajczak M, Karolkiewicz J, Mądry E, Pupek-Musialik D, Hansdorfer-Korzon R, et al. Effects of endurance and endurance–strength exercise on biochemical parameters of liver function in women with abdominal obesity. Biomedicine & Pharmacotherapy. 2016;80:1-7.
4-Vasques MO, Andreato LV, Almeida F, Esteves JDC, de Souza RF, de Moraes SF. Strength training improves plasma parameters, body composition and liver morphology in ovariectomized rats. Science & Sports. 2012;27(2):94-100.
5-Keating SE, Hackett DA, Parker HM, O’ConnorHT, Gerofi JA, Sainsbury A, et al. Effect of aerobic exercise training dose on liver fat and visceral adiposity. Journal of hepatology. 2015;63(1):174-82.
6-Schultz A, Mendonca LS, Aguila MB, Mandarim-de-Lacerda CA. Swimming training beneficial effects ina mice model of nonalcoholic fattyliverdisease. Experimental and Toxicologic Pathology. 2012;64:273–82.
7-Slentz CA, Bateman LA, Willis LH, Shields AT, Tanner CJ, Piner LW, et al. Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT. American Journal of Physiology-Endocrinology and Metabolism. 2011;301(5):E1033-E9.
8-Thoma C, Day CP, Trenell MI. Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: a systematic review. Journal of hepatology. 2012;56(1):255-66.
9-Hallsworth K, Fattakhova G, Hollingsworth KG, Thoma C, Moore S, Taylor R, et al. Resistance exercise reduces liver fat and its mediators in non-alcoholic fatty liver disease independent of weight loss. Gut. 2011:gut. 2011.242073.
10-Zelber‐Sagi S, Nitzan‐Kaluski D, Goldsmith R, Webb M, Zvibel I, Goldiner I, et al. Role of leisure‐time physical activity in nonalcoholic fatty liver disease: A population‐based study. Hepatology. 2008;48(6):1791-8.
11-Keating SE, Hackett DA, George J, Johnson NA. Exercise and non-alcoholic fatty liver disease: a systematic review and meta-analysis. Journal of hepatology. 2012;57(1):157-66.
12-Johnson NA, Sachinwalla T, Walton DW, Smith K, Armstrong A, Thompson MW, et al. Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss. Hepatology. 2009;50(4):1105-12.
13-Mir A, Aminai M, Marefati H. The impression of aerobic exercises to enzymes measure and liver fat in the man suffering to non-alcoholic fatty liver. Int Res J Appl Basic Sci. 2012;3(9):1897-901.
14-Marcinko K, Sikkema SR, Samaan MC, Kemp BE, Fullerton MD, Steinberg GR. High intensity interval training improves liver and adipose tissue insulin sensitivity. Molecular metabolism. 2015;4(12):903-15.
15-Barzegarzadeh-Zarandi H, Dabidy-Roshan V. Changes in some liver enzymes and blood lipid level following interval and continuous regular aerobic training in old rats. Journal of Shahrekord University of Medical Sciences. 2012;14(5):13-23.
16-Barani F, Afzalpour ME, Ilbiegi S, Kazemi T, Mohammadi Fard M. The effect of resistance and combined exercise on serum levels of liver enzymes and fitness indicators in women withnonalcoholic fatty liver disease. Journal of Birjand University of Medical Sciences. 2014;21(2):188-202.
17-Kistler KD, Brunt EM, Clark JM, Diehl AM, Sallis JF, Schwimmer JB, et al. Physical activity recommendations, exercise intensity, and histologicalseverity of nonalcoholic fatty liver disease. The American journal of gastroenterology. 2011;106(3):460.
18-Heijden GJ, Wang ZJ, Chu ZD, Sauer PJ, Haymond MW, Rodriguez LM, et al. A 12‐Week Aerobic Exercise Program Reduces Hepatic Fat Accumulation and Insulin Resistance in Obese, Hispanic Adolescents. Obesity. 2010;18(2):384-90.
19-Hood MS, Little JP, Tarnopolsky MA, Myslik F, Gibala MJ. Low-volume interval training improves muscle oxidative capacity in sedentary adults. Medicine and science in sportsand exercise. 2011;43(10):1849-56.
20-Bompa TO, Haff G. Periodization: Theory and Methodology of Training: Human Kinetics; 2009.
21-Vilar CP, Cotrim HP, Florentino GS, Barreto CP, Florentino AVA, Bragagnoli G, et al. Association between nonalcoholic fatty liver disease and coronary artery disease. Revista da Associação Médica Brasileira (English Edition). 2013;59(3):290-7.
22-Brzycki M. A Practical Approach to Strength Training: Blue River Press; 2012.
23-Heyward VH, Gibson A. Advanced Fitness Assessment and Exercise Prescription 7th Edition: Human Kinetics; 2014.
24-Frayn KN. Visceral fat and insulin resistance—causative or correlative? British Journal of Nutrition. 2000;83(S1):S71-S7.
25-Chang Y, Ryu S, Sung E, Jang Y. Higher concentrations of alanine aminotransferase within the reference interval predict nonalcoholic fatty liver disease. Clinical Chemistry. 2007;53(4):686-92.
26-Church TS, Kuk JL, Ross R, Priest EL, Biltoff E, Blair SN. Association of cardiorespiratory fitness, body mass index, and waist circumference to nonalcoholic fatty liver disease. Gastroenterology. 2006;130(7):2023-30.
27-Kantartzis K, Rettig I, Staiger H, Machann J, Schick F, Scheja L, et al. An extended fatty liver index to predict non-alcoholic fatty liver disease. Diabetes & Metabolism. 2017;43(3):229-39.
28-Galedari M, Azarbayejani Ma. The effect of training mode during calorie restriction on plasma adipokines and fasting insulin in obese men. Sport Physiology. 2015;6(24):121-38.
Jundishapur Scientific Medical Journal
Volume 16, Issue 5 - Serial Number 110
November and December 2017
Pages 493-503

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History

  • Receive Date: 16 May 2016
  • Revise Date: 09 August 2017
  • Accept Date: 12 August 2017

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