Evaluation of Physiochemical, Compressibility and Mechanical Properties of Quince Seeds Powder and Troche Tablets

Document Type : Original Article

Authors

Department of Pharmaceutics, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Abstract

Background and Objective: Because of the potential therapeutic effects of quince seeds mucilage to ameliorate cough and control of asthma sings and previous confirmed animal studies, the aim of the present study was to select a suitable drying method for preparation of a powder to produce a troche tablet.
Subjects and Methods: With about 100 g of the mucilage powder was dried by two methods of oven and freeze drying and granulated by the wet method, tablets with 800 mg weight were prepared by a single punch tablet machine in 5 different granulation sizes of 212, 500, 710, 850, and 1700 mm. The granules and prepared tablets were examined for their physico-chemical, compressibility, packing factor, tensile strength, and mechanical properties.
Results: Density of the powder prepared by the cold method was 60% less than the warm method. Compressibility index and Hunser ratio with the results of 8 and 10 for compressibility and 0.9 and 1 for Hunser ratio were different by 20 and 10% for two methods respectively. Percentage porosity  was 0.7 and 0.25 and angle of repose 23 and 28 for the coldand warm method respectively. The strength power for different granulation sizes of the powder dried by cold method had a direct proportionality, and an inverse relationship for friability test respectively.
Conclusion: Tablets prepared with the mucilage dried by cold method had larger particle sizes and more favorable physiochemical properties, which can be selected for preparation of quince seed troche tablets

Keywords

References

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Jundishapur Scientific Medical Journal
Volume 13, Issue 6 - Serial Number 93
November and December 2017
Pages 731-740

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History

  • Receive Date: 26 October 2014
  • Revise Date: 20 December 2014
  • Accept Date: 30 December 2014

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