Comparison of Quality of life, Thyroid Hormones, and Blood Glucose in Active and Inactive Pregnant Women

Document Type : Original Article

Authors

1 BSc in Psychology, ACER Khuzestan, Ahvaz, Iran

2 Assistant Professor, ACER Khuzestan, Ahvaz, Iran

3 Ph.D. in Exercise Physiology, ACER Khuzestan, Ahvaz, Iran

10.32592/JSMJ.22.2.225

Abstract

Background and Objectives Pregnancy is one of the most important periods of a woman's life, which affects most body systems due to the extensive metabolic needs of pregnancy. This research aimed to compare quality of life, thyroid function, and blood glucose profile in active and inactive pregnant women. Subjects and Methods In the present study, 120 pregnant women were purposefully selected from the pregnant women who were referred to the women's Clinic of Amir al-Momenin and Social Security Hospital in Ahvaz, Khuzestan province, Iran, in 2022. The activity and inactivity of pregnant women were based on the Pregnancy Physical Activity Questionnaire (PPAQ). In addition, the participants completed the quality of life questionnaires (WHOQOL-BREF). To measure thyroid hormones and sugar profile, blood sampling was done in the Hospital Laboratory while fasting. The data were analyzed using multivariate analysis of variance and independent t-test. Results The results of the present research showed that active pregnant women had significantly higher quality of life and T3 and T4 hormones compared to inactive pregnant women. Furthermore, active pregnant women had significantly lower fasting blood glucose, two-hour blood glucose, and thyroid-stimulating hormone compared to inactive pregnant women. Conclusion Overall, the present study emphasizes the importance of the role of physical activity on the psychological and physiological variables of pregnant women and suggests exercise interventions in future research.

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Main Subjects


[1] Downe S, Finlayson K, Tunçalp Ӧ, Metin Gülmezoglu A. What matters to women: a systematic scoping review to identify the processes and outcomes of antenatal care provision that are important to healthy pregnant women. BJOG. 2016;123(4): 529-39. [DOI: 10.1111/1471-0528.13819] [PMID]
[2] Parrettini S, Caroli A, Torlone E. Nutrition and metabolic adaptations in physiological and complicated pregnancy: focus on obesity and gestational diabetes. Front Endocrinol (Lausanne). 2020;11:611929. [DOI: 10.3389/fendo.2020. 611929] [PMID] [PMCID]
[3] Kazma JM, van den Anker J, Allegaert K, Dallmann A, Ahmadzia HK. Anatomical and physiological alterations of pregnancy. J Pharmacokinet Pharmacodyn. 2020;47(4):271-285. [DOI: 10.1007/s10928-020-09677-1] [PMID] [PMCID]
[4] Visser WE, Peeters RP. Interpretation of thyroid function tests during pregnancy. Best Pract Res Clin Endocrinol Metab. 2020;34(4):101431. [DOI: 10.1016/j.beem.2020.101431] [PMID]
[5] Dong AC, Stagnaro-Green A. Differences in diagnostic criteria mask the true prevalence of thyroid disease in pregnancy: a systematic review and meta-analysis. Thyroid. 2019;29(2):278-289. [DOI: 10.1089/thy.2018.0475] [PMID]
[6] Alexander EK, Pearce EN, Brent GA, Brown RS, Chen H, Dosiou C, et al. 2017 Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and the postpartum. Thyroid. 2017;27(3):315-389. [DOI: 10.1089/thy.2016.0457] [PMID]
[7] Moog NK, Entringer S, Heim C, Wadhwa PD, Kathmann N, Buss C. Influence of maternal thyroid hormones during gestation on fetal brain development. Neuroscience. 2017;342:68-100. [DOI: 10.1016/j.neuroscience.2015.09.070] [PMID] [PMCID]
[8] De Groot L, Abalovich M, Alexander EK, Amino N, Barbour L, Cobin RH, et al. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2012;97(8):2543-65. [DOI: 10.1210/jc.2011-2803] [PMID]
[9] Lagadec N, Steinecker M, Kapassi A, Magnier AM, Chastang J, Robert S, et al. Factors influencing the quality of life of pregnant women: a systematic review. BMC Pregnancy Childbirth. 2018;18(1):455. [DOI: 10.1186/s12884-018-2087-4] [PMID] [PMCID]
[10] Branco M, Santos-Rocha R, Vieira F. Biomechanics of gait during pregnancy. Scientific World Journal. 2014;2014:527940. [DOI: 10.1155/2014/527940] [PMID] [PMCID]
[11] Abbaszadeh F, Baghery A, Mehran N. [Quality of life among pregnant women (persian)]. Hayat. 2009;15(1).:41-48. [Link]
[12] Mazúchová L, Kelčíková S, Dubovická Z. Measuring women's quality of life during pregnancy. Kontakt. 2018;20(1):e31-e6. [DOI: 10.1016/j.kontakt.2017.11.004]
[13] Gadelha IP, Aquino PdS, Balsells MMD, Diniz FF, Pinheiro AKB, Ribeiro SG, et al. Quality of life of high risk pregnant women during prenatal care. Rev Bras Enferm. 2020;73(5):e20190595. [DOI: 10.1590/0034-7167-2019-0595] [PMID]
[14] Boutib A, Chergaoui S, Marfak A, Hilali A, Youlyouz-Marfak I. Quality of Life During Pregnancy from 2011 to 2021: Systematic Review. Int J Womens Health. 2022;14:975-1005. [DOI: 10.2147/IJWH. S361643] [PMID] [PMCID]
[15] Sinclair I, St-Pierre M, Elgbeili G, Bernard P, Vaillancourt C, Gagnon S, et al. Psychosocial stress, sedentary behavior, and physical activity during pregnancy among canadian women: Relationships in a diverse cohort and a nationwide sample. Int J Environ Res Public Health. 2019;16(24):5150. [DOI: 10.3390/ijerph16245150] [PMID] [PMCID]
[16] Ortega FB, Ruiz JR, Castillo MJ, Sjöström M. Physical fitness in childhood and adolescence: a powerful marker of health. Int J Obes (Lond). 2008;32(1):1-11. [DOI: 10.1038/sj.ijo.0803774] [PMID]
[17] Rodriguez-Ayllon M, Acosta-Manzano P, Coll-Risco I, Romero-Gallardo L, Borges-Cosic M, Estévez-López F, et al. Associations of physical activity, sedentary time, and physical fitness with mental health during pregnancy: The GESTAFIT project. J Sport Health Sci. 2021;10(3):379-386. [DOI: 10.1016/j.jshs.2019.04. 003] [PMID] [PMCID]
[18] Gjestland K, Bø K, Owe KM, Eberhard-Gran M. Do pregnant women follow exercise guidelines? Prevalence data among 3482 women, and prediction of low-back pain, pelvic girdle pain and depression. Br J Sports Med. 2013;47(8):515-20. [DOI: 10.1136/bjsports-2012-091344] [PMID]
[19] Weir Z, Bush J, Robson SC, McParlin C, Rankin J, Bell R. Physical activity in pregnancy :a qualitative study of the beliefs of overweight and obese pregnant women. BMC Pregnancy Childbirth. 2010;10:18. [DOI: 10.1186/1471-2393-10-18] [PMID] [PMCID]
[20] Borodulin K, Evenson KR, Wen F, Herring AH, Benson A. Physical activity patterns during pregnancy. Med Sci Sports Exerc. 2008;40(11):1901-8. [DOI: 10.1249/MSS.0b013e3181 7f1957] [PMID] [PMCID]
[21] Yamada Y, Ebara T, Matsuki T, Kano H, Tamada H, Kato S, et al. Relationship between physical activity and physical and mental health status in pregnant women: a prospective cohort study of the Japan Environment and Children’s Study. Int J Environ Res Public Health. 2021;18(21):11373. [DOI: 10.3390/ijerph18 2111373] [PMID]
[22] Suliga E, Sobaś K, Król G. Validation of the Pregnancy Physical Activity Questionnaire (PPAQ). Medical Studies. 2017;33(1): 40-5. [DOI: 10.5114/ms.2017.66955]
[23] Ghaffari G, Shirali E. [Assessing the quality of life of the people of Tehran based on the standard questionnaire of the World Health Organization WHOQOL-BREF (persian)]. Journal of Economic & Developmental Sociology. 2018;7(1):125-50. [Link]
[24] Mbada CE, Adesunkanmi HA, Orji OE, Olakorede D, Adeyemi AB, Afolabi EK, et al. Physical Activity and Health-Related Quality of Life in Pregnant Women. Women’s Health Bulletin. 2019;6(3):1-9. [DOI: doi: 10.5812/whb.90477]
[25] Lawan A, Awotidebe AW, Oyeyemi AL, Rufa AA, Oyeyemi AY. Relationship between physical activity and health related quality of life among pregnant women. Afr J Reprod Health. 2018;22(3):80-89. [DOI: 10.29063/ajrh2018/v22i3.9] [PMID]
[26] Petrov Fieril K, Fagevik Olsén M, Glantz A, Larsson M. Experiences of exercise during pregnancy among women who perform regular resistance training: a qualitative study. Afr J Reprod Health. 2018;22(3):80-89. [DOI: 10.29063/ajrh2018/ v22i3.9] [PMID]
[27] Dana A, Fallah Z, Moradi J, Ghalavand A. [The Effect of Cognitive and Aerobic Training on Cognitive and Motor Function, and Brain-Derived Neurotrophic Factors in Elderly Men (persian)]. Journal of Development and Motor Learning.
236
Rashidian S, et al. Comparison of Quality of life in Active and Inactive Pregnant Women. JSMJ. 2023; 22(2): 225-236
Jundishapur
Journal of Medical Sciences
May & June 2023. Vol 22. No 2
2019;10(4):537-52. [DOI: 10.22059/jmlm.2018.252689.1352]
[28] DSOUZA J, CHAKRABORTY A, VEIGAS J. Biological Connection to the Feeling of Happiness. Journal of Clinical & Diagnostic Research. 2020;14(10). [DOI: 10.7860/JCDR/2020/45423.14092]
[29] Hopkins SA, Baldi JC, Cutfield WS, McCowan L, Hofman PL. Exercise training in pregnancy reduces offspring size without changes in maternal insulin sensitivity. J Clin Endocrinol Metab. 2010;95(5):2080-8. [DOI: 10.1210/jc.2009-2255] [PMID]
[30] Callaway LK, Colditz PB, Byrne NM, Lingwood BE, Rowlands IJ, Foxcroft K, et al. Prevention of gestational diabetes: feasibility issues for an exercise intervention in obese pregnant women. Diabetes Care. 2010;33(7):1457-9. [DOI: 10.2337/dc09-2336] [PMID] [PMCID]
[31] Colberg SR, Castorino K, Jovanovič L. Prescribing physical activity to prevent and manage gestational diabetes. World J Diabetes. 2013;4(6):256-62. [DOI: 10.4239/wjd.v4.i6.256] [PMID]
[32] Stuebe AM, Oken E, Gillman MW. Associations of diet and physical activity during pregnancy with risk for excessive gestational weight gain. Am J Obstet Gynecol. 2009; 201(1):58.e1-8. [DOI: 10.1016/j.ajog.2009.02.025] [PMID] [PMCID]
[33] Ghalavand A, Rahmani-Ghobadi M. [Effect of Exercise and Insulin Signaling on Glucose Transporter Type 4 in Skeletal Muscles: A narrative review (persian)]. J Shahid Sadoughi Uni Med Sci. 2023;31(1):6244-57. [Link]
[34] Dipla K, Zafeiridis A, Mintziori G ,Boutou AK, Goulis DG, Hackney AC. Exercise as a therapeutic intervention in gestational diabetes mellitus. Endocrines. 2021;2(2):65-78. [DOI: 10.3390/endocrines2020007] [PMID] [PMCID]
[35] Barbour LA, McCurdy CE, Hernandez TL, Kirwan JP, Catalano PM, Friedman JE. Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes. Diabetes Care. 2007;30(12):S112-9. [DOI: 10.2337/dc07-s202] [PMID]
[36] Ghalavand A, Delaramnasab M, Afshounpour M, Zare A. [Effects of continuous aerobic exercise and circuit resistance training on fasting blood glucose control and plasma lipid profile in male patients with type II diabetes mellitus (persian)]. Journal of Diabetes Nursing. 2016;4(1):8-19. [Link]
[37] Abbas MAM, El Badrey SM, ElDeeb AM, Sayed AM. Effect of aerobic exercises on the thyroid hormones in treated hypothyroid pregnant women. Journal of Advanced Pharmacy Education & Research. 2019;9(4):49-53. [Link]
[38] Tanriverdi A, Ozcan Kahraman B, Ozsoy I, Bayraktar F, Ozgen Saydam B, Acar S, et al. Physical activity in women with subclinical hypothyroidism. J Endocrinol Invest. 2019 Jul;42(7):779-785. [DOI: 10.1007/s40618-018-0981-2] [PMID]
[39] Morgan JA, Corrigan F, Baune BT. Effects of physical exercise on central nervous system functions: a review of brain region specific adaptations. J Mol Psychiatr.2015;3(3). [DOI: 10.1186/ s40303-015-0010-8]
[40] Raichlen DA ,Alexander GE. Adaptive capacity: an evolutionary neuroscience model linking exercise, cognition, and brain health. Trends Neurosci. 2017;40(7):408-421. [DOI: 10.1016/j. tins.2017.05.001] [PMID]
[41] Bansal A, Kaushik A, Singh C, Sharma V, Singh H. The effect of regular physical exercise on the thyroid function of treated hypothyroid patients: An interventional study at a tertiary care center in Bastar region of India. Archives of Medicine and Health Sciences. 2015;3(2):244. [DOI: 10.4103/2321-4848.171913]
[42] Muscat G, Griggs R, Downes M, Emery J. Characterization of the thyroid hormone response element in the skeletal alpha-actin gene: negative regulation of T3 receptor binding by the retinoid X recepto. Cell Growth Differ. 1993;4(4):269-79. [PMID]
[43] Salazar P, Villaseca P, Cisternas P, Inestrosa NC. Neurodevelopmental impact of the offspring by thyroid hormone system-disrupting environmental chemicals during pregnancy. Environ Res. 2021;200:111345. [DOI: 10.1016/j. envres.2021.111345] [PMID]